ATE517899T1 - Hiv-integrasehemmer - Google Patents

Hiv-integrasehemmer

Info

Publication number
ATE517899T1
ATE517899T1 AT06792296T AT06792296T ATE517899T1 AT E517899 T1 ATE517899 T1 AT E517899T1 AT 06792296 T AT06792296 T AT 06792296T AT 06792296 T AT06792296 T AT 06792296T AT E517899 T1 ATE517899 T1 AT E517899T1
Authority
AT
Austria
Prior art keywords
compounds
hiv
inhibitors
hiv integrase
integrase inhibitors
Prior art date
Application number
AT06792296T
Other languages
English (en)
Inventor
Monica Donghi
Vincenzo Summa
Olaf Kinzel
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Application granted granted Critical
Publication of ATE517899T1 publication Critical patent/ATE517899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06792296T 2005-10-04 2006-09-26 Hiv-integrasehemmer ATE517899T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72356705P 2005-10-04 2005-10-04
PCT/EP2006/009410 WO2007039218A1 (en) 2005-10-04 2006-09-26 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
ATE517899T1 true ATE517899T1 (de) 2011-08-15

Family

ID=37621988

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06792296T ATE517899T1 (de) 2005-10-04 2006-09-26 Hiv-integrasehemmer

Country Status (7)

Country Link
US (1) US7939537B2 (de)
EP (1) EP1937678B1 (de)
JP (1) JP5094725B2 (de)
AT (1) ATE517899T1 (de)
AU (1) AU2006299042B8 (de)
CA (1) CA2622639C (de)
WO (1) WO2007039218A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101880280B (zh) * 2006-12-22 2014-07-16 中国科学院上海有机化学研究所 双环嘧啶酮以及其应用
CA2677493A1 (en) * 2007-02-05 2008-08-14 Xenon Pharmaceuticals Inc. Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions
RU2503679C2 (ru) 2007-11-15 2014-01-10 Джилид Сайенсиз, Инк. Ингибиторы репликации вируса иммунодефицита человека
DK2220076T5 (da) 2007-11-15 2012-09-17 Gilead Sciences Inc Inhibitorer af replikationen af humant immundefektvirus
EA201200631A1 (ru) 2007-11-16 2012-11-30 Джилид Сайенсиз, Инк. Ингибиторы репликации вируса иммунодефицита человека
JP5535204B2 (ja) * 2008-07-02 2014-07-02 アベキサ・リミテッド 抗ウイルス特性を有する化合物
CN102336751A (zh) * 2010-07-16 2012-02-01 爱维艾珂瑟有限公司 新型抗病毒剂
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
CA3162166A1 (en) 2019-12-02 2021-06-10 Storm Therapeutics Limited Polyheterocyclic compounds as mettl3 inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CZ20031028A3 (cs) 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
US20050010048A1 (en) 2000-10-12 2005-01-13 Linghang Zhuang Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors
WO2002030426A1 (en) 2000-10-12 2002-04-18 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
ES2274913T3 (es) 2000-10-12 2007-06-01 MERCK & CO., INC. Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de vih integrada.
CN1659143A (zh) * 2001-03-01 2005-08-24 盐野义制药株式会社 具有hiv整合酶抑制活性的含氮杂芳基化合物
CN101513402B (zh) * 2001-08-10 2012-03-21 盐野义制药株式会社 抗病毒药
DE60218511T2 (de) 2001-10-26 2007-10-25 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
BRPI0213522C1 (pt) 2001-10-26 2021-05-25 St Di Ricerche Di Biologia Molecolare P Angeletti S P A compostos derivados de hidroxipirimidinona, composição farmacêutica, e, uso de um composto
JP4170633B2 (ja) * 2001-11-12 2008-10-22 独立行政法人科学技術振興機構 拡張型心筋症の原因となる新規点突然変異を有するデスミン遺伝子
JP4523281B2 (ja) 2002-01-17 2010-08-11 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
GB0201179D0 (en) 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
US7109186B2 (en) 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
EP1578748B1 (de) 2002-12-27 2010-09-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Tetrahydro-4h-pyrido[1,2-a]pyrimidine und verwandte verbindungen verwendbar als hiv integrase hemmer
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200526635A (en) * 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
CN101014574A (zh) 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
EP1725556A1 (de) 2004-03-09 2006-11-29 Merck & Co., Inc. Hiv-integrasehemmer
WO2005087766A1 (en) 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
US7176196B2 (en) * 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7192948B2 (en) * 2004-05-28 2007-03-20 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
WO2006116764A1 (en) 2005-04-28 2006-11-02 Smithkline Beecham Corporation Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity

Also Published As

Publication number Publication date
EP1937678A1 (de) 2008-07-02
US20090221571A1 (en) 2009-09-03
AU2006299042A1 (en) 2007-04-12
JP2009510148A (ja) 2009-03-12
AU2006299042B8 (en) 2011-09-15
WO2007039218A1 (en) 2007-04-12
EP1937678B1 (de) 2011-07-27
CA2622639C (en) 2012-01-03
US7939537B2 (en) 2011-05-10
JP5094725B2 (ja) 2012-12-12
CA2622639A1 (en) 2007-04-12
AU2006299042B2 (en) 2011-09-01
AU2006299042A8 (en) 2011-09-15

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Legal Events

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