FR2224464A1 - N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents - Google Patents

N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents

Info

Publication number
FR2224464A1
FR2224464A1 FR7312278A FR7312278A FR2224464A1 FR 2224464 A1 FR2224464 A1 FR 2224464A1 FR 7312278 A FR7312278 A FR 7312278A FR 7312278 A FR7312278 A FR 7312278A FR 2224464 A1 FR2224464 A1 FR 2224464A1
Authority
FR
France
Prior art keywords
analgesic
beta
hydroxy
phenyl
inflammatory agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7312278A
Other languages
French (fr)
Other versions
FR2224464B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7312278A priority Critical patent/FR2224464A1/en
Priority to FR7407276A priority patent/FR2262964B1/fr
Priority to US00457201A priority patent/US3857945A/en
Priority to SE7404563A priority patent/SE410456B/en
Priority to BE142861A priority patent/BE813317A/en
Priority to GB1503474A priority patent/GB1433993A/en
Priority to NL7404683.A priority patent/NL158385B/en
Priority to ES425030A priority patent/ES425030A1/en
Priority to DE2416585A priority patent/DE2416585C3/en
Publication of FR2224464A1 publication Critical patent/FR2224464A1/en
Application granted granted Critical
Publication of FR2224464B1 publication Critical patent/FR2224464B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Medicaments contain cpds. (I): (where R is halogen or CF3, OCF3 or SCF3 and R' is H or 1-3C alkyl) and are in forms suitable for oral, parenteral and rectal administration. (I) are prepd. by reacting a phenylpiperiazine with an haloethanol or ethylene oxide.
FR7312278A 1973-04-05 1973-04-05 N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents Granted FR2224464A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR7312278A FR2224464A1 (en) 1973-04-05 1973-04-05 N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents
FR7407276A FR2262964B1 (en) 1973-04-05 1974-03-04
US00457201A US3857945A (en) 1973-04-05 1974-04-02 Pharmaceutical compositions containing piperazine derivatives in the treatment of pain
BE142861A BE813317A (en) 1973-04-05 1974-04-04 PHARMACEUTICAL COMPOSITIONS BASED ON PIPERAZINE DERIVATIVES
SE7404563A SE410456B (en) 1973-04-05 1974-04-04 PROCEDURE FOR THE PREPARATION OF AN ADDITIONAL SALT WITH A PHARMACEUTICAL ACCEPTABLE ACID OF A PIPERAZINE DERIVATIVE
GB1503474A GB1433993A (en) 1973-04-05 1974-04-04 Pharmaceutical compositions containing piperazine derivatives
NL7404683.A NL158385B (en) 1973-04-05 1974-04-05 METHOD OF PREPARING A MEDICINAL PRODUCT BASED ON 1-HYDROXYETHYL-4-PHENYLPIPERAZINE DERIVATIVES AND FORMED MEDICINAL PRODUCT SO OBTAINED.
ES425030A ES425030A1 (en) 1973-04-05 1974-04-05 Procedure for preparing piperazine derivatives. (Machine-translation by Google Translate, not legally binding)
DE2416585A DE2416585C3 (en) 1973-04-05 1974-04-05 Medicines with analgesic and anti-inflammatory effects

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7312278A FR2224464A1 (en) 1973-04-05 1973-04-05 N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents

Publications (2)

Publication Number Publication Date
FR2224464A1 true FR2224464A1 (en) 1974-10-31
FR2224464B1 FR2224464B1 (en) 1977-08-05

Family

ID=9117462

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7312278A Granted FR2224464A1 (en) 1973-04-05 1973-04-05 N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents

Country Status (2)

Country Link
ES (1) ES425030A1 (en)
FR (1) FR2224464A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2442234A2 (en) * 1978-08-01 1980-06-20 Synthelabo CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents
FR2459797A2 (en) * 1978-08-01 1981-01-16 Synthelabo PHENYL-1 PIPERAZINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2442234A2 (en) * 1978-08-01 1980-06-20 Synthelabo CNS-active 1-phenyl-piperazine cpds. - useful as analgesics and psychotropic agents
FR2459797A2 (en) * 1978-08-01 1981-01-16 Synthelabo PHENYL-1 PIPERAZINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
FR2224464B1 (en) 1977-08-05
ES425030A1 (en) 1976-11-01

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Legal Events

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ST Notification of lapse