NL7408264A - 1-(3-Trifluoromethylphenyl)-2-(homo)morpholinopropanes - with anorectic activity - Google Patents

1-(3-Trifluoromethylphenyl)-2-(homo)morpholinopropanes - with anorectic activity

Info

Publication number
NL7408264A
NL7408264A NL7408264A NL7408264A NL7408264A NL 7408264 A NL7408264 A NL 7408264A NL 7408264 A NL7408264 A NL 7408264A NL 7408264 A NL7408264 A NL 7408264A NL 7408264 A NL7408264 A NL 7408264A
Authority
NL
Netherlands
Prior art keywords
morpholinopropanes
homo
trifluoromethylphenyl
lower alkyl
anorectic
Prior art date
Application number
NL7408264A
Other languages
Dutch (nl)
Inventor
Peter Edward Cross
Roger Peter Dickinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to NL7408264A priority Critical patent/NL7408264A/en
Priority to AU70660/74A priority patent/AU482710B2/en
Publication of NL7408264A publication Critical patent/NL7408264A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-(Homo)morpholinopropanes of formula (I) and their acid addn. salts are new: (where R is H or halogen; R1 is lower alkyl; R3 and R4 are H, lower alkyl or phenyl; R5 is H or lower alkyl; n = 1 or 2). Cpds. (I) are anorectic agents with a high anorectic/CNS depressant activity ratio (no details given).
NL7408264A 1974-06-20 1974-06-20 1-(3-Trifluoromethylphenyl)-2-(homo)morpholinopropanes - with anorectic activity NL7408264A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NL7408264A NL7408264A (en) 1974-06-20 1974-06-20 1-(3-Trifluoromethylphenyl)-2-(homo)morpholinopropanes - with anorectic activity
AU70660/74A AU482710B2 (en) 1974-06-20 1974-07-01 2-(3-trifluoromethylphenyl)alkyl morpholines and their preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL7408264A NL7408264A (en) 1974-06-20 1974-06-20 1-(3-Trifluoromethylphenyl)-2-(homo)morpholinopropanes - with anorectic activity
AU70660/74A AU482710B2 (en) 1974-06-20 1974-07-01 2-(3-trifluoromethylphenyl)alkyl morpholines and their preparation

Publications (1)

Publication Number Publication Date
NL7408264A true NL7408264A (en) 1975-12-23

Family

ID=25636381

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7408264A NL7408264A (en) 1974-06-20 1974-06-20 1-(3-Trifluoromethylphenyl)-2-(homo)morpholinopropanes - with anorectic activity

Country Status (2)

Country Link
AU (1) AU482710B2 (en)
NL (1) NL7408264A (en)

Also Published As

Publication number Publication date
AU482710B2 (en) 1976-01-08
AU7066074A (en) 1976-01-08

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Legal Events

Date Code Title Description
BI The patent application has been withdrawn