MA28519B1 - Inhibiteurs de l'integrase du vih - Google Patents

Inhibiteurs de l'integrase du vih

Info

Publication number
MA28519B1
MA28519B1 MA29370A MA29370A MA28519B1 MA 28519 B1 MA28519 B1 MA 28519B1 MA 29370 A MA29370 A MA 29370A MA 29370 A MA29370 A MA 29370A MA 28519 B1 MA28519 B1 MA 28519B1
Authority
MA
Morocco
Prior art keywords
inhibitors
hiv integrase
integrase
hiv
Prior art date
Application number
MA29370A
Other languages
English (en)
Inventor
Wei Han
Melissa Egbertson
John S Wai
Linghang Zhuang
Rowena D Ruzek
Debra S Perlow
Vanessa E Obligado
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA28519B1 publication Critical patent/MA28519B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA29370A 2004-03-09 2006-10-05 Inhibiteurs de l'integrase du vih MA28519B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55162504P 2004-03-09 2004-03-09
US63313404P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
MA28519B1 true MA28519B1 (fr) 2007-04-03

Family

ID=34962221

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29370A MA28519B1 (fr) 2004-03-09 2006-10-05 Inhibiteurs de l'integrase du vih

Country Status (15)

Country Link
US (1) US7598264B2 (fr)
EP (1) EP1725556A1 (fr)
JP (1) JP4625838B2 (fr)
KR (1) KR20070026414A (fr)
CN (1) CN1930160B (fr)
AU (1) AU2005222391B2 (fr)
CA (1) CA2558026C (fr)
CR (1) CR8569A (fr)
EA (1) EA200601654A1 (fr)
EC (1) ECSP066826A (fr)
IL (1) IL177858A0 (fr)
MA (1) MA28519B1 (fr)
NO (1) NO20064555L (fr)
NZ (1) NZ549449A (fr)
WO (2) WO2005087768A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
AU2005227258A1 (en) * 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
WO2005087766A1 (fr) * 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Inhibiteurs de l'intégrase du vih
CN101014574A (zh) * 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
EP2261218B1 (fr) 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Imidazolverbindung zur Verwendung als Intermediat in der Herstellung von Cinnamid-Verbindungen
ES2338904T3 (es) 2004-10-26 2010-05-13 EISAI R&D MANAGEMENT CO., LTD. Forma amorfa de compuestos de cinamida.
CA2634499A1 (fr) * 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones et procedes d'inhibition de l'integrase du vih
EP1881825B1 (fr) * 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Inhibiteurs de l'intégrase du vih
AU2006293180A1 (en) 2005-09-20 2007-03-29 Jitsubo Co., Ltd. Carrier for separation, method for separation of compound, and method for synthesis of peptide using the carrier
US7939537B2 (en) * 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors
EP1942736A2 (fr) * 2005-10-27 2008-07-16 Merck & Co., Inc. Inhibiteurs de l'integrase du vih
AU2006316005A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamamide derivative
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
CA2645551C (fr) 2006-03-16 2016-06-28 Renovis, Inc. Composes de bicycloheteroaryle en tant que modulateurs de p2x7 et leurs utilisations
EP2084160A1 (fr) * 2006-10-18 2009-08-05 Merck & Co., Inc. Inhibiteurs du vih intégrase
US20080207900A1 (en) 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
US7687509B2 (en) 2007-07-09 2010-03-30 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
EP2559693B1 (fr) 2007-08-31 2014-11-26 Eisai R&D Management Co., Ltd. Composé polycyclique
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
WO2012009446A1 (fr) 2010-07-16 2012-01-19 Concert Pharmaceuticals Inc. Nouveaux dérivés pyrimidinecarboxamide
US8921389B2 (en) * 2011-02-02 2014-12-30 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase
US9089574B2 (en) 2011-11-30 2015-07-28 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
EP2877469A4 (fr) * 2012-07-25 2016-04-06 Merck Sharp & Dohme Dérivés de naphthyridinedione substitués en tant qu'inhibiteurs de l'intégrase du vih
ME02977B (fr) 2013-05-17 2018-10-20 Merck Sharp & Dohme Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih
EA030695B1 (ru) * 2013-09-27 2018-09-28 Мерк Шарп И Доум Корп. Замещенные производные хинолизина, которые можно использовать как ингибиторы интегразы вич
EP3285582B1 (fr) * 2015-03-26 2020-11-11 Merck Sharp & Dohme Corp. Dérivés de quinolizine substitués par un phosphate utiles en tant qu'inhibiteurs de l'intégrase du vih
AU2018346826B2 (en) * 2017-10-02 2021-09-16 Novartis Ag Method for preparing a pharmaceutical product
KR20240073982A (ko) * 2021-10-08 2024-05-27 브이라이즈 테라퓨틱스, 인코퍼레이티드 암 치료를 위한 소분자
TW202342471A (zh) * 2021-12-10 2023-11-01 美商薇瑞絲生物製藥公司 作為癌症治療藥物的小分子

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
JP2003503386A (ja) 1999-06-25 2003-01-28 メルク エンド カムパニー インコーポレーテッド １−（芳香族またはヘテロ芳香族置換）−３−（ヘテロ芳香族置換）−１，３−プロパンジオン類およびそれの使用
ES2274913T3 (es) 2000-10-12 2007-06-01 MERCK & CO., INC. Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de vih integrada.
US20050010048A1 (en) 2000-10-12 2005-01-13 Linghang Zhuang Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors
CZ20031028A3 (cs) 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
WO2002030426A1 (fr) 2000-10-12 2002-04-18 Merck & Co., Inc. Azanaphthalenylcarboxamides et polyazanaphthalenylcarboxamides utiles en tant qu'inhibiteurs de la vih integrase
CN1659143A (zh) * 2001-03-01 2005-08-24 盐野义制药株式会社 具有hiv整合酶抑制活性的含氮杂芳基化合物
CN101513402B (zh) 2001-08-10 2012-03-21 盐野义制药株式会社 抗病毒药
BRPI0213522C1 (pt) 2001-10-26 2021-05-25 St Di Ricerche Di Biologia Molecolare P Angeletti S P A compostos derivados de hidroxipirimidinona, composição farmacêutica, e, uso de um composto
DE60218511T2 (de) 2001-10-26 2007-10-25 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
JP4523281B2 (ja) * 2002-01-17 2010-08-11 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
AU2003218130A1 (en) * 2002-03-15 2003-09-29 Merck And Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
US7109186B2 (en) 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2004014866A1 (fr) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Derives d'azaisoquinoline utilises comme inhibiteurs de metalloproteases matricielles
JP2006232849A (ja) * 2003-08-13 2006-09-07 Japan Tobacco Inc 含窒素縮合環化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CN101014574A (zh) 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
AU2005227258A1 (en) 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
WO2005087766A1 (fr) 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Inhibiteurs de l'intégrase du vih
EP1881825B1 (fr) 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Inhibiteurs de l'intégrase du vih

Also Published As

Publication number Publication date
ECSP066826A (es) 2006-11-24
KR20070026414A (ko) 2007-03-08
US7598264B2 (en) 2009-10-06
AU2005222391B2 (en) 2010-11-11
CR8569A (es) 2007-08-28
NZ549449A (en) 2009-05-31
EA200601654A1 (ru) 2007-02-27
CA2558026C (fr) 2010-12-14
JP4625838B2 (ja) 2011-02-02
WO2005087768A1 (fr) 2005-09-22
JP2007528401A (ja) 2007-10-11
IL177858A0 (en) 2006-12-31
EP1725556A1 (fr) 2006-11-29
WO2005087767A1 (fr) 2005-09-22
NO20064555L (no) 2006-12-04
CA2558026A1 (fr) 2005-09-22
CN1930160A (zh) 2007-03-14
CN1930160B (zh) 2011-11-16
US20070179196A1 (en) 2007-08-02
AU2005222391A1 (en) 2005-09-22

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