CR8569A - Inhibidores de integrasa de vih - Google Patents

Inhibidores de integrasa de vih

Info

Publication number
CR8569A
CR8569A CR8569A CR8569A CR8569A CR 8569 A CR8569 A CR 8569A CR 8569 A CR8569 A CR 8569A CR 8569 A CR8569 A CR 8569A CR 8569 A CR8569 A CR 8569A
Authority
CR
Costa Rica
Prior art keywords
compounds
inhibitors
hiv
aids
prevention
Prior art date
Application number
CR8569A
Other languages
English (en)
Inventor
Han Wei
Egbertson Melissa
S Wai John
Zhuang Linghang
D Ruzek Rowena
S Perlow Debra
E Obligado Vanessa
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CR8569A publication Critical patent/CR8569A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de hidroxi (tetra-o-hexa-) hidronaftiridindiona de la formula I inhibidores de la integrasa de VIH e inhibidores de la replicacion de VIH en los que X1,X2,R4 y R5 se definen en la presente memoria. Los compuestos son utiles en la prevencion y tratamiento de la infeccion por VIH y en la prevencion, retraso en el inicio, y tratamiento de SIDA. Los compuestos se emplean contra la infeccion por VIH y SIDA como compuestos per se o en forma de sales farmaceuticamente aceptables. Los compuestos y sus sales pueden emplearse como ingredientes en composiciones farmaceuticas, opcionalmente combinados con otros antivirales, inmunoduladores, antibioticos o vacunas.
CR8569A 2004-03-09 2006-08-24 Inhibidores de integrasa de vih CR8569A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55162504P 2004-03-09 2004-03-09
US63313404P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
CR8569A true CR8569A (es) 2007-08-28

Family

ID=34962221

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8569A CR8569A (es) 2004-03-09 2006-08-24 Inhibidores de integrasa de vih

Country Status (15)

Country Link
US (1) US7598264B2 (es)
EP (1) EP1725556A1 (es)
JP (1) JP4625838B2 (es)
KR (1) KR20070026414A (es)
CN (1) CN1930160B (es)
AU (1) AU2005222391B2 (es)
CA (1) CA2558026C (es)
CR (1) CR8569A (es)
EA (1) EA200601654A1 (es)
EC (1) ECSP066826A (es)
IL (1) IL177858A0 (es)
MA (1) MA28519B1 (es)
NO (1) NO20064555L (es)
NZ (1) NZ549449A (es)
WO (2) WO2005087768A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7820680B2 (en) * 2004-03-09 2010-10-26 Merck & Co., Inc. HIV integrase inhibitors
US7619086B2 (en) 2004-03-09 2009-11-17 Merck & Co., Inc. HIV integrase inhibitors
CN1930161A (zh) * 2004-03-09 2007-03-14 P·安杰莱蒂分子生物学研究所 Hiv整合酶抑制剂
TWI335816B (en) 2004-05-26 2011-01-11 Eisai R&D Man Co Ltd Cinnamide compound
ATE458729T1 (de) 2004-10-26 2010-03-15 Eisai R&D Man Co Ltd Amorphe form einer zimtsäureamidverbindung
WO2006066414A1 (en) * 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
US7741315B2 (en) * 2005-05-10 2010-06-22 Merck Sharp & Dohme Corp. HIV integrase inhibitors
WO2007034812A1 (ja) 2005-09-20 2007-03-29 National University Corporation, Tokyo University Of Agriculture And Technology 分離用担体、化合物の分離方法、及びこれを用いたペプチド合成方法
US7939537B2 (en) * 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors
AU2006306355A1 (en) * 2005-10-27 2007-05-03 Merck & Co., Inc. HIV integrase inhibitors
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
EP1937643B1 (en) 2006-03-16 2016-07-13 Second Genome, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
AU2007313293A1 (en) * 2006-10-18 2008-04-24 Merck & Co., Inc. HIV integrase inhibitors
PE20081791A1 (es) 2007-02-28 2009-02-07 Eisai Randd Man Co Ltd Dos derivados ciclicos de oxomorfolina
US7687509B2 (en) 2007-07-09 2010-03-30 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
US9453000B2 (en) 2007-08-31 2016-09-27 Eisai R&D Management Co., Ltd. Polycyclic compound
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
US9107922B2 (en) 2010-07-16 2015-08-18 Concert Pharmaceuticals, Inc. Pyrimidinecarboxamide derivatives
EP2670750B1 (en) * 2011-02-02 2016-09-14 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
EP2877469A4 (en) * 2012-07-25 2016-04-06 Merck Sharp & Dohme SUBSTITUTED NAPHTHYRIDINEDIONE DERIVATIVES AS INHIBITORS OF HIV INTEGRASE
ME02977B (me) * 2013-05-17 2018-10-20 Merck Sharp & Dohme Fuzionisana triciklicna heterociklicna jedinjenja као inhibiтori hiv integraze
WO2015048363A1 (en) 2013-09-27 2015-04-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
US10081647B2 (en) 2015-03-26 2018-09-25 Merck Sharp & Dohme Corp. Phosphate substituted quinolizine derivatives useful as HIV integrase inhibitors
US11642315B2 (en) * 2017-10-02 2023-05-09 Novartis Ag Method for preparing a pharmaceutical product
IL312009A (en) * 2021-10-08 2024-06-01 Vrise Therapeutics Inc Small molecules for cancer treatment
WO2023105491A1 (en) * 2021-12-10 2023-06-15 Vrise Therapeutics, Inc. 5,6,7,8-tetrahydro-2,6-naphthyridine derivatives as cancer therapeutics

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
AU5880600A (en) 1999-06-25 2001-01-31 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
WO2002036734A2 (en) 2000-10-12 2002-05-10 Merck & Co., Inc. Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors
AU1532802A (en) 2000-10-12 2002-04-22 Merck & Co Inc Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
ATE430745T1 (de) 2000-10-12 2009-05-15 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
US6841558B2 (en) 2000-10-12 2005-01-11 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
KR20030078958A (ko) * 2001-03-01 2003-10-08 시오노기세이야쿠가부시키가이샤 Ｈｉｖ 인테그라제 저해 활성을 갖는 질소 함유의헤테로아릴 화합물
ES2587564T1 (es) 2001-08-10 2016-10-25 Shionogi & Co., Ltd. Agente antiviral
IL161337A0 (en) 2001-10-26 2004-09-27 Angeletti P Ist Richerche Bio N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
DK1441734T3 (da) 2001-10-26 2007-06-11 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carboxamid-inhibitorer a HIV-integrase
AU2003216049B2 (en) 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
WO2003077857A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2004004657A2 (en) 2002-07-09 2004-01-15 Bristol-Myers Squibb Company Hiv integrase inhibitors
MXPA05001786A (es) * 2002-08-13 2005-04-25 Warner Lambert Co Derivados de azaisoquinolina como inhibidores de la metaloproteinasa de matriz.
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
JP2006232849A (ja) * 2003-08-13 2006-09-07 Japan Tobacco Inc 含窒素縮合環化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
US7619086B2 (en) 2004-03-09 2009-11-17 Merck & Co., Inc. HIV integrase inhibitors
US7820680B2 (en) 2004-03-09 2010-10-26 Merck & Co., Inc. HIV integrase inhibitors
CN1930161A (zh) 2004-03-09 2007-03-14 P·安杰莱蒂分子生物学研究所 Hiv整合酶抑制剂
US7741315B2 (en) 2005-05-10 2010-06-22 Merck Sharp & Dohme Corp. HIV integrase inhibitors

Also Published As

Publication number Publication date
JP2007528401A (ja) 2007-10-11
MA28519B1 (fr) 2007-04-03
NO20064555L (no) 2006-12-04
AU2005222391A1 (en) 2005-09-22
KR20070026414A (ko) 2007-03-08
AU2005222391B2 (en) 2010-11-11
JP4625838B2 (ja) 2011-02-02
IL177858A0 (en) 2006-12-31
ECSP066826A (es) 2006-11-24
CA2558026C (en) 2010-12-14
US20070179196A1 (en) 2007-08-02
WO2005087768A1 (en) 2005-09-22
WO2005087767A1 (en) 2005-09-22
EP1725556A1 (en) 2006-11-29
CN1930160A (zh) 2007-03-14
EA200601654A1 (ru) 2007-02-27
CN1930160B (zh) 2011-11-16
NZ549449A (en) 2009-05-31
CA2558026A1 (en) 2005-09-22
US7598264B2 (en) 2009-10-06

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