ES483003A1 - Procedimiento de preparacion de derivados de fenil-1-pipera-zina - Google Patents
Procedimiento de preparacion de derivados de fenil-1-pipera-zinaInfo
- Publication number
- ES483003A1 ES483003A1 ES483003A ES483003A ES483003A1 ES 483003 A1 ES483003 A1 ES 483003A1 ES 483003 A ES483003 A ES 483003A ES 483003 A ES483003 A ES 483003A ES 483003 A1 ES483003 A1 ES 483003A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- image
- atom
- formula
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento de preparación de derivados de fenil-1- piperazina, que responden a la fórmula general (I) **(Fórmula)** en la cual R1 representa un radical S(O)mR3, S(O)nCF3 en la cual m es 0, 1 ó 2, n es 1 ó 2, R3 es un radical alcohilo de 1 a 10 átomos de carbono, y R2 representa un átomo de hidrógeno, el radical CH2-CH2-OH o un radical CH2-CH2-O- COR6, CH2-CH2-O-CONHR6 o CH2-CH2-O-R6, en los cuales R6 es un acohilo de 1 a 6 átomos de carbono, a excepción del compuesto en el cual R2 es H cuando R1 es el radical S(O)mR3 en el cual m es O y R3 es CH3; así como sus sales por adición de los ácidos farmacéuticamente aceptables.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7822672A FR2432515A1 (fr) | 1978-08-01 | 1978-08-01 | Derives de phenyl-1 piperazine et leur application en therapeutique |
| FR7833105A FR2442234A2 (fr) | 1978-08-01 | 1978-11-23 | Derives de phenyl-1 piperazine et leur application en therapeutique |
| FR7916029A FR2459797A2 (fr) | 1978-08-01 | 1979-06-22 | Derives de phenyl-1 piperazine et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES483003A1 true ES483003A1 (es) | 1980-04-16 |
Family
ID=27250847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES483003A Expired ES483003A1 (es) | 1978-08-01 | 1979-07-31 | Procedimiento de preparacion de derivados de fenil-1-pipera-zina |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5522690A (es) |
| AU (1) | AU4930979A (es) |
| BE (1) | BE877994A (es) |
| DE (1) | DE2930440A1 (es) |
| DK (1) | DK321479A (es) |
| ES (1) | ES483003A1 (es) |
| FI (1) | FI792401A (es) |
| FR (1) | FR2459797A2 (es) |
| GB (1) | GB2027703A (es) |
| GR (1) | GR69703B (es) |
| IL (1) | IL57920A0 (es) |
| IT (1) | IT1123497B (es) |
| LU (1) | LU81562A1 (es) |
| NL (1) | NL7905810A (es) |
| NO (1) | NO792502L (es) |
| NZ (1) | NZ191140A (es) |
| PT (1) | PT70007A (es) |
| SE (1) | SE7906507L (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2582288B1 (fr) * | 1985-05-21 | 1987-08-07 | Massonnet Henry | Poubelle compacteuse perfectionnee |
| SE9904723D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE9904724D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| DE602005017784D1 (de) | 2004-06-08 | 2009-12-31 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission |
| ATE469885T1 (de) | 2004-06-08 | 2010-06-15 | Nsab Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin- neurotransmission |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| CA2584831C (en) | 2004-10-13 | 2013-09-17 | Neurosearch Sweden Ab | Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine |
| SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| EP2787997A4 (en) | 2011-12-08 | 2015-05-27 | Ivax Int Gmbh | HYDROBROMIDE SALT OF PRIDOPIDINE |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH353743A (fr) * | 1955-06-29 | 1961-04-30 | Parke Davis & Co | Procédé de préparation de pipérazines |
| US2976290A (en) * | 1959-04-24 | 1961-03-21 | Parke Davis & Co | Piperazine derivatives and methods for their production |
| FR2224464A1 (en) * | 1973-04-05 | 1974-10-31 | Synthelabo | N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents |
-
1979
- 1979-06-22 FR FR7916029A patent/FR2459797A2/fr active Granted
- 1979-07-26 DE DE19792930440 patent/DE2930440A1/de not_active Withdrawn
- 1979-07-27 GB GB7926224A patent/GB2027703A/en not_active Withdrawn
- 1979-07-27 AU AU49309/79A patent/AU4930979A/en not_active Abandoned
- 1979-07-27 NZ NZ191140A patent/NZ191140A/xx unknown
- 1979-07-27 NL NL7905810A patent/NL7905810A/nl not_active Application Discontinuation
- 1979-07-27 IT IT24749/79A patent/IT1123497B/it active
- 1979-07-30 LU LU81562A patent/LU81562A1/fr unknown
- 1979-07-30 NO NO792502A patent/NO792502L/no unknown
- 1979-07-30 IL IL57920A patent/IL57920A0/xx unknown
- 1979-07-30 DK DK321479A patent/DK321479A/da not_active Application Discontinuation
- 1979-07-31 BE BE0/196538A patent/BE877994A/fr unknown
- 1979-07-31 JP JP9858679A patent/JPS5522690A/ja active Pending
- 1979-07-31 SE SE7906507A patent/SE7906507L/xx not_active Application Discontinuation
- 1979-07-31 PT PT70007A patent/PT70007A/pt unknown
- 1979-07-31 ES ES483003A patent/ES483003A1/es not_active Expired
- 1979-08-01 FI FI792401A patent/FI792401A/fi not_active Application Discontinuation
-
1980
- 1980-07-27 GR GR59710A patent/GR69703B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5522690A (en) | 1980-02-18 |
| IT1123497B (it) | 1986-04-30 |
| BE877994A (fr) | 1980-01-31 |
| LU81562A1 (fr) | 1981-03-24 |
| IL57920A0 (en) | 1979-11-30 |
| GR69703B (es) | 1982-07-09 |
| FR2459797B2 (es) | 1982-05-14 |
| NL7905810A (nl) | 1980-02-05 |
| DK321479A (da) | 1980-02-02 |
| GB2027703A (en) | 1980-02-27 |
| DE2930440A1 (de) | 1980-02-28 |
| NZ191140A (en) | 1981-01-23 |
| IT7924749A0 (it) | 1979-07-27 |
| PT70007A (fr) | 1979-08-01 |
| AU4930979A (en) | 1980-02-07 |
| NO792502L (no) | 1980-02-04 |
| FR2459797A2 (fr) | 1981-01-16 |
| SE7906507L (sv) | 1980-02-02 |
| FI792401A (fi) | 1980-02-02 |
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