ES285855A1 - A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES285855A1
ES285855A1 ES285855A ES285855A ES285855A1 ES 285855 A1 ES285855 A1 ES 285855A1 ES 285855 A ES285855 A ES 285855A ES 285855 A ES285855 A ES 285855A ES 285855 A1 ES285855 A1 ES 285855A1
Authority
ES
Spain
Prior art keywords
general formula
see formula
formula
benzophenone
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES285855A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES285855A1 publication Critical patent/ES285855A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Process for the manufacture of benzodiazepine derivatives of the general formula ** (See formula) ** where R1 and R2 represent hydrogen or alkyl, R3 represents hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R4 and R5 individually represent alkyl, and taken together with the nitrogen atom, a monoheterocyclic ring containing at most another heteroatom plus oxygen or nitrogen, and R6 and R7 individually represent hydrogen and, taken together, an additional C-N bond, as well as its salts, process comprising: a) reacting a benzophenone of the general formula ** (See formula) ** with an amino acid of the general formula ** (See formula) ** or one of its esters, or b) reacting said benzophenone with a haloacylamide halide of the general formula ** (See formula) ** and treating 2- (alpha-halo-alkanoyl-amido) -benzophenone formed with ammonia, or c) reductively renting a compound of the general formula ** (See formula) ** where the meaning of the symbols R1, R2, R3, R4, R5, R6 and R7 is the same as stated above, reduce if desired, the 4,5-unsaturated compounds obtained and/or transform the product into a salt obtained. (Machine-translation by Google Translate, not legally binding)
ES285855A 1962-03-09 1963-03-08 A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) Expired ES285855A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US178566A US3202665A (en) 1962-03-09 1962-03-09 5-piperidino-and 5-diloweralkylamino-2-amino-benzophenones

Publications (1)

Publication Number Publication Date
ES285855A1 true ES285855A1 (en) 1963-08-16

Family

ID=22653052

Family Applications (1)

Application Number Title Priority Date Filing Date
ES285855A Expired ES285855A1 (en) 1962-03-09 1963-03-08 A procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
US (1) US3202665A (en)
AT (1) AT242157B (en)
CH (2) CH440298A (en)
ES (1) ES285855A1 (en)
GB (1) GB984707A (en)
SE (2) SE318885B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU167950B (en) * 1973-07-26 1976-01-28
US4064121A (en) * 1973-07-26 1977-12-20 Richter Gedeon Vegyeszeti Gyar Rt. Substituted nitrobenzophenone derivatives and a process for the preparation thereof
DE602005027728D1 (en) * 2004-10-19 2011-06-09 Glaxosmithkline Llc Benzodiazepine derivatives as ROCK kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893992A (en) * 1959-07-07 I ii i i
US3109843A (en) * 1963-11-05 Process for preparing
CH349986A (en) * 1954-03-03 1960-11-15 Ciba Geigy Process for the preparation of new basic substituted heterocycles
US2914563A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Therapeutic composition
US2926180A (en) * 1957-06-18 1960-02-23 Universal Oil Prod Co Condensation of aromatic ketones with carbohydrates and related materials
US2914564A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Amine derivatives of 1, 1, 2-triphenylethane
US3045008A (en) * 1960-02-16 1962-07-17 Pfizer & Co C Novel 1, 4-diazepines

Also Published As

Publication number Publication date
US3202665A (en) 1965-08-24
DE1445871A1 (en) 1969-03-13
SE317681B (en) 1969-11-24
CH457462A (en) 1968-06-15
SE318885B (en) 1969-12-22
AT242157B (en) 1965-09-10
CH440298A (en) 1967-07-31
GB984707A (en) 1965-03-03

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