FR2414509A1 - Procede de cristallisation de cefuroxime sodique - Google Patents

Procede de cristallisation de cefuroxime sodique

Info

Publication number
FR2414509A1
FR2414509A1 FR7900886A FR7900886A FR2414509A1 FR 2414509 A1 FR2414509 A1 FR 2414509A1 FR 7900886 A FR7900886 A FR 7900886A FR 7900886 A FR7900886 A FR 7900886A FR 2414509 A1 FR2414509 A1 FR 2414509A1
Authority
FR
France
Prior art keywords
cefuroxime
sodium
sodium cefuroxime
aqueous solution
crystallization process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7900886A
Other languages
English (en)
Other versions
FR2414509B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2414509A1 publication Critical patent/FR2414509A1/fr
Application granted granted Critical
Publication of FR2414509B1 publication Critical patent/FR2414509B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention a pour objet la préparation du céfuroxime sodique cristallin, c'est-à-dire du sel sodique de l'acide (6R, 7R)-3-carbamoyloxyméthyl-7-Ø(Z)-2- (fur-2-yl)-2-méthoxy-imino-acétamidoõcéph-3-ém-4-carboxylique. On ajoute simultanément une solution aqueuse de céfuroxime sodique et une solution aqueuse contenant des ions sodium à un milieu aqueux de cristallisation qui renferme une proportion d'ensemencement efficace de céfuroxime sodique et on récupère le céfuroxime sodique cristallin à partir du milieu de cristallisation. Production de céfuroxime sodique cristallin à l'échelle industrielle dans des conditions de stérilité, pureté et stabilité à l'état solide, suffisante en vue d'une utilisation dans les compositions pharmaceutiques.
FR7900886A 1978-01-17 1979-01-15 Procede de cristallisation de cefuroxime sodique Granted FR2414509A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB188178 1978-01-17

Publications (2)

Publication Number Publication Date
FR2414509A1 true FR2414509A1 (fr) 1979-08-10
FR2414509B1 FR2414509B1 (fr) 1983-07-08

Family

ID=9729694

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7900886A Granted FR2414509A1 (fr) 1978-01-17 1979-01-15 Procede de cristallisation de cefuroxime sodique

Country Status (7)

Country Link
US (1) US4298732A (fr)
JP (1) JPS54117492A (fr)
CH (1) CH638218A5 (fr)
DE (1) DE2901730A1 (fr)
FR (1) FR2414509A1 (fr)
IT (1) IT1162442B (fr)
NL (1) NL189762C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2464960A1 (fr) * 1979-09-10 1981-03-20 Glaxo Group Ltd Nouvelle forme non hygroscopique d'une cephalosporine sodique, son procede de preparation et son application en therapeutique

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6011491A (ja) * 1983-03-04 1985-01-21 Shionogi & Co Ltd セフアロチンナトリウムの結晶性凍結乾燥粉末の製造法
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
JPH0288824U (fr) * 1988-12-27 1990-07-13
AU1234999A (en) * 1997-11-10 1999-05-31 Gist-Brocades B.V. Crystallization of beta-lactam compounds
KR100396464B1 (ko) * 2000-12-14 2003-09-02 씨제이 주식회사 세푸록심의 나트륨염을 함유하는 약학적 조성물의 안정화방법
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
CN100384853C (zh) * 2004-05-10 2008-04-30 河北张药股份有限公司 替卡西林钠的合成方法
CN101475579B (zh) * 2009-01-20 2011-02-09 广州白云山天心制药股份有限公司 一种稳定的头孢呋辛钠及其制备方法
CN102295653A (zh) * 2010-06-28 2011-12-28 广州白云山制药股份有限公司广州白云山化学制药厂 头孢呋辛钠的一步法回收制备方法
CN102617604A (zh) * 2012-02-24 2012-08-01 天津大学 一种耦合反应结晶制备头孢呋辛钠的方法
CN103374019B (zh) * 2012-04-12 2016-08-03 珠海保税区丽珠合成制药有限公司 一种头孢呋肟钠的制备方法
CN103102357B (zh) * 2013-02-21 2016-01-13 广东立国制药有限公司 一种头孢呋辛钠的合成方法
CN112979082B (zh) * 2021-03-01 2023-01-03 安徽金轩科技有限公司 一种呋喃铵盐生产废水回收再利用工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714154A (en) * 1970-12-24 1973-01-30 Lilly Co Eli Recovery of cephalothin salts
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
US3974153A (en) * 1971-05-14 1976-08-10 Glaxo Laboratories Limited 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2464960A1 (fr) * 1979-09-10 1981-03-20 Glaxo Group Ltd Nouvelle forme non hygroscopique d'une cephalosporine sodique, son procede de preparation et son application en therapeutique

Also Published As

Publication number Publication date
FR2414509B1 (fr) 1983-07-08
NL7900356A (nl) 1979-07-19
US4298732A (en) 1981-11-03
JPS54117492A (en) 1979-09-12
CH638218A5 (de) 1983-09-15
DE2901730C2 (fr) 1992-10-01
DE2901730A1 (de) 1979-07-19
JPS638115B2 (fr) 1988-02-19
IT7947641A0 (it) 1979-01-15
NL189762B (nl) 1993-02-16
NL189762C (nl) 1993-07-16
IT1162442B (it) 1987-04-01

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