FR2444674A1 - Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio)-alkyle) de n''-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant - Google Patents

Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio)-alkyle) de n''-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant

Info

Publication number
FR2444674A1
FR2444674A1 FR7930603A FR7930603A FR2444674A1 FR 2444674 A1 FR2444674 A1 FR 2444674A1 FR 7930603 A FR7930603 A FR 7930603A FR 7930603 A FR7930603 A FR 7930603A FR 2444674 A1 FR2444674 A1 FR 2444674A1
Authority
FR
France
Prior art keywords
substituted
alcynyl
cyanoguanidine
diamino
methylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7930603A
Other languages
English (en)
Other versions
FR2444674B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2444674A1 publication Critical patent/FR2444674A1/fr
Application granted granted Critical
Publication of FR2444674B1 publication Critical patent/FR2444674B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

L'invention a trait au domaine de la chimie pharmaceutique. Elle concerne des composés de formule :
FR7930603A 1978-12-18 1979-12-13 Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio)-alkyle) de n''-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant Expired FR2444674B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/970,517 US4200578A (en) 1978-12-18 1978-12-18 Thiazole derivatives

Publications (2)

Publication Number Publication Date
FR2444674A1 true FR2444674A1 (fr) 1980-07-18
FR2444674B1 FR2444674B1 (fr) 1986-03-28

Family

ID=25517073

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7930603A Expired FR2444674B1 (fr) 1978-12-18 1979-12-13 Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio)-alkyle) de n''-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant

Country Status (24)

Country Link
US (1) US4200578A (fr)
JP (1) JPS5583768A (fr)
KR (3) KR830001920B1 (fr)
AT (1) AT375354B (fr)
AU (1) AU533014B2 (fr)
BE (1) BE880662A (fr)
CA (1) CA1133909A (fr)
CH (1) CH642956A5 (fr)
DE (1) DE2950838A1 (fr)
DK (1) DK533979A (fr)
ES (2) ES8101569A1 (fr)
FI (1) FI793904A (fr)
FR (1) FR2444674B1 (fr)
GB (1) GB2038822B (fr)
GR (1) GR73586B (fr)
HU (1) HU182461B (fr)
IE (1) IE49320B1 (fr)
IL (1) IL58960A (fr)
IT (1) IT1164076B (fr)
LU (1) LU82000A1 (fr)
NL (1) NL7909054A (fr)
SE (1) SE444680B (fr)
YU (3) YU292179A (fr)
ZA (1) ZA796814B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
GR71929B (fr) * 1979-11-13 1983-08-19 Ici Ltd
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
CA1206151A (fr) * 1981-12-28 1986-06-17 Richard P. Pioch Pyrimidone employe contre les ulceres
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
ATE84530T1 (de) * 1983-02-07 1993-01-15 Lilly Co Eli Synthese von nizatidin.
ZA869438B (en) * 1985-12-18 1988-07-27 Lilly Co Eli Synthesis of nizatidine
JPH0247453U (fr) * 1988-09-29 1990-03-30
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer
CN111974333B (zh) * 2020-08-19 2023-06-09 宁夏亚东化工有限公司 噻唑生产线及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2053175A1 (de) * 1969-10-29 1971-07-08 Smith Khne & French Laboratories, Philadelphia, Pa (V St A ) Amidindenvate und ihre pharmakologisch vertraglichen Additionssalze, Verfahren zu ihrer Herstellung und Arzneimittel, die solche Verbindungen als Wirkstoffe enthalten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4072748A (en) * 1972-09-05 1978-02-07 Smith Kline & French Laboratories Limited Certain guanidine compounds, and their use as inhibitors of histamine activity
BE804144A (fr) 1972-09-05 1974-02-28 Smith Kline French Lab Cyanoguanidines
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1553070A (en) 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
GR62452B (en) 1977-04-20 1979-04-12 Ici Ltd Preparation process of guanidine derivatives
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2053175A1 (de) * 1969-10-29 1971-07-08 Smith Khne & French Laboratories, Philadelphia, Pa (V St A ) Amidindenvate und ihre pharmakologisch vertraglichen Additionssalze, Verfahren zu ihrer Herstellung und Arzneimittel, die solche Verbindungen als Wirkstoffe enthalten

Also Published As

Publication number Publication date
SE444680B (sv) 1986-04-28
ES8106715A1 (es) 1981-09-01
US4200578A (en) 1980-04-29
DE2950838A1 (de) 1980-07-03
GR73586B (fr) 1984-03-26
AT375354B (de) 1984-07-25
AU5371679A (en) 1980-06-26
LU82000A1 (de) 1980-07-21
CA1133909A (fr) 1982-10-19
KR830001263A (ko) 1983-04-29
IE792436L (en) 1980-06-18
KR840001074B1 (ko) 1984-07-31
AU533014B2 (en) 1983-10-27
YU292179A (en) 1983-02-28
IE49320B1 (en) 1985-09-18
KR830001920B1 (ko) 1983-09-23
ATA793779A (de) 1983-12-15
JPS639512B2 (fr) 1988-02-29
NL7909054A (nl) 1980-06-20
IT7950977A0 (it) 1979-12-04
HU182461B (en) 1984-01-30
YU259382A (en) 1983-02-28
GB2038822B (en) 1983-01-19
ES487035A0 (es) 1980-12-16
BE880662A (fr) 1980-06-17
FI793904A (fi) 1980-06-19
YU259482A (en) 1983-02-28
ZA796814B (en) 1980-11-26
IT1164076B (it) 1987-04-08
SE7910392L (sv) 1980-06-19
GB2038822A (en) 1980-07-30
CH642956A5 (fr) 1984-05-15
ES8101569A1 (es) 1980-12-16
ES493718A0 (es) 1981-09-01
IL58960A0 (en) 1980-03-31
KR840004685A (ko) 1984-10-22
KR840004686A (ko) 1984-10-22
JPS5583768A (en) 1980-06-24
DK533979A (da) 1980-06-19
KR840001075B1 (ko) 1984-07-31
FR2444674B1 (fr) 1986-03-28
IL58960A (en) 1983-06-15

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