DOP2018000226A - Nuevos derivados de pirazolopirimidina - Google Patents

Nuevos derivados de pirazolopirimidina

Info

Publication number
DOP2018000226A
DOP2018000226A DO2018000226A DO2018000226A DOP2018000226A DO P2018000226 A DOP2018000226 A DO P2018000226A DO 2018000226 A DO2018000226 A DO 2018000226A DO 2018000226 A DO2018000226 A DO 2018000226A DO P2018000226 A DOP2018000226 A DO P2018000226A
Authority
DO
Dominican Republic
Prior art keywords
compounds
pirazolopirimidina
new derivatives
preparing
pharmaceutical compositions
Prior art date
Application number
DO2018000226A
Other languages
English (en)
Inventor
Raming Klaus
Adamczewski Martin
Hübsch Walter
Köbberling Johannes
Schwarz Hans-Georg
Görgens Ulrich
Börngen Kirsten
Ilg Thomas
Welz Claudia
Kulke Daniel
Ebbinghaus-Kintscher Ulrich
Hink Maike
Nennstiel Dirk
Köhler Adeline
Böhm Claudia
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of DOP2018000226A publication Critical patent/DOP2018000226A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

Abstract

La presente invención abarca compuestos pirazolopirimidina de fórmula general (I): (I), en donde n, o, X, Y, R, Q, R1, R2, R3 y R4 son como se definen en la presente, métodos para preparar dichos compuestos, compuestos intermediarios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento, control y/o prevención de enfermedades, en particular de infecciones helmínticas, como agente único o en combinación con otros ingredientes activos.
DO2018000226A 2016-04-15 2018-10-12 Nuevos derivados de pirazolopirimidina DOP2018000226A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16165572 2016-04-15

Publications (1)

Publication Number Publication Date
DOP2018000226A true DOP2018000226A (es) 2018-11-15

Family

ID=55755480

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2018000226A DOP2018000226A (es) 2016-04-15 2018-10-12 Nuevos derivados de pirazolopirimidina

Country Status (21)

Country Link
US (3) US10604525B2 (es)
EP (1) EP3442974B8 (es)
JP (1) JP7051703B2 (es)
KR (1) KR102467347B1 (es)
CN (1) CN109071545B (es)
AR (1) AR108130A1 (es)
AU (1) AU2017251155B2 (es)
CA (1) CA3020793A1 (es)
CL (1) CL2018002920A1 (es)
CO (1) CO2018010966A2 (es)
DO (1) DOP2018000226A (es)
ES (1) ES2953467T3 (es)
IL (1) IL261885A (es)
MX (1) MX2018012544A (es)
PH (1) PH12018550173A1 (es)
PL (1) PL3442974T3 (es)
RU (1) RU2769448C2 (es)
SG (1) SG11201808214TA (es)
TW (1) TWI742067B (es)
UY (1) UY37201A (es)
WO (1) WO2017178416A1 (es)

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Also Published As

Publication number Publication date
PH12018550173A1 (en) 2019-07-15
CN109071545A (zh) 2018-12-21
RU2018140092A3 (es) 2020-06-25
CA3020793A1 (en) 2017-10-19
RU2769448C2 (ru) 2022-03-31
US20200299299A1 (en) 2020-09-24
UY37201A (es) 2017-11-30
AU2017251155B2 (en) 2021-08-05
JP2019513776A (ja) 2019-05-30
WO2017178416A1 (en) 2017-10-19
US20190071447A1 (en) 2019-03-07
KR102467347B1 (ko) 2022-11-14
CL2018002920A1 (es) 2019-02-01
EP3442974B1 (en) 2023-06-07
EP3442974B8 (en) 2023-07-12
MX2018012544A (es) 2019-01-31
RU2018140092A (ru) 2020-05-15
ES2953467T3 (es) 2023-11-13
AU2017251155A1 (en) 2018-10-11
EP3442974C0 (en) 2023-06-07
US20200239482A1 (en) 2020-07-30
CO2018010966A2 (es) 2018-10-22
KR20180134966A (ko) 2018-12-19
PL3442974T3 (pl) 2023-12-04
IL261885A (en) 2018-10-31
JP7051703B2 (ja) 2022-04-11
EP3442974A1 (en) 2019-02-20
CN109071545B (zh) 2021-08-03
US11001590B2 (en) 2021-05-11
TWI742067B (zh) 2021-10-11
US10934301B2 (en) 2021-03-02
US10604525B2 (en) 2020-03-31
TW201803874A (zh) 2018-02-01
AR108130A1 (es) 2018-07-18
SG11201808214TA (en) 2018-10-30

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