ES8101569A1 - Un procedimiento para la obtencion de agentes bloqueantes dereceptor h2 de la histamina - Google Patents

Un procedimiento para la obtencion de agentes bloqueantes dereceptor h2 de la histamina

Info

Publication number
ES8101569A1
ES8101569A1 ES487035A ES487035A ES8101569A1 ES 8101569 A1 ES8101569 A1 ES 8101569A1 ES 487035 A ES487035 A ES 487035A ES 487035 A ES487035 A ES 487035A ES 8101569 A1 ES8101569 A1 ES 8101569A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
independently hydrogen
thiazole derivatives
pnr4r5
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES487035A
Other languages
English (en)
Other versions
ES487035A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES8101569A1 publication Critical patent/ES8101569A1/es
Publication of ES487035A0 publication Critical patent/ES487035A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms

Abstract

PROCEDIMIENTO DE OBTENCION DE N-ALQUINIL-N'' (OPCIONALMENTE TIAZOLIL SUSTITUIDO) METILTIO ALQUIL-DERIVADOS DE N''''-CIANOGUANIDINA Y DE 1,1-DIAMINO-2 ETILEN-SUSTITUIDO. CONSTA DE LAS SIGUIENTES ETAPAS: 1) REACCION DE UN DISOLVENTE NO REACTIVO, A TEMPERATURA IGUAL O SUPERIOR A LA AMBIENTE DE UN COMPUESTO (I), CON OTRO DE FORMULA (II) EN QUE OMEGA ES -SR'''' O NHR'' Y <<A>> ES 0 O 1. 2) CUANDO OMEGA ES -SR'''', SE HACE REACCIONAR EL COMPUESTO OBTENIDO EN LA ETAPA ANTERIOR, CON R''NH2, PARA OBTENER EL COMPUESTO (III), OBJETO DE LA INVENCION. *FORMULA* AGENTES BLOQUEANTES DEL RECEPTOR H2 DE LA HISTAMINA. AGENTE ANTI-ULCERA. L
ES487035A 1978-12-18 1979-12-18 Un procedimiento para la obtencion de agentes bloqueantes dereceptor h2 de la histamina Granted ES487035A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/970,517 US4200578A (en) 1978-12-18 1978-12-18 Thiazole derivatives

Publications (2)

Publication Number Publication Date
ES8101569A1 true ES8101569A1 (es) 1980-12-16
ES487035A0 ES487035A0 (es) 1980-12-16

Family

ID=25517073

Family Applications (2)

Application Number Title Priority Date Filing Date
ES487035A Granted ES487035A0 (es) 1978-12-18 1979-12-18 Un procedimiento para la obtencion de agentes bloqueantes dereceptor h2 de la histamina
ES493718A Expired ES8106715A1 (es) 1978-12-18 1980-07-24 Un procedimiento para la obtencion de agentes bloqueantes del receptor h2 de la histamina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES493718A Expired ES8106715A1 (es) 1978-12-18 1980-07-24 Un procedimiento para la obtencion de agentes bloqueantes del receptor h2 de la histamina

Country Status (24)

Country Link
US (1) US4200578A (es)
JP (1) JPS5583768A (es)
KR (3) KR830001920B1 (es)
AT (1) AT375354B (es)
AU (1) AU533014B2 (es)
BE (1) BE880662A (es)
CA (1) CA1133909A (es)
CH (1) CH642956A5 (es)
DE (1) DE2950838A1 (es)
DK (1) DK533979A (es)
ES (2) ES487035A0 (es)
FI (1) FI793904A (es)
FR (1) FR2444674B1 (es)
GB (1) GB2038822B (es)
GR (1) GR73586B (es)
HU (1) HU182461B (es)
IE (1) IE49320B1 (es)
IL (1) IL58960A (es)
IT (1) IT1164076B (es)
LU (1) LU82000A1 (es)
NL (1) NL7909054A (es)
SE (1) SE444680B (es)
YU (3) YU292179A (es)
ZA (1) ZA796814B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
GR71929B (es) * 1979-11-13 1983-08-19 Ici Ltd
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
CA1206151A (en) * 1981-12-28 1986-06-17 Richard P. Pioch Pyrimidone anti-ulcer agents
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
UA6020A1 (uk) * 1983-02-07 1994-12-29 Елі Ліллі Енд Компані Спосіб одержання n-метіл-n-/2-(2-діметіламінометіл тіазол-4-ілметілтіо)-етіл/-2-нітро-1,1-етендіаміна
CA1277325C (en) * 1985-12-18 1990-12-04 Bruce A. Slomski Synthesis of nizatidine
JPH0247453U (es) * 1988-09-29 1990-03-30
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer
CN111974333B (zh) * 2020-08-19 2023-06-09 宁夏亚东化工有限公司 噻唑生产线及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
BE804144A (en) 1972-09-05 1974-02-28 Smith Kline French Lab H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidines
US4072748A (en) * 1972-09-05 1978-02-07 Smith Kline & French Laboratories Limited Certain guanidine compounds, and their use as inhibitors of histamine activity
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1553070A (en) 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
NO781300L (no) 1977-04-20 1978-10-23 Ici Ltd Fremgangsmaate for fremstilling av fysiologisk aktive guanidinderivater
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Also Published As

Publication number Publication date
FI793904A (fi) 1980-06-19
SE7910392L (sv) 1980-06-19
DK533979A (da) 1980-06-19
NL7909054A (nl) 1980-06-20
IL58960A (en) 1983-06-15
KR840001075B1 (ko) 1984-07-31
DE2950838A1 (de) 1980-07-03
KR840004685A (ko) 1984-10-22
KR840004686A (ko) 1984-10-22
ZA796814B (en) 1980-11-26
BE880662A (fr) 1980-06-17
IT7950977A0 (it) 1979-12-04
YU259382A (en) 1983-02-28
ATA793779A (de) 1983-12-15
GR73586B (es) 1984-03-26
CH642956A5 (fr) 1984-05-15
AU533014B2 (en) 1983-10-27
ES493718A0 (es) 1981-09-01
JPS5583768A (en) 1980-06-24
SE444680B (sv) 1986-04-28
IT1164076B (it) 1987-04-08
CA1133909A (en) 1982-10-19
GB2038822A (en) 1980-07-30
IE49320B1 (en) 1985-09-18
ES8106715A1 (es) 1981-09-01
LU82000A1 (de) 1980-07-21
GB2038822B (en) 1983-01-19
YU259482A (en) 1983-02-28
KR840001074B1 (ko) 1984-07-31
ES487035A0 (es) 1980-12-16
IE792436L (en) 1980-06-18
KR830001263A (ko) 1983-04-29
IL58960A0 (en) 1980-03-31
KR830001920B1 (ko) 1983-09-23
FR2444674B1 (fr) 1986-03-28
FR2444674A1 (fr) 1980-07-18
YU292179A (en) 1983-02-28
HU182461B (en) 1984-01-30
AT375354B (de) 1984-07-25
AU5371679A (en) 1980-06-26
JPS639512B2 (es) 1988-02-29
US4200578A (en) 1980-04-29

Similar Documents

Publication Publication Date Title
ES8106715A1 (es) Un procedimiento para la obtencion de agentes bloqueantes del receptor h2 de la histamina
ES8606336A1 (es) Un procedimiento para la preparacion de derivados de tiazol 2,4-disustituidos
MY105494A (en) Triazole antifungal agents.
ATE23716T1 (de) 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate.
FI892787A0 (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi
ES480542A1 (es) Metodo para producir derivados de imidazol.
DE3271269D1 (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
ES8102104A1 (es) Un procedimiento para la preparacion de nuevos derivados - hete rociclicos.
HUT46313A (en) Process for producing 3/2h/-pyridazine derivatives and pharmaceutical compositions containing them as active components
ES476343A1 (es) Procedimiento para la obtencion de ciclopentan-1-aminas
MY100095A (en) 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
SE8406302L (sv) Nya aminoguanidinderivat och ett forfarande for deras framstellning
CO4910146A1 (es) Dihidropironas con actividad antiviral mejorada
ATE34394T1 (de) Therapeutisch aktive di-, tri-, tetra- und penta- aza-indene.
IL76175A (en) N-substituted tricyclic oxindole carboxamides and pharmaceutical compositions containing them
SE7907953L (sv) Substituerade furaner
DK391182A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse
ES481551A1 (es) Procedimiento de preparacion de nuevos compuestos bis (ari- loxicarboxilicos).
ES8801619A1 (es) Procedimiento para la obtencion de n-6-metoxi-5(perfluoroal-quil)-1-naftoil-n-metilglicinas y sus analogos tionaftoili- cos
ES483003A1 (es) Procedimiento de preparacion de derivados de fenil-1-pipera-zina
ES463424A1 (es) Procedimiento de preparacion de lactamas sustituidas en n.
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
IE43931L (en) Homophthalimides
ES8801205A1 (es) Un procedimiento para la produccion de una isatina y una sal de la misma
ES475596A1 (es) Procedimiento para la preparacion de derivados de fenoxial- canolaminas