AR057061A1 - Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos - Google Patents
Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentosInfo
- Publication number
- AR057061A1 AR057061A1 ARP060102420A ARP060102420A AR057061A1 AR 057061 A1 AR057061 A1 AR 057061A1 AR P060102420 A ARP060102420 A AR P060102420A AR P060102420 A ARP060102420 A AR P060102420A AR 057061 A1 AR057061 A1 AR 057061A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- alkoxycarbonyl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
La presente provee compuestos de la formula (1), compuestos derivados de espiro-bencimidazoles y su uso para preparar medicamentos. Los compuestos inhiben la secrecion de ácido gástrico, y por ende se utilizan en el tratamiento de enfermedades gastrointestinales. Reivindicacion 1: Un compuesto de la formula (1), en la cual: R1 es hidrogeno, alquilo C1-4, cicloalquilo C3-7, cicloalquilC3-7-alquiloC1-4, alcoxi C1-4, alcoxiC1-4-alquiloC1-4, alcoxicarbonilo C1-4, alquenilo C2-4, alquinilo C2- 4, fluoro-alquiloC1-4 o hidroxi-alquiloC1-4, R2 es hidrogeno, alquilo C1-4, alcoxi C1-4, cicloalquilo C3-7, cicloalquilC3-7-alquiloC1-4, hidroxi-alquiloC1-4, alcoxiC1-4-alquiloC1-4, alquenilo C2-4, alquinilo C2-4 o fluoro-alquiloC1-4, R3 es hidrogeno, halogeno, fluoro-alquilo C1-4, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, carboxilo, alcoxicarbonilo C1-4, hidroxi-alquiloC1-4, alcoxiC1-4-alquiloC1-4, alcoxiC1-4-alcoxiC1-4-alquiloC1-4, fluoro-alcoxiC1-4-alquiloC1-4 o el grupo -CO- NR31R32, donde R31 es hidrogeno, hidroxilo, alquilo C1-7, cicloalquilo C3-7, hidroxi-alquiloC1-4, alcoxiC1-4-alquiloC1-4, alquilcarbonilC1-4-alquilo C1-4, alquilcarbonilo C1-4 o alcoxicarbonilo C1-4; y R32 es hidrogeno, alquilo C1-7, hidroxi- alquiloC1-4, o alcoxiC1-4-alquilo C1-4, o donde R31 y R32 juntos, incluyendo el átomo de nitrogeno al cual ambos están unidos son un grupo pirrolidino, hidroxipirrolidino, piperidino, piperazino, azetidino, hidroxiazetidino, fluoroazetidino, aziridino, N-alquilpiperazinoC1-4 o morfolino, R4 y R5 son sustituyentes idénticos o diferentes seleccionados del grupo que consiste de hidrogeno, alquilo C1-4, hidroxi-alquiloC1-4, alcoxi C1-4, alcoxiC1-4-alquiloC1-4, hidroxi-alcoxiC1-4, alcoxiC1-4- alcoxiC1-4, alqueniloxi C2-4, alquilcarbonilC1-4, carboxilo, alcoxicarbonilo C1-4, carboxi-alquiloC1-4, alcoxicarbonilC1-4-alquiloC1-4, halogeno, hidroxilo, trifluorometilo, halo-alcoxiC1-4, nitro, amino, mono- o di-alquilaminoC1-4, alquilcarbonilamino C1-4, alcoxicarbonilamino C1-4, alcoxiC1-4-alcoxicarbonilaminoC1-4 o sulfonilo, y sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05105330 | 2005-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057061A1 true AR057061A1 (es) | 2007-11-14 |
Family
ID=35276210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102420A AR057061A1 (es) | 2005-06-16 | 2006-06-09 | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090093473A1 (es) |
| EP (1) | EP1899338A1 (es) |
| JP (1) | JP2008543808A (es) |
| KR (1) | KR20080020675A (es) |
| CN (1) | CN101193890A (es) |
| AR (1) | AR057061A1 (es) |
| AU (1) | AU2006259123A1 (es) |
| BR (1) | BRPI0612010A2 (es) |
| CA (1) | CA2627589A1 (es) |
| EA (1) | EA200702584A1 (es) |
| IL (1) | IL188011A0 (es) |
| MX (1) | MX2007015088A (es) |
| NO (1) | NO20080144L (es) |
| TW (1) | TW200720273A (es) |
| WO (1) | WO2006134111A1 (es) |
| ZA (1) | ZA200709852B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE449062T1 (de) * | 2007-02-22 | 2009-12-15 | Indena Spa | Verfahren zur herstellung von (2r,3s)-3- phenylisoserin-methylester-acetatsalz |
| WO2008151927A2 (en) * | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
| BRPI1013288A2 (pt) | 2009-07-09 | 2016-03-29 | Raqualia Pharma Inc | uso de um composto, método de composição farmacêutica para o tratamento de doenças em que a motilidade gastrointestinal anormal está envolvida, kit e embalagem comercial que compreende uma composição farmacêutica contendo o composto |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| CA2990165C (en) | 2015-02-02 | 2023-12-12 | Forma Therapeutics, Inc. | 3-aryl-4-amido-bicyclic [4,5,0]hydroxamic acids as hdac inhibitors |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| AR043063A1 (es) * | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
| US7307084B2 (en) * | 2003-04-04 | 2007-12-11 | Altana Pharma Ag | Cyclic benzimidazoles |
| US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
-
2006
- 2006-06-09 AR ARP060102420A patent/AR057061A1/es unknown
- 2006-06-13 AU AU2006259123A patent/AU2006259123A1/en not_active Abandoned
- 2006-06-13 MX MX2007015088A patent/MX2007015088A/es not_active Application Discontinuation
- 2006-06-13 WO PCT/EP2006/063163 patent/WO2006134111A1/en active Application Filing
- 2006-06-13 CN CNA2006800207829A patent/CN101193890A/zh active Pending
- 2006-06-13 US US11/921,508 patent/US20090093473A1/en not_active Abandoned
- 2006-06-13 CA CA002627589A patent/CA2627589A1/en not_active Abandoned
- 2006-06-13 EP EP06763684A patent/EP1899338A1/en not_active Withdrawn
- 2006-06-13 EA EA200702584A patent/EA200702584A1/ru unknown
- 2006-06-13 KR KR1020087000646A patent/KR20080020675A/ko not_active Application Discontinuation
- 2006-06-13 BR BRPI0612010-5A patent/BRPI0612010A2/pt not_active Application Discontinuation
- 2006-06-13 TW TW095120998A patent/TW200720273A/zh unknown
- 2006-06-13 JP JP2008516303A patent/JP2008543808A/ja active Pending
-
2007
- 2007-11-15 ZA ZA2007/09852A patent/ZA200709852B/en unknown
- 2007-12-10 IL IL188011A patent/IL188011A0/en unknown
-
2008
- 2008-01-09 NO NO20080144A patent/NO20080144L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008543808A (ja) | 2008-12-04 |
| EA200702584A1 (ru) | 2008-06-30 |
| BRPI0612010A2 (pt) | 2010-10-13 |
| ZA200709852B (en) | 2008-10-29 |
| CN101193890A (zh) | 2008-06-04 |
| NO20080144L (no) | 2008-01-14 |
| KR20080020675A (ko) | 2008-03-05 |
| US20090093473A1 (en) | 2009-04-09 |
| EP1899338A1 (en) | 2008-03-19 |
| MX2007015088A (es) | 2008-01-24 |
| WO2006134111A1 (en) | 2006-12-21 |
| CA2627589A1 (en) | 2006-12-21 |
| AU2006259123A8 (en) | 2008-04-03 |
| TW200720273A (en) | 2007-06-01 |
| AU2006259123A1 (en) | 2006-12-21 |
| IL188011A0 (en) | 2008-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |