ITMI20041963A1 - "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche" - Google Patents

"antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"

Info

Publication number
ITMI20041963A1
ITMI20041963A1 IT001963A ITMI20041963A ITMI20041963A1 IT MI20041963 A1 ITMI20041963 A1 IT MI20041963A1 IT 001963 A IT001963 A IT 001963A IT MI20041963 A ITMI20041963 A IT MI20041963A IT MI20041963 A1 ITMI20041963 A1 IT MI20041963A1
Authority
IT
Italy
Prior art keywords
peptidial
bradichinin
antagonists
pharmaceutical compositions
pharmaceutical
Prior art date
Application number
IT001963A
Other languages
English (en)
Inventor
Patrizia Felicetti
Christopher Ingo Fincham
Alessandro Giolitti
Carlo Alberto Maggi
Laura Quartara
Cristina Rossi
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to IT001963A priority Critical patent/ITMI20041963A1/it
Publication of ITMI20041963A1 publication Critical patent/ITMI20041963A1/it
Priority to PL05789989T priority patent/PL1799214T3/pl
Priority to NZ554469A priority patent/NZ554469A/en
Priority to CN2005800348339A priority patent/CN101039671B/zh
Priority to GEAP20059985A priority patent/GEP20115322B/en
Priority to AU2005293881A priority patent/AU2005293881B2/en
Priority to MX2007004297A priority patent/MX2007004297A/es
Priority to PT05789989T priority patent/PT1799214E/pt
Priority to SI200530175T priority patent/SI1799214T1/sl
Priority to BRPI0515983-0A priority patent/BRPI0515983A/pt
Priority to CA2583920A priority patent/CA2583920C/en
Priority to ZA200703009A priority patent/ZA200703009B/xx
Priority to EP05789989A priority patent/EP1799214B8/en
Priority to JP2007536029A priority patent/JP4980917B2/ja
Priority to DK05789989T priority patent/DK1799214T3/da
Priority to AT05789989T priority patent/ATE381931T1/de
Priority to EA200700584A priority patent/EA010913B1/ru
Priority to PCT/EP2005/010412 priority patent/WO2006040004A1/en
Priority to UAA200702710A priority patent/UA86091C2/ru
Priority to DE602005004039T priority patent/DE602005004039T2/de
Priority to ES05789989T priority patent/ES2299090T3/es
Priority to RSP-2008/0110A priority patent/RS50563B/sr
Priority to ARP050104324A priority patent/AR051392A1/es
Priority to US11/786,041 priority patent/US7645759B2/en
Priority to NO20071840A priority patent/NO339805B1/no
Priority to IL182494A priority patent/IL182494A/en
Priority to MA29870A priority patent/MA29007B1/fr
Priority to HK07113112.9A priority patent/HK1107263A1/xx
Priority to HR20080107T priority patent/HRP20080107T3/xx
Priority to CY20081100314T priority patent/CY1107254T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
IT001963A 2004-10-15 2004-10-15 "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche" ITMI20041963A1 (it)

Priority Applications (30)

Application Number Priority Date Filing Date Title
IT001963A ITMI20041963A1 (it) 2004-10-15 2004-10-15 "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"
RSP-2008/0110A RS50563B (sr) 2004-10-15 2005-09-27 Ne-peptidni bradikinin antagonisti i njihove farmaceutske mešavine
DK05789989T DK1799214T3 (da) 2004-10-15 2005-09-27 Ikke-peptid-bradykinin-antagonister og famaceutiske sammensætninger heraf
EA200700584A EA010913B1 (ru) 2004-10-15 2005-09-27 Непептидные антагонисты брадикинина и фармацевтические композиции на их основе
AT05789989T ATE381931T1 (de) 2004-10-15 2005-09-27 Nicht-peptidische bradykinin-antagonisten und pharmazeutische zusammensetzungen daraus
GEAP20059985A GEP20115322B (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
NZ554469A NZ554469A (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
MX2007004297A MX2007004297A (es) 2004-10-15 2005-09-27 Antagonistas no peptidicos de bradiquinina y composiciones farmaceuticas de los mismos.
PT05789989T PT1799214E (pt) 2004-10-15 2005-09-27 Antagonistas da bradiquinina não peptídicos e composições farmacêuticas derivadas
SI200530175T SI1799214T1 (sl) 2004-10-15 2005-09-27 Nepeptidni bradikininski antagonisti in farmacevtski sestavki iz njih
BRPI0515983-0A BRPI0515983A (pt) 2004-10-15 2005-09-27 antagonistas não peptìdicos da bradicinina, composições farmacêuticas compreendendo os mesmos e uso
CA2583920A CA2583920C (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
ZA200703009A ZA200703009B (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
PCT/EP2005/010412 WO2006040004A1 (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
JP2007536029A JP4980917B2 (ja) 2004-10-15 2005-09-27 非ペプチドブラジキニンアンタゴニストおよびそれによる医薬組成物
PL05789989T PL1799214T3 (pl) 2004-10-15 2005-09-27 Niepeptydowi antagoniści bradykininy i kompozycje farmaceutyczne zawierające tych antagonistów
CN2005800348339A CN101039671B (zh) 2004-10-15 2005-09-27 非肽类缓激肽拮抗剂及其药物组合物
AU2005293881A AU2005293881B2 (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
EP05789989A EP1799214B8 (en) 2004-10-15 2005-09-27 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
UAA200702710A UA86091C2 (ru) 2004-10-15 2005-09-27 Непептидные антагонисты брадикинина и их фармацевтическая композиция
DE602005004039T DE602005004039T2 (de) 2004-10-15 2005-09-27 Nicht-peptidische bradykinin-antagonisten und pharmazeutische zusammensetzungen daraus
ES05789989T ES2299090T3 (es) 2004-10-15 2005-09-27 Antagonistas de bradiquinina no peptidicos y composiciones farmaceuticas de los mismos.
ARP050104324A AR051392A1 (es) 2004-10-15 2005-10-14 Antagonistas no peptidicos de bradiquinina y composiciones farmaceuticas de los mismos
US11/786,041 US7645759B2 (en) 2004-10-15 2007-04-10 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
NO20071840A NO339805B1 (no) 2004-10-15 2007-04-11 Ikke-peptid bradykininantagonister og farmasøytiske sammensetninger derav samt anvendelse av slike.
IL182494A IL182494A (en) 2004-10-15 2007-04-12 Non-peptide antagonists of bradykinin and pharmacological preparations containing them
MA29870A MA29007B1 (fr) 2004-10-15 2007-05-04 Antagonistes de bradykinine non-peptidiques et compositions pharmaceutiques constituees de ces composes
HK07113112.9A HK1107263A1 (en) 2004-10-15 2007-11-30 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
HR20080107T HRP20080107T3 (en) 2004-10-15 2008-03-10 Non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
CY20081100314T CY1107254T1 (el) 2004-10-15 2008-03-20 Μη πεπτιδικοι ανταγωνιστες της ωραδυκινινης και φαρμακευτικες συνθεσεις αυτων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001963A ITMI20041963A1 (it) 2004-10-15 2004-10-15 "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"

Publications (1)

Publication Number Publication Date
ITMI20041963A1 true ITMI20041963A1 (it) 2005-01-15

Family

ID=35810869

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001963A ITMI20041963A1 (it) 2004-10-15 2004-10-15 "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"

Country Status (30)

Country Link
US (1) US7645759B2 (it)
EP (1) EP1799214B8 (it)
JP (1) JP4980917B2 (it)
CN (1) CN101039671B (it)
AR (1) AR051392A1 (it)
AT (1) ATE381931T1 (it)
AU (1) AU2005293881B2 (it)
BR (1) BRPI0515983A (it)
CA (1) CA2583920C (it)
CY (1) CY1107254T1 (it)
DE (1) DE602005004039T2 (it)
DK (1) DK1799214T3 (it)
EA (1) EA010913B1 (it)
ES (1) ES2299090T3 (it)
GE (1) GEP20115322B (it)
HK (1) HK1107263A1 (it)
HR (1) HRP20080107T3 (it)
IL (1) IL182494A (it)
IT (1) ITMI20041963A1 (it)
MA (1) MA29007B1 (it)
MX (1) MX2007004297A (it)
NO (1) NO339805B1 (it)
NZ (1) NZ554469A (it)
PL (1) PL1799214T3 (it)
PT (1) PT1799214E (it)
RS (1) RS50563B (it)
SI (1) SI1799214T1 (it)
UA (1) UA86091C2 (it)
WO (1) WO2006040004A1 (it)
ZA (1) ZA200703009B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20041963A1 (it) * 2004-10-15 2005-01-15 Luso Farmaco Inst "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"
CA2666406A1 (en) 2006-10-16 2008-04-24 Gruenenthal Gmbh Substituted sulfonamide derivatives for use as bradykinin 1 receptor modulators
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
ITMI20072225A1 (it) * 2007-11-23 2009-05-24 Luso Farmaco Inst "composizioni farmaceutiche a base di antagonisti della bradichinina ed acido ialuronico e loro uso"
IT1391236B1 (it) * 2008-07-11 2011-12-01 St Luso Farm D'italia Spa Composizioni farmaceutiche a base di antagonisti del recettore b2 delle chinine e corticosteroidi e loro uso
WO2015155323A1 (en) * 2014-04-10 2015-10-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Br2 antagonist for use in the prevention of the hypotensive effect of patient treated with angiotensin-converting enzyme inhibitors (acei)
AU2017325986B2 (en) * 2016-09-16 2023-12-14 Takeda Pharmaceutical Company Limited Metabolite biomarkers for diseases associated with the contact activation system
SG11202004653TA (en) 2017-11-24 2020-06-29 Pharvaris Netherlands B V Novel bradykinin b2 receptor antagonists
AR118983A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
AR118982A1 (es) * 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物
WO2023180577A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Therapeutic uses of bradykinin b2-receptor antagonists
WO2023180575A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Solid composition comprising solubilised bradykinin b2-receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
ITMI20041963A1 (it) * 2004-10-15 2005-01-15 Luso Farmaco Inst "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche"
EP1741444A1 (en) * 2005-07-05 2007-01-10 Jerini AG Kinin antagonists for treating bladder dysfunction

Also Published As

Publication number Publication date
ZA200703009B (en) 2008-08-27
EP1799214B1 (en) 2007-12-26
NZ554469A (en) 2010-02-26
HRP20080107T3 (en) 2008-05-31
EP1799214B8 (en) 2008-06-18
DE602005004039T2 (de) 2009-01-22
EA200700584A1 (ru) 2007-10-26
JP4980917B2 (ja) 2012-07-18
AR051392A1 (es) 2007-01-10
NO339805B1 (no) 2017-02-06
US7645759B2 (en) 2010-01-12
DE602005004039D1 (de) 2008-02-07
BRPI0515983A (pt) 2008-08-12
IL182494A (en) 2011-07-31
EP1799214A1 (en) 2007-06-27
CN101039671B (zh) 2010-10-13
PL1799214T3 (pl) 2008-05-30
HK1107263A1 (en) 2008-04-03
ATE381931T1 (de) 2008-01-15
AU2005293881B2 (en) 2010-02-25
CY1107254T1 (el) 2012-11-21
SI1799214T1 (sl) 2008-06-30
GEP20115322B (en) 2011-11-10
MX2007004297A (es) 2008-03-11
RS50563B (sr) 2010-05-07
PT1799214E (pt) 2008-03-31
CA2583920A1 (en) 2006-04-20
ES2299090T3 (es) 2008-05-16
NO20071840L (no) 2007-04-11
JP2008516901A (ja) 2008-05-22
UA86091C2 (ru) 2009-03-25
AU2005293881A1 (en) 2006-04-20
CA2583920C (en) 2013-02-12
EA010913B1 (ru) 2008-12-30
MA29007B1 (fr) 2007-11-01
DK1799214T3 (da) 2008-05-13
WO2006040004A1 (en) 2006-04-20
IL182494A0 (en) 2007-09-20
CN101039671A (zh) 2007-09-19
US20070281944A1 (en) 2007-12-06

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