DE60307677D1 - Dispergierbare pharmazeutische zusammensetzungen - Google Patents

Dispergierbare pharmazeutische zusammensetzungen

Info

Publication number
DE60307677D1
DE60307677D1 DE60307677T DE60307677T DE60307677D1 DE 60307677 D1 DE60307677 D1 DE 60307677D1 DE 60307677 T DE60307677 T DE 60307677T DE 60307677 T DE60307677 T DE 60307677T DE 60307677 D1 DE60307677 D1 DE 60307677D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
dispersible pharmaceutical
dispersible
compositions
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60307677T
Other languages
English (en)
Other versions
DE60307677T2 (de
Inventor
Nancy J Britten
Niki A Waldron
John W Burns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE60307677D1 publication Critical patent/DE60307677D1/de
Application granted granted Critical
Publication of DE60307677T2 publication Critical patent/DE60307677T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0046Ear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0041Mammary glands, e.g. breasts, udder; Intramammary administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60307677T 2002-12-19 2003-12-11 Dispergierbare pharmazeutische zusammensetzungen Expired - Lifetime DE60307677T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43498502P 2002-12-19 2002-12-19
US434985P 2002-12-19
US687986 2003-10-17
US10/687,986 US7842791B2 (en) 2002-12-19 2003-10-17 Dispersible pharmaceutical compositions
PCT/US2003/039508 WO2004060345A2 (en) 2002-12-19 2003-12-11 Dispersible pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DE60307677D1 true DE60307677D1 (de) 2006-09-28
DE60307677T2 DE60307677T2 (de) 2007-08-16

Family

ID=32717791

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60307677T Expired - Lifetime DE60307677T2 (de) 2002-12-19 2003-12-11 Dispergierbare pharmazeutische zusammensetzungen

Country Status (25)

Country Link
US (1) US7842791B2 (de)
EP (1) EP1575618B1 (de)
JP (1) JP3803683B2 (de)
KR (1) KR100752836B1 (de)
CN (1) CN100355457C (de)
AR (1) AR042537A1 (de)
AT (1) ATE336264T1 (de)
AU (1) AU2003296947B2 (de)
BR (1) BR0317104B1 (de)
CA (1) CA2504065C (de)
CY (1) CY1105202T1 (de)
DE (1) DE60307677T2 (de)
DK (1) DK1575618T3 (de)
ES (1) ES2268496T3 (de)
HK (1) HK1081457A1 (de)
MX (1) MXPA05006739A (de)
NO (1) NO20052306L (de)
NZ (1) NZ540715A (de)
PL (1) PL377518A1 (de)
PT (1) PT1575618E (de)
RU (1) RU2311201C2 (de)
SI (1) SI1575618T1 (de)
TW (1) TW200420299A (de)
WO (1) WO2004060345A2 (de)
ZA (1) ZA200504873B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
MXPA05004278A (es) 2002-10-25 2005-10-05 Foamix Ltd Espuma cosmetica y farmaceutica.
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
JP2007500691A (ja) * 2003-07-31 2007-01-18 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗炎症剤の分散性製剤
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
CN101107015B (zh) * 2005-01-19 2013-01-23 日本全药工业株式会社 乳腺炎用注入剂
KR100748252B1 (ko) 2006-05-08 2007-08-10 주식회사 삼양애니팜 플로르페니콜 및 타이로신 함유 주사용 조성물
EP2059231A1 (de) * 2006-08-30 2009-05-20 Intervet International BV Pharmazeutische zusammensetzungen mit cefquinom
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008096918A1 (en) * 2007-02-09 2008-08-14 Kolon Industries, Inc Reactive antibioties and a method of preparing the same and antibacterial fiber treated thereby
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US20100016218A1 (en) * 2008-07-14 2010-01-21 Otonomy, Inc. Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011039638A2 (en) 2009-10-02 2011-04-07 Foamix Ltd. Topical tetracycline compositions
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
CN101804058A (zh) * 2010-04-22 2010-08-18 中国农业科学院兰州畜牧与兽药研究所 一种用于防治奶牛干奶期乳房炎的药物及制备方法
MX359366B (es) * 2010-11-01 2018-09-26 Melinta Subsidiary Corp Composición farmacéutica de liberación sostenida que comprene un agente antibacterial.
CN102058612B (zh) * 2011-01-06 2012-07-04 河南亚卫动物药业有限公司 一种兽用复方乳浊液及其制备方法
US9730913B2 (en) * 2011-10-13 2017-08-15 The Johns Hopkins University High affinity beta lactamase inhibitors
KR101352867B1 (ko) 2011-11-07 2014-01-21 주식회사 한동 동물용 복합항생제 조성물
AU2013201147A1 (en) 2012-02-27 2013-09-12 Bayer New Zealand Limited Controlled release compositions and their methods of use
CN103479660A (zh) * 2012-06-14 2014-01-01 符波 一种治疗奶牛临床型乳房炎的乳房注入剂及其制备方法
KR101458611B1 (ko) * 2012-08-02 2014-11-11 주식회사 한동 동물용 복합항생제 조성물
CN105492005A (zh) * 2013-02-08 2016-04-13 罗达制药有限公司 治疗包括乳房炎的微生物感染的方法
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
CN106265595B (zh) * 2016-09-29 2019-05-03 甘肃瑞和祥生物科技有限公司 一种肠溶吉他霉素缓释微球及其制备方法
CN106361707B (zh) * 2016-09-30 2019-02-26 广东温氏大华农生物科技有限公司 一种酒石酸泰万菌素颗粒制剂及其制备方法
CN109045044B (zh) * 2018-07-04 2020-11-17 佛山市南海东方澳龙制药有限公司 一种复方药剂及其制备方法、用途
CN112716898A (zh) * 2021-02-22 2021-04-30 青岛康地恩动物药业有限公司 一种替米考星自乳化口服制剂及其制备方法

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA670254A (en) 1963-09-10 E. Gouge Hardin Mastitis composition
US3144386A (en) * 1958-05-09 1964-08-11 Merck & Co Inc Mastitis aerosol foam
GB980282A (en) 1960-03-24 1965-01-13 Philips Roxane Antibiotic mastitis composition
US3135658A (en) * 1961-10-10 1964-06-02 Merck & Co Inc Non-aqueous oleaginous aerosol foam therapy of bovine mastitis
US3347743A (en) * 1964-01-03 1967-10-17 Richardson Merrell Inc Method of treating bovine masititis
GB1089523A (en) 1964-06-25 1967-11-01 Astra Hewlett Ltd Improvements in or relating to veterinary compositions for treating mastitis
GB1181527A (en) 1966-09-21 1970-02-18 Douglas Gabriel Parizeau Composition and Method for Treating Mastitis with Therapeutic Agents.
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US3636194A (en) * 1969-10-23 1972-01-18 Douglas G Parizeau Composition and method for treating mastitis with therapeutic agents
DE2063896A1 (de) 1970-12-28 1972-07-20 Dynamit Nobel Ag, 5210 Troisdorf Salbengrundlagen auf der Basis von Triglyceriden gesättigter mittelkettiger Fettsäuren und Verfahren zu deren Herstellung
CA1052697A (en) 1974-03-29 1979-04-17 Upjohn Company (The) Composition for treating mastitis in animals
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4006138A (en) * 1975-04-11 1977-02-01 Eli Lilly And Company Crystalline form of sodium O-formylcefamandole
US4011312A (en) * 1975-06-25 1977-03-08 American Home Products Corporation Prolonged release drug form for the treatment of bovine mastitis
GB1547164A (en) * 1975-08-14 1979-06-06 Beecham Group Ltd Veterinary compositions
GB1589917A (en) 1976-11-27 1981-05-20 Beecham Group Ltd Pharmaceutical composition containing a clavulanic acid derivative
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
US4172138A (en) * 1977-03-23 1979-10-23 Rhodes Russell E Method and composition of matter for the treatment of dry cows for mastitis
US4104470A (en) * 1977-06-03 1978-08-01 Eli Lilly And Company Crystallization process for cefazolin sodium
FR2414509A1 (fr) * 1978-01-17 1979-08-10 Glaxo Group Ltd Procede de cristallisation de cefuroxime sodique
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
US4299501A (en) * 1979-08-10 1981-11-10 Ortho Pharmaceutical Corporation Continuous process for the preparation of semisolid dispersions
FR2479229B1 (fr) * 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
NL8002636A (nl) * 1980-05-08 1981-12-01 Gist Brocades Nv Solvaat van amoxicilline, werkwijze ter bereiding hiervan en werkwijze ter bereiding van injectiepreparaten uit dit solvaat.
EP0058015A3 (de) 1981-02-05 1982-08-25 Beecham Group Plc Infektionsbehandlung
JPS57134482A (en) * 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
US4400503A (en) * 1981-10-30 1983-08-23 Eli Lilly And Company Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid
JPS58198489A (ja) * 1982-05-14 1983-11-18 Meiji Seika Kaisha Ltd 7β−(2D−2−アミノ−2−カルボキシエチルチオアセトアミド)−7α−メトキシ−3−(1−メチル−1H−テトラゾ−ル−5−イル)−チオメチル−3−セフエム−4−カルボン酸ナトリウム塩の七水和物及びその製造方法
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
US4474780A (en) * 1983-07-22 1984-10-02 Eli Lilly And Company Crystalline cephalosporin
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
US4616080A (en) * 1984-07-02 1986-10-07 Eli Lilly And Company Simplified process of forming crystalline ceftazidime pentahydrate
EP0365044A3 (de) * 1984-08-02 1990-08-22 Sandoz Ag Pharmazeutische Verwendung von (NVA)2-Cyclosporin
US4902683A (en) * 1984-10-25 1990-02-20 The Upjohn Company Crystalline cephalosporin hydrohalide salts
US4937330A (en) * 1985-08-12 1990-06-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
IT1190445B (it) 1985-11-08 1988-02-16 Fatro Spa Composizioni veterinarie a base di agenti antimicrobici e loro impiego
HU194493B (en) * 1985-11-27 1988-02-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing primycin-containing colloidal basic gel and compositions comprising the same
GB8531609D0 (en) 1985-12-23 1986-02-05 Beecham Group Plc Compounds
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
CH668187A5 (de) * 1986-08-07 1988-12-15 Ciba Geigy Ag Therapeutisches system mit systemischer wirkung.
GB8621484D0 (en) 1986-09-05 1986-10-15 Norbrook Lab Ltd Intramammary infusion
US4723112A (en) 1986-09-19 1988-02-02 Tektronix, Inc. Level shift circuit for differential signals
GB8629481D0 (en) 1986-12-10 1987-01-21 Beecham Group Plc Veterinary treatment
IT1214587B (it) * 1986-12-23 1990-01-18 Giovanni Bonfanti Metodo per la produzione diprodotti cristallini puri.
ATE76874T1 (de) 1987-02-02 1992-06-15 Lilly Co Eli Verfahren zur herstellung von ceftazidimepentahydrat.
DE3869135D1 (de) * 1987-07-29 1992-04-16 Upjohn Co Kontrollierte freisetzung von antibiotika-salzen aus einem implantat.
US4898938A (en) * 1987-08-03 1990-02-06 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
US4877782A (en) * 1988-02-16 1989-10-31 The Upjohn Company Zinc ceftiofur complexes
FR2635463A1 (fr) 1988-08-19 1990-02-23 Veprol Composition pharmaceutique comportant un principe actif peu soluble dans l'eau et au moins un glyceride gelifie par au moins un polymere cellulosique
US5338761A (en) * 1988-09-29 1994-08-16 Shiseido Company Ltd. Emulsified composition
DE3919259A1 (de) 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
US5143137A (en) * 1990-03-08 1992-09-01 Rite-Hite Corporation Overlapping seal for insulated folding door
US5284662A (en) * 1990-10-01 1994-02-08 Ciba-Geigy Corp. Oral osmotic system for slightly soluble active agents
US5342612A (en) * 1991-12-20 1994-08-30 American Cyanamid Company Compositions for the treatment of mammalian diseases
US5314685A (en) * 1992-05-11 1994-05-24 Agouron Pharmaceuticals, Inc. Anhydrous formulations for administering lipophilic agents
ES2079994B1 (es) 1992-10-07 1996-08-01 Cusi Lab Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica.
GB2273443B (en) 1992-12-08 1997-01-08 Bimeda Res Dev Ltd Veterinary composition for the treatment of mastitis
WO1995031180A1 (en) 1992-12-08 1995-11-23 Bimeda Research And Development Limited A veterinary composition
CN1055090C (zh) * 1993-03-12 2000-08-02 法玛西雅厄普约翰美国公司 结晶性头孢噻夫游离酸
ES2290074T3 (es) 1993-07-19 2008-02-16 Angiotech Pharmaceuticals, Inc. Composiciones anti-angiogenicas que contienen taxol y un vehiculo no biodegradable y su uso.
US6054136A (en) * 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
US5635159A (en) 1994-08-26 1997-06-03 Abbott Laboratories Aerosol drug formulations containing polyglycolyzed glycerides
AU708540B2 (en) 1995-06-06 1999-08-05 Bayer Intellectual Property Gmbh Non-irritation, nonsensitizing, non-ototoxic otic anti-bacterial compositions
US5736151A (en) * 1996-12-09 1998-04-07 Pharmacia & Upjohn Company Antibiotic oil suspensions
JP2002513750A (ja) 1998-05-07 2002-05-14 エラン コーポレーシヨン ピーエルシー 溶媒/助溶剤を含まないマイクロエマルジョン及びエマルジョンプレ濃縮物のドラッグデリバリーシステム
AR018376A1 (es) 1998-05-26 2001-11-14 Novartis Ag Composiciones farmaceuticas que se pueden dispersar de una manera espontanea y el uso de las mismas para la manufactura de un medicamento
DE69822814T2 (de) 1998-08-18 2005-01-27 Panacea Biotec Ltd. Zusammensetzung enthaltend Cyclosporin in einem hydrophilen Träger
US6440964B1 (en) * 1998-09-30 2002-08-27 Alcon Manufacturing, Ltd. Compositions and methods for treating ophthalmic and otic infections
US6395746B1 (en) * 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6509327B1 (en) * 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
AR020660A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Composiciones antibioticas para el tratamiento de ojos, oidos y nariz
IT1303793B1 (it) 1998-11-27 2001-02-23 Promefarm S R L "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)"
GB9903547D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
GB9922710D0 (en) * 1999-09-24 1999-11-24 Bayer Ag Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatatives for the treatment of multiple sclerosis
US20010049366A1 (en) * 2000-02-09 2001-12-06 Alcon Universal Ltd. Topical solution formulations containing an antibiotic and a corticosteroid
WO2001089495A2 (en) 2000-05-19 2001-11-29 Alcon Laboratories, Inc. Antibiotic compositions containing quinolone derivatives for treatment of the eye, ear and nose
NZ524694A (en) * 2000-09-12 2005-05-27 Upjohn Co Pharmaceutical composition having modified carrier

Also Published As

Publication number Publication date
EP1575618B1 (de) 2006-08-16
NZ540715A (en) 2008-03-28
CA2504065C (en) 2010-06-29
US7842791B2 (en) 2010-11-30
HK1081457A1 (en) 2006-05-19
AR042537A1 (es) 2005-06-22
CY1105202T1 (el) 2010-03-03
US20040214752A1 (en) 2004-10-28
NO20052306D0 (no) 2005-05-11
WO2004060345A3 (en) 2004-10-07
BR0317104A (pt) 2005-10-25
KR20050084416A (ko) 2005-08-26
JP3803683B2 (ja) 2006-08-02
DE60307677T2 (de) 2007-08-16
MXPA05006739A (es) 2005-09-08
BR0317104B1 (pt) 2018-01-09
CN100355457C (zh) 2007-12-19
ATE336264T1 (de) 2006-09-15
CN1720065A (zh) 2006-01-11
AU2003296947A1 (en) 2004-07-29
CA2504065A1 (en) 2004-07-22
JP2006514955A (ja) 2006-05-18
RU2005119159A (ru) 2006-01-20
AU2003296947B2 (en) 2009-02-19
ES2268496T3 (es) 2007-03-16
WO2004060345A2 (en) 2004-07-22
NO20052306L (no) 2005-07-19
DK1575618T3 (da) 2006-11-13
KR100752836B1 (ko) 2007-08-29
PL377518A1 (pl) 2006-02-06
EP1575618A2 (de) 2005-09-21
ZA200504873B (en) 2006-04-26
TW200420299A (en) 2004-10-16
PT1575618E (pt) 2006-11-30
RU2311201C2 (ru) 2007-11-27
SI1575618T1 (sl) 2006-12-31

Similar Documents

Publication Publication Date Title
DE60307677D1 (de) Dispergierbare pharmazeutische zusammensetzungen
PT1501534E (pt) Formulacoes farmaceuticas
NO20033556L (no) Farmasöytiske formuleringer
NO20033384D0 (no) Farmasöytisk formulering
AR028204A1 (es) Composiciones farmaceuticas electrohiladas
DE60127002D1 (de) Pharmazeutische zusammensetzung
NO20052335D0 (no) Dispergerbare defracirox-tabletter
FI20011478A (fi) Farmaseuttinen koostumus
NO20033785D0 (no) Farmasöytisk formulering
PT1467724E (pt) Composicao farmaceutica orodispersavel de agomelatina
DE60210139D1 (de) Pharmazeutische zusammensetzungen enthaltend tegaserod
IS7051A (is) Lyfjasamsetningar
NO20035627D0 (no) Farmasöytisk formulering
FI20022128A0 (fi) Farmaseuttinen koostumus
DE60217390D1 (de) Bicalutamid enthaltende pharmazeutische zusammensetzung
DE60129238D1 (de) Pharmazeutische zusammensetzung
DE10291905D2 (de) Pharmazeutische Zusammensetzung
DE10107261B4 (de) Pharmazeutische Zusammensetzung
NO20044164L (no) Farmasoytiske sammensetninger
NO20043474L (no) Oralt dispersibel farmasoytisk piribedilsammensetning
EE200200689A (et) Ravimkoostised
NO20041236L (no) Farmasoytisk formulering
ITMI20020926A1 (it) Composizioni farmaceutiche riepitelizzanti
DE602004030921D1 (de) Pharmazeutische zusammensetzung
SE0200449D0 (sv) Pharmaceutical formulation

Legal Events

Date Code Title Description
8364 No opposition during term of opposition