ECSP23077322A - Derivados de fósforo como nuevos inhibidores de sos1 - Google Patents
Derivados de fósforo como nuevos inhibidores de sos1Info
- Publication number
- ECSP23077322A ECSP23077322A ECSENADI202377322A ECDI202377322A ECSP23077322A EC SP23077322 A ECSP23077322 A EC SP23077322A EC SENADI202377322 A ECSENADI202377322 A EC SENADI202377322A EC DI202377322 A ECDI202377322 A EC DI202377322A EC SP23077322 A ECSP23077322 A EC SP23077322A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- new
- phosphorus derivatives
- sos1
- preparation
- Prior art date
Links
- 101100404726 Arabidopsis thaliana NHX7 gene Proteins 0.000 title abstract 2
- 102000057028 SOS1 Human genes 0.000 title abstract 2
- 108700022176 SOS1 Proteins 0.000 title abstract 2
- 101100197320 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RPL35A gene Proteins 0.000 title abstract 2
- 101150100839 Sos1 gene Proteins 0.000 title abstract 2
- 150000003017 phosphorus Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención abarca los derivados de fósforo de la fórmula general (I): [IMAGEN ADJUNTA], en donde R1, R2, R3, R4, R5, R6, X1, X2, X3, X4 e Y son como se definen en el presente documento, métodos de preparación de dichos compuestos, compuestos intermedios útiles para la preparación de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento o profilaxis de enfermedades, en particular de trastornos hiperproliferativos, especialmente enfermedades asociadas a SOS1, como agente único o en combinación con otros ingredientes activos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21168256.2A EP4074317A1 (en) | 2021-04-14 | 2021-04-14 | Phosphorus derivatives as novel sos1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP23077322A true ECSP23077322A (es) | 2023-11-30 |
Family
ID=75529812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202377322A ECSP23077322A (es) | 2021-04-14 | 2023-10-12 | Derivados de fósforo como nuevos inhibidores de sos1 |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP4074317A1 (es) |
| JP (1) | JP2024513595A (es) |
| KR (1) | KR20230170032A (es) |
| CN (1) | CN117500507A (es) |
| AR (1) | AR125672A1 (es) |
| AU (1) | AU2022258751A1 (es) |
| BR (1) | BR112023019030A2 (es) |
| CA (1) | CA3216503A1 (es) |
| CL (1) | CL2023003045A1 (es) |
| CO (1) | CO2023013469A2 (es) |
| CR (1) | CR20230485A (es) |
| DO (1) | DOP2023000218A (es) |
| EC (1) | ECSP23077322A (es) |
| IL (1) | IL307448A (es) |
| MX (1) | MX2023012187A (es) |
| PE (1) | PE20240022A1 (es) |
| TW (1) | TW202304467A (es) |
| WO (1) | WO2022219035A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL298050A (en) * | 2020-05-09 | 2023-01-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Phosphorus containing sos1 inhibitor |
| CN116425796A (zh) * | 2022-01-12 | 2023-07-14 | 如东凌达生物医药科技有限公司 | 一类嘧啶并杂环类化合物、制备方法和用途 |
| WO2024056782A1 (en) * | 2022-09-16 | 2024-03-21 | Bayer Aktiengesellschaft | Sulfone-substituted pyrido[3,4-d]pyrimidine derivatives for the treatment of cancer |
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| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
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| IL298050A (en) | 2020-05-09 | 2023-01-01 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Phosphorus containing sos1 inhibitor |
-
2021
- 2021-04-14 EP EP21168256.2A patent/EP4074317A1/en not_active Ceased
-
2022
- 2022-04-13 BR BR112023019030A patent/BR112023019030A2/pt unknown
- 2022-04-13 CA CA3216503A patent/CA3216503A1/en active Pending
- 2022-04-13 JP JP2023563038A patent/JP2024513595A/ja active Pending
- 2022-04-13 MX MX2023012187A patent/MX2023012187A/es unknown
- 2022-04-13 AU AU2022258751A patent/AU2022258751A1/en active Pending
- 2022-04-13 KR KR1020237038673A patent/KR20230170032A/ko unknown
- 2022-04-13 EP EP22722729.5A patent/EP4322962A1/en active Pending
- 2022-04-13 CN CN202280041248.5A patent/CN117500507A/zh active Pending
- 2022-04-13 WO PCT/EP2022/059857 patent/WO2022219035A1/en active Application Filing
- 2022-04-13 PE PE2023002853A patent/PE20240022A1/es unknown
- 2022-04-13 CR CR20230485A patent/CR20230485A/es unknown
- 2022-04-13 AR ARP220100954A patent/AR125672A1/es unknown
- 2022-04-13 IL IL307448A patent/IL307448A/en unknown
- 2022-04-14 TW TW111114329A patent/TW202304467A/zh unknown
-
2023
- 2023-10-09 DO DO2023000218A patent/DOP2023000218A/es unknown
- 2023-10-11 CO CONC2023/0013469A patent/CO2023013469A2/es unknown
- 2023-10-12 CL CL2023003045A patent/CL2023003045A1/es unknown
- 2023-10-12 EC ECSENADI202377322A patent/ECSP23077322A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4322962A1 (en) | 2024-02-21 |
| CL2023003045A1 (es) | 2024-03-22 |
| DOP2023000218A (es) | 2023-11-15 |
| WO2022219035A1 (en) | 2022-10-20 |
| IL307448A (en) | 2023-12-01 |
| EP4074317A1 (en) | 2022-10-19 |
| AR125672A1 (es) | 2023-08-02 |
| CN117500507A (zh) | 2024-02-02 |
| TW202304467A (zh) | 2023-02-01 |
| AU2022258751A1 (en) | 2023-10-05 |
| KR20230170032A (ko) | 2023-12-18 |
| CR20230485A (es) | 2023-12-12 |
| BR112023019030A2 (pt) | 2023-10-24 |
| PE20240022A1 (es) | 2024-01-04 |
| JP2024513595A (ja) | 2024-03-26 |
| MX2023012187A (es) | 2023-10-25 |
| CA3216503A1 (en) | 2022-10-20 |
| CO2023013469A2 (es) | 2024-04-29 |
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