Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filedfiledCritical
Publication of BE810477ApublicationCriticalpatent/BE810477A/en
Cpds. of formula (I): (where R is 1-4C alkyl or alkoxy; Het is a 5- or 6- membered heterocycle contg. 1-4 heteroatoms (N, O or S) and opt. mono- or polysubstd. by halogen, NH2, NO2, 1-4C alkyl, 3-4C cycloalkyl, 1-4C alkoxy, 2-4C alkenyl, CF3, Ph, PhCH2, 1-4C alkylthio, mono- or di(1-4C alkyl) amino or =4C alkoxyalkyl) are prepd. by (a) acylating a 7-amino -3-(HetSCH2)-3-cephem-4-carboxylic acid (or its ester or salt) with a reactive deriv. of an N-protected 2-3(3-R-4-OH-phenyl)glycine and removing the protecting gp. or (b) reacting the corresp. 3-acetoxymethyl cephalosporin with HS-Het.
BE140443A1973-01-311974-01-313-Heterocyclyl thiomethyl cephalosporins - with broad-spectrum antibacterial activity
BE810477A
(en)
Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof
N-(6-((acylaminoacylamino or aminoacylamino)phenyl)-1,2-dihydro-2-oxonicotinyl) cephalosporin compounds, processes for their production, and compositions containing the same.