BR0313724A - Derivados de azaisoquinolina como inibidores de metaloproteinase de matriz - Google Patents
Derivados de azaisoquinolina como inibidores de metaloproteinase de matrizInfo
- Publication number
- BR0313724A BR0313724A BR0313724-4A BR0313724A BR0313724A BR 0313724 A BR0313724 A BR 0313724A BR 0313724 A BR0313724 A BR 0313724A BR 0313724 A BR0313724 A BR 0313724A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- formula
- acceptable salt
- relates
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE AZAISOQUINOLINA COMO INIBIDORES DE METALOPROTEINASE DE MATRIZ". A presente invenção refere-se a compostos definidos pela Fórmula I ou um seu sal farmaceuticamente aceitável, em que R^ 1^ , Q, Y, R^ 2^, R^ 3^, R^ 4^, R^ 5^ e n são como definido no relatório descritivo. A invenção também refere-se a composições farmacêuticas compreendendo um composto de Fórmula I, ou um seu sal farmaceuticamente aceitável, como definido no relatório descritivo, juntamente com um veículo, diluente ou excipiente farmaceuticamente aceitável. A invenção também refere-se a métodos de inibição de uma enzima MMP-13 em um animal, compreendendo a administração ao animal de um composto de Fórmula I, ou de um seu sal farmaceuticamente aceitável. A invenção também refere-se a métodos de tratamento de uma doença mediada por uma enzima MMP-13 em um animal, compreendendo a administração ao animal de um composto de Fórmula I, ou de um seu sal farmaceuticamente aceitável, quer sozinho ou em uma composição farmacêutica. A invenção também refere-se a métodos de tratamento de doenças tais como doença cardíaca, esclerose múltipla, osteoartrite e artrite reumatóide, outras artrites para além de osteoartrite ou artrite reumatóide, insuficiência cardíaca, doença inflamatória do intestino, insuficiência cardíaca, degeneração macular relacionada com a idade, doença pulmonar obstrutiva crónica, asma, doenças periodontais, psoríase, aterosclerose e osteoporose em um paciente, compreendendo a administração ao paciente de um composto de Fórmula I, ou de um seu sal farmaceuticamente aceitável, quer sozinho ou em uma composição farmacêutica. A invenção também refere-se a combinações, compreendendo um composto de Fórmula I, ou um seu sal farmaceuticamente aceitável, juntamente com ou componente ativo farmaceuticamente como descrito no relatório descritivo. Novo quadro reivindicatório (total de 8 reivindicações), incorporando as emendas às reivindicações, conforme relatório de exame preliminar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40321902P | 2002-08-13 | 2002-08-13 | |
PCT/IB2003/003485 WO2004014866A1 (en) | 2002-08-13 | 2003-08-04 | Azaisoquinoline derivatives as matrix metalloproteinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313724A true BR0313724A (pt) | 2005-06-28 |
Family
ID=31715962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313724-4A BR0313724A (pt) | 2002-08-13 | 2003-08-04 | Derivados de azaisoquinolina como inibidores de metaloproteinase de matriz |
Country Status (8)
Country | Link |
---|---|
US (1) | US6977261B2 (pt) |
EP (1) | EP1539709A1 (pt) |
JP (1) | JP2006504665A (pt) |
AU (1) | AU2003249531A1 (pt) |
BR (1) | BR0313724A (pt) |
CA (1) | CA2495293A1 (pt) |
MX (1) | MXPA05001786A (pt) |
WO (1) | WO2004014866A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6894057B2 (en) | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
PA8578101A1 (es) * | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
US20040142950A1 (en) * | 2003-01-17 | 2004-07-22 | Bunker Amy Mae | Amide and ester matrix metalloproteinase inhibitors |
WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
US20060247231A1 (en) * | 2003-12-18 | 2006-11-02 | Warner-Lambert Company Llc | Amide and ester matrix metalloproteinase inhibitors |
WO2005087768A1 (en) * | 2004-03-09 | 2005-09-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
CN101119969B (zh) | 2004-07-15 | 2014-04-09 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用 |
CN101595109B (zh) * | 2006-11-20 | 2012-09-05 | 百时美施贵宝公司 | 作为二肽基肽酶ⅳ抑制剂的7,8-二氢-1,6-二氮杂萘-5(6h)-酮和相关二环化合物及方法 |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
TWI405565B (zh) * | 2009-04-01 | 2013-08-21 | Colgate Palmolive Co | 口腔用組成物之抗-骨質流失及抗-牙周附連喪失之功效 |
ES2662072T3 (es) * | 2009-05-12 | 2018-04-05 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma |
ES2446971T3 (es) * | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
ES2528404T3 (es) * | 2009-05-12 | 2015-02-10 | Bristol-Myers Squibb Company | Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos |
WO2012052451A1 (en) | 2010-10-18 | 2012-04-26 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
NZ617987A (en) | 2011-05-10 | 2016-02-26 | Gilead Sciences Inc | Fused heterocyclic compounds as sodium channel modulators |
NO3175985T3 (pt) | 2011-07-01 | 2018-04-28 | ||
TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
CA2927830A1 (en) | 2013-10-23 | 2015-04-30 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
CA3188639A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
WO2022140231A1 (en) | 2020-12-21 | 2022-06-30 | Incyte Corporation | Deazaguaine compounds as jak2 v617f inhibitors |
CA3211748A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU664912B2 (en) * | 1992-09-02 | 1995-12-07 | Dainippon Pharmaceutical Co. Ltd. | Novel 3-oxadiazolyl-1,6-naphthyridine derivatives |
ES2224130T3 (es) * | 1994-08-09 | 2005-03-01 | Eisai Co., Ltd. | Compuesto de piridazina condensada. |
US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
GB9711257D0 (en) * | 1997-05-30 | 1997-07-30 | Smithkline Beecham Plc | Novel compounds |
JPH11199512A (ja) | 1997-10-24 | 1999-07-27 | Pfizer Prod Inc | 変形性関節症および他のmmp媒介疾患の治療のためのmmp−13選択的阻害剤の使用 |
UA59453C2 (uk) | 1998-08-12 | 2003-09-15 | Пфайзер Продактс Інк. | Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ |
PA8498701A1 (es) | 1999-08-12 | 2002-08-26 | Pfizer Prod Inc | Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas |
US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
EP1138680A1 (en) | 2000-03-29 | 2001-10-04 | Pfizer Products Inc. | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors |
WO2001096607A2 (en) * | 2000-06-13 | 2001-12-20 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
MXPA03003734A (es) | 2000-10-26 | 2003-07-28 | Pfizer Prod Inc | Inhibifores de metaloproteinasa del tipo pirimidin-2, 4, 6-triona. |
EE200300196A (et) | 2000-10-26 | 2003-10-15 | Pfizer Products Inc. | Spiropürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid |
US7374882B2 (en) * | 2000-11-28 | 2008-05-20 | Riken | Method for base sequencing and biologically active nucleic acids |
PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
DOP2002000332A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Inhibidores de piridina de metaloproteinasas de la matriz |
DOP2002000328A (es) * | 2001-02-14 | 2003-08-30 | Warner Lambert Co | Pirimidinas inhibidoras de metaloproteinasas de matriz |
CA2433778A1 (en) * | 2001-02-14 | 2002-08-22 | William Glen Harter | Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors |
PA8539301A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Inhibidores de la metaloproteinasa de la matriz |
DOP2002000334A (es) | 2001-02-14 | 2002-08-30 | Warner Lambert Co | Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz |
ATE280164T1 (de) * | 2001-02-14 | 2004-11-15 | Warner Lambert Co | Benzothiadiazine als matrix metallproteinase inhibitoren |
PA8539501A1 (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
DOP2002000333A (es) | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz |
US6924276B2 (en) * | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
US6962922B2 (en) * | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
PA8556301A1 (es) | 2001-10-12 | 2003-09-05 | Warner Lambert Co | Compuestos pirimidina de anillo fusionado alquinilado |
EP1434585A1 (en) * | 2001-10-12 | 2004-07-07 | Warner-Lambert Company LLC | Alkyne matrix metalloproteinase inhibitors |
US6894057B2 (en) * | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6747147B2 (en) * | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
AU2002249275A1 (en) | 2002-03-08 | 2003-09-22 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
AU2002333256A1 (en) | 2002-06-25 | 2004-01-06 | Warner-Lambert Company Llc | Thiazine and oxazine derivatives as mmp-13 inhibitors for treating arthritis |
-
2003
- 2003-08-04 BR BR0313724-4A patent/BR0313724A/pt not_active Application Discontinuation
- 2003-08-04 JP JP2004527200A patent/JP2006504665A/ja active Pending
- 2003-08-04 EP EP03784388A patent/EP1539709A1/en not_active Withdrawn
- 2003-08-04 WO PCT/IB2003/003485 patent/WO2004014866A1/en not_active Application Discontinuation
- 2003-08-04 CA CA002495293A patent/CA2495293A1/en not_active Abandoned
- 2003-08-04 AU AU2003249531A patent/AU2003249531A1/en not_active Abandoned
- 2003-08-04 MX MXPA05001786A patent/MXPA05001786A/es unknown
- 2003-08-05 US US10/634,289 patent/US6977261B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2006504665A (ja) | 2006-02-09 |
WO2004014866A1 (en) | 2004-02-19 |
AU2003249531A1 (en) | 2004-02-25 |
EP1539709A1 (en) | 2005-06-15 |
US6977261B2 (en) | 2005-12-20 |
MXPA05001786A (es) | 2005-04-25 |
CA2495293A1 (en) | 2004-02-19 |
US20040038961A1 (en) | 2004-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |