GB1017277A - Process for the manufacture of benzodiazepine derivatives - Google Patents

Process for the manufacture of benzodiazepine derivatives

Info

Publication number
GB1017277A
GB1017277A GB45099/62A GB4509962A GB1017277A GB 1017277 A GB1017277 A GB 1017277A GB 45099/62 A GB45099/62 A GB 45099/62A GB 4509962 A GB4509962 A GB 4509962A GB 1017277 A GB1017277 A GB 1017277A
Authority
GB
United Kingdom
Prior art keywords
product
halogen
group
nitro group
introducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45099/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1017277A publication Critical patent/GB1017277A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of the general formula <FORM:1017277/C2/1> (wherein R1 and R2 each represents a halogen atom or a trifluoromethyl group and the broken lines indicate that the substituents attached thereby are optional) and acid addition salts thereof are prepared by reacting a benzophenone of the formula <FORM:1017277/C2/2> (wherein R3 and R4 each represents an optional halogen, trifluoromethyl or nitro substituent) with ethylene diamine, introducing a nitro group into the reaction product where R4 is absent, replacing said nitro group and/or any nitro group(s) already present in the reaction product by halogen and, if desired, converting the product into an acid addition salt, a methylation step for the purpose of introducing a methyl group in the 1-position in the product being included at any suitable stage if desired.
GB45099/62A 1961-12-04 1962-11-29 Process for the manufacture of benzodiazepine derivatives Expired GB1017277A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15698861A 1961-12-04 1961-12-04
US20403462A 1962-06-21 1962-06-21

Publications (1)

Publication Number Publication Date
GB1017277A true GB1017277A (en) 1966-01-19

Family

ID=26853725

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45099/62A Expired GB1017277A (en) 1961-12-04 1962-11-29 Process for the manufacture of benzodiazepine derivatives

Country Status (8)

Country Link
BE (1) BE625283A (en)
CH (2) CH457461A (en)
DE (2) DE1296638B (en)
ES (1) ES283029A1 (en)
GB (1) GB1017277A (en)
MY (1) MY6700025A (en)
OA (1) OA02393A (en)
SE (1) SE310685B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466799A (en) * 1994-08-08 1995-11-14 Iowa State University Research Foundation, Inc. Synthesis of benzodiazepines

Also Published As

Publication number Publication date
SE310685B (en) 1969-05-12
DE1695192A1 (en) 1970-03-19
OA02393A (en) 1970-05-05
DE1296638B (en) 1969-06-04
CH436315A (en) 1967-05-31
MY6700025A (en) 1967-12-31
BE625283A (en) 1963-05-27
ES283029A1 (en) 1963-06-01
CH457461A (en) 1968-06-15

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