ES283029A1 - Procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES283029A1
ES283029A1 ES283029A ES283029A ES283029A1 ES 283029 A1 ES283029 A1 ES 283029A1 ES 283029 A ES283029 A ES 283029A ES 283029 A ES283029 A ES 283029A ES 283029 A1 ES283029 A1 ES 283029A1
Authority
ES
Spain
Prior art keywords
translation
manufacture
machine
legally binding
google translate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES283029A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES283029A1 publication Critical patent/ES283029A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for the manufacture of benzodiazepine derivatives of the formula ** (See formula) ** wherein R represents hydrogen or methyl, R1 represents hydrogen, halogen or trifluoromethyl and R2 represents halogen or trifluoromethyl, and its salts, which process comprises reacting a benzophenone of the formula ** (See formula) ** wherein hal represents a halogen atom and R3 and R4 represent hydrogen, halogen, trifluoromethyl or nitro with ethylenediamine, nitrate, if necessary, the product obtained and/or convert the nitro compound into the corresponding halogenated compound, introduce, if desired, at any stage of the process a methyl group in position 1 and convert, if desired, the product obtained in a salt. (Machine-translation by Google Translate, not legally binding)
ES283029A 1961-12-04 1962-12-03 Procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding) Expired ES283029A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15698861A 1961-12-04 1961-12-04
US20403462A 1962-06-21 1962-06-21

Publications (1)

Publication Number Publication Date
ES283029A1 true ES283029A1 (en) 1963-06-01

Family

ID=26853725

Family Applications (1)

Application Number Title Priority Date Filing Date
ES283029A Expired ES283029A1 (en) 1961-12-04 1962-12-03 Procedure for the manufacture of benzodiazepinic derivatives (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
BE (1) BE625283A (en)
CH (2) CH457461A (en)
DE (2) DE1296638B (en)
ES (1) ES283029A1 (en)
GB (1) GB1017277A (en)
MY (1) MY6700025A (en)
OA (1) OA02393A (en)
SE (1) SE310685B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466799A (en) * 1994-08-08 1995-11-14 Iowa State University Research Foundation, Inc. Synthesis of benzodiazepines

Also Published As

Publication number Publication date
BE625283A (en) 1963-05-27
CH457461A (en) 1968-06-15
DE1695192A1 (en) 1970-03-19
MY6700025A (en) 1967-12-31
SE310685B (en) 1969-05-12
CH436315A (en) 1967-05-31
OA02393A (en) 1970-05-05
DE1296638B (en) 1969-06-04
GB1017277A (en) 1966-01-19

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