BE804144A - H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidines - Google Patents
H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidinesInfo
- Publication number
- BE804144A BE804144A BE135043A BE135043A BE804144A BE 804144 A BE804144 A BE 804144A BE 135043 A BE135043 A BE 135043A BE 135043 A BE135043 A BE 135043A BE 804144 A BE804144 A BE 804144A
- Authority
- BE
- Belgium
- Prior art keywords
- alkyl
- esp
- cyano
- guanidines
- oxa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
Abstract
Cpds. (I) (where R1 is H or 1-4C alkyl; and R2 is Het-(CH2)m-Z-(CH2)n- (where Het is a 5 or 6-membered N contg. heterocyclic ring esp. imidazole, pyridine, thiazole, isothiazole, oxazole, oxazole, isoxazole, pyrazole, triazole, thiadiazole, pyrimidine, pyrazine or pyridazine, opt. substd. by halogen alkyl, CF3 OH or NH2, Z is O, S or NH or CH2 and m and n are 0-4 and m+n is 2-4) are prepd. by reacting R2NH with R3-Y-C-(:NCN)NHR1 or with (R3Y)2C=N-CN (then the prodt with R1NH2) (where R3 is 1-4C alkyl, aryl, or aralkyl and Y is O or S). Thus R1=Me, R2 = 2-/(4-methyl-5-imidazolyl)me methylthio)ethyl/) is prepd. from 4-methyl-5/(2-aminoethyl)thiomethyl/imidazole and N-cyano, N', S-dimethylisothiourea.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4116072A GB1397436A (en) | 1972-09-05 | 1972-09-05 | Heterocyclic n-cyanoguinidines |
Publications (1)
Publication Number | Publication Date |
---|---|
BE804144A true BE804144A (en) | 1974-02-28 |
Family
ID=10418388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE135043A BE804144A (en) | 1972-09-05 | 1973-08-29 | H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidines |
Country Status (2)
Country | Link |
---|---|
BE (1) | BE804144A (en) |
GT (1) | GT197749830A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4112234A (en) | 1977-08-22 | 1978-09-05 | Bristol-Myers Company | Imidazolylmethylthioethyl alkynyl guanidines |
US4157347A (en) | 1977-06-03 | 1979-06-05 | Bristol-Myers Company | N-cyano isothioureas |
US4200578A (en) | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
US4250316A (en) * | 1978-11-24 | 1981-02-10 | Bristol-Myers Company | Pyridyl guanidine anti-ulcer agents |
FR2508447A1 (en) * | 1981-06-26 | 1982-12-31 | Richter Gedeon Vegyeszet | PROCESS FOR THE PREPARATION OF CIMETIDINE |
DE3223833A1 (en) * | 1981-06-26 | 1983-02-24 | Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest | 1-CYAN-2-METHYL-3- <2 '- (((5' '- METHYLIMIDAZOL-4' '- YL) -METHYL) -THIO) -AETHYL> -GUANI DINMONOHYDRATE (CIMETIDINE MONOHYDRATE) AND METHOD FOR PRODUCING THE SAME FROM 1-CYAN-2-METHYL-3- <2 '- (((5' '- METHYLIMIDAZOL-4' '-YL) -METHYL) -THIO) -AETHYL> -GUANIDIN A (CIMETIDIN A) AND THE FIRST CONTAINING IT DRUG |
USRE31588E (en) * | 1977-06-03 | 1984-05-22 | Bristol-Myers Company | Imidazolylmethylthioethyl alkynyl guanidines |
-
1973
- 1973-08-29 BE BE135043A patent/BE804144A/en not_active IP Right Cessation
-
1977
- 1977-12-12 GT GT197749830A patent/GT197749830A/en unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4157347A (en) | 1977-06-03 | 1979-06-05 | Bristol-Myers Company | N-cyano isothioureas |
USRE31588E (en) * | 1977-06-03 | 1984-05-22 | Bristol-Myers Company | Imidazolylmethylthioethyl alkynyl guanidines |
US4112234A (en) | 1977-08-22 | 1978-09-05 | Bristol-Myers Company | Imidazolylmethylthioethyl alkynyl guanidines |
US4250316A (en) * | 1978-11-24 | 1981-02-10 | Bristol-Myers Company | Pyridyl guanidine anti-ulcer agents |
US4200578A (en) | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
FR2508447A1 (en) * | 1981-06-26 | 1982-12-31 | Richter Gedeon Vegyeszet | PROCESS FOR THE PREPARATION OF CIMETIDINE |
DE3223802A1 (en) * | 1981-06-26 | 1983-01-13 | Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest | METHOD FOR PRODUCING 1-CYAN-2-METHYL-3- <2 '- (((5' '- METHYLIMIDAZOL- 4' '- YL) -METHYL) -THIO) -AETHYL> -GUANIDINE (CIMETIDINE) |
DE3223833A1 (en) * | 1981-06-26 | 1983-02-24 | Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest | 1-CYAN-2-METHYL-3- <2 '- (((5' '- METHYLIMIDAZOL-4' '- YL) -METHYL) -THIO) -AETHYL> -GUANI DINMONOHYDRATE (CIMETIDINE MONOHYDRATE) AND METHOD FOR PRODUCING THE SAME FROM 1-CYAN-2-METHYL-3- <2 '- (((5' '- METHYLIMIDAZOL-4' '-YL) -METHYL) -THIO) -AETHYL> -GUANIDIN A (CIMETIDIN A) AND THE FIRST CONTAINING IT DRUG |
Also Published As
Publication number | Publication date |
---|---|
GT197749830A (en) | 1979-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE20 | Patent expired |
Owner name: SMITH KLINE & FRENCH LABORATORIES LTD Effective date: 19930829 |