ES325546A1 - Procedure for the preparation of new biologically active derivatives of fenantridone. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new biologically active derivatives of fenantridone. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES325546A1
ES325546A1 ES0325546A ES325546A ES325546A1 ES 325546 A1 ES325546 A1 ES 325546A1 ES 0325546 A ES0325546 A ES 0325546A ES 325546 A ES325546 A ES 325546A ES 325546 A1 ES325546 A1 ES 325546A1
Authority
ES
Spain
Prior art keywords
formula
atom
radical
defined above
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0325546A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Publication of ES325546A1 publication Critical patent/ES325546A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Process for the preparation of new biologically active derivatives of phenanthridone of the formula: ** (See formula) ** or an acid addition salt thereof, in which formula R, R1 and R2 each represent a hydrogen atom or a methyl radical; R3 and R4 each represent a hydrogen atom or a lower alkyl, cycloalkyl or aralkyl radical or, together with the adjacent nitrogen atom, form a heterocyclic ring which optionally contains another heteroatom which, when it is a nitrogen atom , it can be substituted by a lower alkyl or hydroxyalkyl radical; and R5 and R6 each represent a hydrogen or halogen atom or a lower alkyl, alkoxy, trialkyl, trifluoromethyl, nitro, amino, hydroxyl, cyanide or sulfamocil radical; which method comprises the reaction of a phenanthridone of the formula: ** (See formula) ** wherein R5 and R6 are as defined above, with a compound of the formula: ** (See formula) ** wherein R1, R2 and R3 are as defined above, Y is a chlorine, bromine or iodine atom or an alkyl or aryl-sulfonyl radical and X is a chlorine atom or a group of the formula: ** (See formula) ** wherein R3 and R4 are as defined above, provided that when X is a chlorine atom, Y is a bromine atom, the reaction being carried out in the presence of a condensing agent; and then, when a compound of formula III in which X is a chlorine atom has been employed, the reaction of the resulting product with an amine of the formula: ** (See formula) ** wherein R3 and R4 are as defined above; and then, when a compound of formula I in which R3 and/or R4 is a hydrogen atom is required and the reduction of the corresponding compound of formula I, in which R3 and/or R4 is not obtained by the above method, is not required. it is an aralkyl radical; and when an acid addition salt is desired, the subsequent reaction of the resulting base with the required acid. (Machine-translation by Google Translate, not legally binding)
ES0325546A 1965-04-20 1966-04-14 Procedure for the preparation of new biologically active derivatives of fenantridone. (Machine-translation by Google Translate, not legally binding) Expired ES325546A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1666265A GB1135947A (en) 1965-04-20 1965-04-20 Novel biologically active derivatives of phenanthridone

Publications (1)

Publication Number Publication Date
ES325546A1 true ES325546A1 (en) 1967-02-16

Family

ID=10081358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0325546A Expired ES325546A1 (en) 1965-04-20 1966-04-14 Procedure for the preparation of new biologically active derivatives of fenantridone. (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
DE (1) DE1645907A1 (en)
ES (1) ES325546A1 (en)
FR (1) FR5762M (en)
GB (1) GB1135947A (en)
SE (1) SE320968B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3305329A1 (en) * 1983-02-17 1984-08-23 Hoechst Ag, 6230 Frankfurt POLYCYCLIC BISAMIDINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CHEMOTHERAPEUTICS
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides

Also Published As

Publication number Publication date
GB1135947A (en) 1968-12-11
SE320968B (en) 1970-02-23
FR5762M (en) 1968-02-05
DE1645907A1 (en) 1970-07-16

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