TW200640460A - HIV integrase inhibitors - Google Patents

HIV integrase inhibitors

Info

Publication number
TW200640460A
TW200640460A TW094116543A TW94116543A TW200640460A TW 200640460 A TW200640460 A TW 200640460A TW 094116543 A TW094116543 A TW 094116543A TW 94116543 A TW94116543 A TW 94116543A TW 200640460 A TW200640460 A TW 200640460A
Authority
TW
Taiwan
Prior art keywords
compounds
hiv
inhibitors
hiv integrase
aids
Prior art date
Application number
TW094116543A
Other languages
Chinese (zh)
Inventor
John S Wai
Joseph P Vacca
Ling-Hang Zhuang
Bo-Young Kim
Terry A Lyle
Catherine M Wiscount
Melissa S Egbertson
Lou Anne Neilson
Mark Embrey
Thorsten E Fisher
Donnette D Staas
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of TW200640460A publication Critical patent/TW200640460A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Hydroxy-substituted pyrazinopyrrolopyndazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula I: , wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
TW094116543A 2004-05-07 2005-05-20 HIV integrase inhibitors TW200640460A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59615004P 2004-05-07 2004-05-07

Publications (1)

Publication Number Publication Date
TW200640460A true TW200640460A (en) 2006-12-01

Family

ID=57809881

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094116543A TW200640460A (en) 2004-05-07 2005-05-20 HIV integrase inhibitors

Country Status (1)

Country Link
TW (1) TW200640460A (en)

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