ATE60579T1 - Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten. - Google Patents

Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.

Info

Publication number
ATE60579T1
ATE60579T1 AT87117003T AT87117003T ATE60579T1 AT E60579 T1 ATE60579 T1 AT E60579T1 AT 87117003 T AT87117003 T AT 87117003T AT 87117003 T AT87117003 T AT 87117003T AT E60579 T1 ATE60579 T1 AT E60579T1
Authority
AT
Austria
Prior art keywords
derivatives
processes
antipropylene
pyrrolidinamide
preparation
Prior art date
Application number
AT87117003T
Other languages
English (en)
Inventor
Masayuki Saitoh
Takaharu Tanaka
Naoki Higuchi
Masaki Hashimoto
Harukazu Fukami
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ATE60579T1 publication Critical patent/ATE60579T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT87117003T 1986-11-18 1987-11-17 Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten. ATE60579T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61274355A JPH08806B2 (ja) 1986-11-18 1986-11-18 プロリルエンドペプチダ−ゼ阻害作用を有する新規ピロリジンアミド誘導体
EP87117003A EP0268281B1 (de) 1986-11-18 1987-11-17 Pyrrolidinamid-Derivate mit Antipropylendopeptidase-Wirkung, Zusammenstellungen, die sie enthalten, Verfahren zu ihrer Herstellung und Heilmittel, die sie enthalten

Publications (1)

Publication Number Publication Date
ATE60579T1 true ATE60579T1 (de) 1991-02-15

Family

ID=17540501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87117003T ATE60579T1 (de) 1986-11-18 1987-11-17 Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.

Country Status (9)

Country Link
US (1) US4810721A (de)
EP (1) EP0268281B1 (de)
JP (1) JPH08806B2 (de)
AT (1) ATE60579T1 (de)
AU (1) AU591860B2 (de)
CA (1) CA1326033C (de)
DE (1) DE3767839D1 (de)
ES (1) ES2036562T3 (de)
GR (1) GR3001405T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3712364A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
DE3712365A1 (de) * 1987-04-11 1988-10-27 Hoechst Ag Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung
CA2004028C (en) * 1988-12-08 1998-09-22 Motoki Torizuka Condensed benzene derivative
US5118811A (en) * 1989-04-13 1992-06-02 Japan Tobacco Inc. Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
US5073549A (en) * 1990-03-22 1991-12-17 Bristol-Myers Squibb Company BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
US4999349A (en) * 1990-03-22 1991-03-12 Bristol-Myers Squibb Co. BU-4164E - A and B, prolyl endopeptidase inhibitors
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
IT1249728B (it) * 1991-11-06 1995-03-09 Sigma Tau Ind Farmaceuti Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
IT1254471B (it) * 1992-02-27 1995-09-25 Magis Farmaceutici Derivati ammidici della (r)-glicerofosforil-(s)-serina o del suo diacil derivato, un processo per la loro preparazione e relative composizioni farmaceutiche per il potenziamento dei processi di apprendimento
JP3810097B2 (ja) * 1993-01-15 2006-08-16 明治製菓株式会社 ピロリジン−２−イルカルボニル複素環式化合物誘導体
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP2007509898A (ja) 2003-11-03 2007-04-19 プロビオドルグ エージー 神経障害治療に有用な組合せ
US7304086B2 (en) 2004-02-05 2007-12-04 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
WO2008144748A1 (en) * 2007-05-21 2008-11-27 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
KR101790806B1 (ko) 2010-03-10 2017-11-20 프로비오드룩 아게 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
JPS60172929A (ja) * 1984-02-17 1985-09-06 Yakult Honsha Co Ltd 抗健忘症剤
JPS60188317A (ja) * 1984-03-09 1985-09-25 Yakult Honsha Co Ltd 抗健忘症剤
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
IN164086B (de) * 1984-10-23 1989-01-14 Siemens Ag
JPH0680077B2 (ja) * 1985-02-08 1994-10-12 サントリー株式会社 プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
JPH0651677B2 (ja) * 1985-12-23 1994-07-06 サントリー株式会社 ジペプチド誘導体及びその製法並びに用途
JPH0764834B2 (ja) * 1985-11-29 1995-07-12 サントリー株式会社 プロリルエンドペプチダーゼ阻害活性を有する新規ピロリジンアミド誘導体およびその製法並びに用途
JPH0780883B2 (ja) * 1986-03-27 1995-08-30 住友製薬株式会社 新規なβ−ラクタム化合物
DE3780344T2 (de) * 1986-03-27 1993-01-28 Sumitomo Pharma Beta-lactam-verbindungen und deren herstellung.

Also Published As

Publication number Publication date
EP0268281A2 (de) 1988-05-25
EP0268281B1 (de) 1991-01-30
AU8133687A (en) 1988-05-19
EP0268281A3 (en) 1989-01-18
ES2036562T3 (es) 1993-06-01
GR3001405T3 (en) 1992-09-25
CA1326033C (en) 1994-01-11
US4810721A (en) 1989-03-07
AU591860B2 (en) 1989-12-14
DE3767839D1 (de) 1991-03-07
JPH08806B2 (ja) 1996-01-10
JPS63130579A (ja) 1988-06-02

Similar Documents

Publication Publication Date Title
ATE60579T1 (de) Pyrrolidinamid-derivate mit antipropylendopeptidase-wirkung, zusammenstellungen, die sie enthalten, verfahren zu ihrer herstellung und heilmittel, die sie enthalten.
FR2371436A1 (fr) Nouveaux derives de morpholine ou de piperidine utiles comme medicaments et comme fongicides
ATE25974T1 (de) Acyl-substituierte derivate von 1,2,3,4tetrahydroisochinolin-3-carboxysaeuren, ihre salze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung.
YU56995A (sh) Soli derivata indola
FR2360587A1 (fr) Nouveaux derives d'amino-alcoyl-furannes utiles comme medicaments
ATE36859T1 (de) 4'-demethyl-4-epipodophyllotoxin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
HUT42080A (en) Process for producing labdane derivatives and pharmaceutical compositions containing them
ES8606282A1 (es) Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
JPS5665869A (en) Novel 22hydroxyalkyll3*4*55trihydroxyypiperidine compound* its manufacture and drug
MY105538A (en) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
MY135774A (en) Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them.
ATE71944T1 (de) Thiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ATE62908T1 (de) Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung.
KR880007070A (ko) 백내장 치료용 약학 조성물
FR2377382A1 (fr) Nouveaux phenylazacycloalcanes utiles comme medicaments
ATE35133T1 (de) N-substituierte (bis(hydroxymethyl)-methyl>isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE61589T1 (de) Isohexid-nukleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
FR2355846A1 (fr) Esters de penicillines utilisables comme medicaments
MY106235A (en) New 2 - carbonyl substituted n, n'' -di (trimethoxybenzoyl) piperazines, process for preparing the same and therapeutical compounds containing them.
FR2380272A1 (fr) Derives de la coumarine et d'indane-diode, utilisables comme medicament
ATE34740T1 (de) (bis(hydroxymethyl)methyl)-isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE36321T1 (de) (bis(substituiertes methyl)methyl>isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
IL106934A (en) Heteroarenylpiperazines a process for their preparation and pharmaceutical compositions comprising them
NO942051L (no) Nye tiosemikarbazontioner
FR2401905A1 (fr) Nouvelles a-halogenomethylamines utiles notamment comme medicaments et procede de leur preparation

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee