FR2346014A1 - Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity - Google Patents
Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activityInfo
- Publication number
- FR2346014A1 FR2346014A1 FR7601834A FR7601834A FR2346014A1 FR 2346014 A1 FR2346014 A1 FR 2346014A1 FR 7601834 A FR7601834 A FR 7601834A FR 7601834 A FR7601834 A FR 7601834A FR 2346014 A1 FR2346014 A1 FR 2346014A1
- Authority
- FR
- France
- Prior art keywords
- acetamido
- thiazolyl
- antibacterial activity
- hydroxyimino
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
Abstract
New cephalosporins are of formula (I) In the formula R and R1 are both H or both hydrolysable or hydrogenolysable gps. or R1 can also be opt. substd. 1-4C alkyl, A is H or an equiv. of an alkali(ne earth) metal or an amine. (I) have antibacterial activity against Gram-positive and -negative bacteria, esp. penicillin-resistant Staphylococci, E.coli, Klebsiella, Salmonella and Proteus spp. A typical cpd. is 3-acetoxymethyl-7-(2-(2-tritylamino-4-thiazolyl)-2-tritylhydroxyi- mino-acetamido)-3-cephem-4-carboxylic acid. In an example, this is prepd. starting from ethyl gamma-chloro-alpha-oximinoacetyl-acetate.
Priority Applications (93)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7601834A FR2346014A1 (en) | 1976-01-23 | 1976-01-23 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
FR7617743A FR2361893A2 (en) | 1976-01-23 | 1976-06-11 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
FR7625051A FR2361894A2 (en) | 1976-01-23 | 1976-08-18 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
SE7614678A SE440655B (en) | 1976-01-23 | 1976-12-29 | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
IL51192A IL51192A (en) | 1976-01-23 | 1976-12-31 | Oxime derivatives of 7-(amino thiazolyl)acetamido cephalosporanic acid,process for preparing them and pharmaceutical compositions containing them |
OA56044A OA05542A (en) | 1976-01-23 | 1977-01-11 | Process for the preparation of novel oximes derived from 7-amino thiazolyl acetamido cephalosporanic acid. |
ZA00770136A ZA77136B (en) | 1976-01-23 | 1977-01-11 | New oxime derivatives of 7-amino thiazolyl acetamido cephalosporanic acid,process for preparing them and pharmaceutical compositions |
ES455089A ES455089A1 (en) | 1976-01-23 | 1977-01-15 | Oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions incorporating them |
SU772439818A SU822754A3 (en) | 1976-01-23 | 1977-01-18 | Method of preparing derivatives of 7-/-2-(2-aminothiazolyl-4)-2-oxyiminoacetamido/3-acetoxymethyl-3-cephem-4-carboxylic acid in the form of sin-isomers |
SI7710137A SI7710137A8 (en) | 1976-01-23 | 1977-01-19 | Process for obtaining new oxim derivatives of 7-amino-thiazolyl- acetamido-cephalosporic acid |
AR266241A AR231985A1 (en) | 1976-01-23 | 1977-01-19 | PROCEDURE FOR THE PREPARATION OF NEW OXIMES DERIVED FROM 7-AMINO ACID TIAZOLIL CEPHALOSPORANIC ACETAMIDE, INTERMEDIARIES AND PROCEDURE FOR THE PREPARATION |
YU137/77A YU41060B (en) | 1976-01-23 | 1977-01-19 | Process for obtaining new antibiotics |
MX775372U MX4407E (en) | 1976-01-23 | 1977-01-20 | PROCEDURE TO PREPARE OXIMES DERIVED FROM 7-AMINO-TIDAZOLYL-ACETAMIDE-CEPHALOSPORANIC ACID |
MX971377U MX7126E (en) | 1976-01-23 | 1977-01-20 | PROCEDURE FOR PREPARING DERIVATIVES OF TIDAZOLYL-IMINOACETIC ACID |
IT47727/77A IT1104601B (en) | 1976-01-23 | 1977-01-20 | PROCEDURE FOR THE PRODUCTION OF OXIME DERIVED FROM 7-AMINOTHIAZOLIACETAMIDOCEPHALOSPORANIC ACID |
DD7700200629A DD132869A5 (en) | 1976-01-23 | 1977-01-21 | PROCESS FOR THE PREPARATION OF NEW AMINOTHIAZOLYLAZETAMIDO DERIVATIVES |
HURO000979 HU182568B (en) | 1976-01-23 | 1977-01-21 | Process for preparing 2-/2-amino-thiazol-4-yl/-2-oximino-acetic acid derivatives |
GB2640/77A GB1580621A (en) | 1976-01-23 | 1977-01-21 | Oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions incorporating them |
PT66099A PT66099B (en) | 1976-01-23 | 1977-01-21 | PROCESS FOR THE PREPARATION OF NEW OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID |
DE2760287A DE2760287C2 (en) | 1976-01-23 | 1977-01-21 | |
LU76624A LU76624A1 (en) | 1976-01-23 | 1977-01-21 | |
CH78777A CH622264A5 (en) | 1976-01-23 | 1977-01-21 | Process for the preparation of new oximes, syn isomers, derived from 7-(aminothiazolylacetamido)cephalosporanic acid |
DD7700197036A DD128594A5 (en) | 1976-01-23 | 1977-01-21 | PROCESS FOR THE PREPARATION OF NEW OXIM DERIVATIVES OF 7-AMINOTHIAZOLYLAZETAMIDO-ZEPHALOSPORANSAURE |
HU77RO909A HU173110B (en) | 1976-01-23 | 1977-01-21 | Process for producing oximes of 7-bracket-amino-thiazolyl-acetamido-bracket closed-3-acetoxymethyl-ceph-3-eme-4-carboxylic acid mido-skobka zakryta-3-acetoksimetil-cef-3-em-4-karbonovo |
BE174311A BE850662A (en) | 1976-01-23 | 1977-01-21 | NEW OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID |
DK023677A DK161082C (en) | 1976-01-23 | 1977-01-21 | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMER OXIMER DERIVATIVES OF 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID |
DE2702501A DE2702501C2 (en) | 1976-01-23 | 1977-01-21 | Oxime derivatives of 7-aminothiazolylacetamidocephalosporanic acid (syn isomers), their preparation and pharmaceutical compositions |
GB15561/79A GB1580623A (en) | 1976-01-23 | 1977-01-21 | 2-(2-amino-4-thiazolyl)-2-hydroxymino-acetic acid and substituted derivatives thereof useful as intermediates in the manufacture of antibiotic oxime derivatives of 7-aminothiazolyl-acetamido-cehalosporanic acid and processes for preparing them |
NZ183150A NZ183150A (en) | 1976-01-23 | 1977-01-21 | 7-aminothiazolyl-iminoa-cetamido-cephalosporin derivatives and pharmaceutical compositions |
CA000270375A CA1319682C (en) | 1976-01-23 | 1977-01-21 | Process for the preparation of new oximes derivated from 7-aminothiazolylacetamidocephalosporanic acid |
CY1123A CY1123A (en) | 1976-01-23 | 1977-01-21 | Oxime derivatives of 7-aminothiazolylacettamidocephanosporanic acid processes for preparing them and pharmaceutical compositions incorporating them |
NZ189245A NZ189245A (en) | 1976-01-23 | 1977-01-21 | Substituted 2-(2-amino-4-thiazoyl)-2-hydroxyimino-acetic acid derivatives |
DE2760123A DE2760123C2 (en) | 1976-01-23 | 1977-01-21 | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them |
DE2759895A DE2759895C2 (en) | 1976-01-23 | 1977-01-21 | Use of syn-alkoxyimino derivatives of aminothiazolylacetic acids for the preparation of corresponding 7-aminothiazolyl-syn-alkoxyiminoacetamidocephalosporanic acids |
JP504977A JPS52102293A (en) | 1976-01-23 | 1977-01-21 | Novel oxim derivative of 77 aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition |
PL1977211837A PL122968B1 (en) | 1976-01-23 | 1977-01-22 | Process for preparing novel derivatives of 2-thiazolyl-2-hydroxyiminoacetic acid |
GR52630A GR70302B (en) | 1976-01-23 | 1977-01-22 | |
PL1977195504A PL122698B1 (en) | 1976-01-23 | 1977-01-22 | Process for preparing novel oximes, derivatives of 7-amino-thazolyl-acetamido-cephalosporanic acid |
AU21579/77A AU511680B2 (en) | 1976-01-23 | 1977-01-24 | Oxime derivatives of 7-amino thiazolyl acetamido cephalosporanic acid |
IE148/77A IE45015B1 (en) | 1976-01-23 | 1977-01-24 | New oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid, processes for preparing them and pharmaceutical compositions incorporating them |
CS45277A CS207575B2 (en) | 1976-01-23 | 1977-01-24 | Method of preparation of new oxime derivates of the 7-aminothiazolylacetamidocephalsporan acid |
NL7700706A NL7700706A (en) | 1976-01-23 | 1977-01-24 | PROCESS FOR THE PREPARATION OF NEW OXIMES DERIVED FROM 7-AMINOTHIAZOLYL-ACEETAMIDO CEPHALOSPORANIC ACID. |
IE2395/81A IE45016B1 (en) | 1976-01-23 | 1977-01-24 | 2-(2-amino-4-thiazolyl)-2-hydroxyiminoacedtic acid and substituted derivatives thereof useful as intermediates in the manufacture of antibiotic oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid, and processes for preparing them |
AT41277A AT355205B (en) | 1976-01-23 | 1977-01-24 | METHOD FOR PRODUCING NEW OXIMES OF 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID AND THEIR SALTS |
FR7707307A FR2383188A2 (en) | 1976-01-23 | 1977-03-11 | Oximes of thiazolyl-acetamido cephalosporins - useful as antibacterials against Gram positive and negative species |
BE176189A BE852971R (en) | 1976-01-23 | 1977-03-29 | NEW OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID |
GB13839/77A GB1580622A (en) | 1976-01-23 | 1977-04-01 | Oxime derivatives of 7-amino-thiazolyl-acetamido-cephalosporanic acid processes for their preparation and pharmaceutical compositions containing them |
DE19772714747 DE2714747A1 (en) | 1976-01-23 | 1977-04-01 | NEW OXIMES OF 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORIC ACID, MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITIONS AND APPLICATION AS A DRUG |
US05/817,114 US4152432A (en) | 1976-01-23 | 1977-07-19 | 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives |
ES466539A ES466539A1 (en) | 1976-01-23 | 1978-02-01 | Oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid processes for preparing them and pharmaceutical compositions incorporating them |
LU79216A LU79216A1 (en) | 1976-01-23 | 1978-03-10 | PROCESS FOR THE PREPARATION OF NEW OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID |
US05/917,985 US4283396A (en) | 1976-01-23 | 1978-06-22 | 3-Acetoxymethyl-7-(hydroxyiminoacetamido)-cephalosporanic acid derivatives |
US05/920,704 US4196205A (en) | 1976-01-23 | 1978-06-30 | 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives |
CS786884A CS207577B2 (en) | 1976-01-23 | 1978-10-23 | Method of making the derivatives of the 2-/2-amino-4-thiazolyl/-vinegar acid |
AT0209479A AT373592B (en) | 1976-01-23 | 1979-03-20 | METHOD FOR PRODUCING NEW 4-THIAZOLYL OXIMES |
IL57445A IL57445A0 (en) | 1976-01-23 | 1979-05-31 | Novel thiazolyl compounds |
CH1074579A CH621347A5 (en) | 1976-01-23 | 1979-12-04 | Process for the preparation of substituted 2-(2-amino-4-thiazolyl)acetic acid oximes |
JP3097080A JPS55147290A (en) | 1976-01-23 | 1980-03-13 | Novel oxime derivative of 77aminothiazolylacetamidocephalosporanic acid* its manufacture and pharmaceutic composition |
AU56672/80A AU541985B2 (en) | 1976-01-23 | 1980-03-20 | Derivatives of 2-(-2-amino-4-thiazolyl)-2-imino acetic acid |
NLAANVRAGE8003189,A NL185208C (en) | 1976-01-23 | 1980-10-31 | PROCESS FOR PREPARING A MEDICINAL PRODUCT WITH ANTIBACTERIAL ACTION BASED ON AN ANTIBIOTIC ACTIVE 7- (2- (2 AMINO-4-THIAZOLYL) ACETAMIDO) CEF-3-EM-4-CARBONIC ACID COMPOUND. |
CH215181A CH628038A5 (en) | 1976-01-23 | 1981-03-30 | Process for the preparation of syn oximes of substituted 2-(2-amino-4-thiazolyl)acetic acids |
US06/257,984 US4376203A (en) | 1976-01-23 | 1981-04-27 | Novel 3-acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives |
JP56119432A JPS5762288A (en) | 1976-01-23 | 1981-07-31 | Novel oxime derivative of 7-aminothiazolylacetamidocephalosporanic acid, manufacture and pharmaceutical composition |
HK503/81A HK50381A (en) | 1976-01-23 | 1981-10-22 | New oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid,processes for preparing them and pharmaceutical compositions incorporating them |
GT198172848A GT198172848A (en) | 1976-01-23 | 1981-12-15 | PROCEDURE FOR THE PREPARATION OF NEW OXIMES DERIVED FROM ACID 7-AMINO-TIAZOLIL-ACETAMIDO-CEPHALOSPORANIC. |
SE8204893A SE455307B (en) | 1976-01-23 | 1982-08-26 | 2-AMINO-4-THIAZOLYL-OXIIMINO-ETHYAC ACID DERIVATIVES FOR USE AS AN INTERMEDIATE TO THE SIMILAR CEPHALOSPORINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF |
YU196782A YU44030B (en) | 1976-01-23 | 1982-08-31 | Process for obtaining thiazole derivatives |
SI8211967A SI8211967A8 (en) | 1976-01-23 | 1982-08-31 | Process for preparation of thiazole derivatives |
SI8211966A SI8211966A8 (en) | 1976-01-23 | 1982-08-31 | Process for preparation of thiazole derivatives |
YU196682A YU44031B (en) | 1976-01-23 | 1982-08-31 | Process for obtaining thiazole derivatives |
AT357782A AT378190B (en) | 1976-01-23 | 1982-09-27 | METHOD FOR PRODUCING NEW OXIMES |
US06/449,680 US4843164A (en) | 1976-01-23 | 1982-12-14 | Aminothiazolyl acetic acid derivatives |
SI8310011A SI8310011A8 (en) | 1976-01-23 | 1983-01-04 | Process for obtaining new antibiotics |
YU11/83A YU43143B (en) | 1976-01-23 | 1983-01-04 | Process for obtaining new antibiotics |
YU00012/83A YU1283A (en) | 1976-01-23 | 1983-01-04 | Process for obtaining new antibiotics |
DK242483A DK160872C (en) | 1976-01-23 | 1983-05-30 | 2-AMINO-4-THIAZOLYL-OXYIMINO ACETIC ACID DERIVATIVES USED AS INTERMEDIATES FOR THE PREPARATION OF SIMILAR CEPHALOSPORINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF |
KE3365A KE3365A (en) | 1976-01-23 | 1984-01-11 | New oxime derivatives of 7-aminothiazolylacetamido-cephalosporanic acid,processes for preparing them and pharmaceutical compositions incorporating them |
JP59202156A JPS60105670A (en) | 1976-01-23 | 1984-09-28 | Novel oxime derivative of aminothiazolylacetic acid |
MY417/85A MY8500417A (en) | 1976-01-23 | 1985-12-30 | New oxime derivatives of 7-amino thiazolyca-cetamido-cephalosporanic acid, processes for preparing them and pharmaceutical compositions incorporating them |
JP61154285A JPS6226222A (en) | 1976-01-23 | 1986-07-02 | Bacterial infection remedy |
JP61154284A JPS6230787A (en) | 1976-01-23 | 1986-07-02 | Novel oxime derivative of 7-aminothiazolylacetamidocephalosporanic acid |
JP62005195A JPS62181248A (en) | 1976-01-23 | 1987-01-14 | 2-(2-aminothiazolyl)-2-hydroxyiminoacetic acid derivative and manufacture |
JP62130077A JPS6339869A (en) | 1976-01-23 | 1987-05-28 | Novel oxime derivative of aminothiazolylacetic acid and its production |
US07/359,870 US4988816A (en) | 1976-01-23 | 1989-05-31 | Novel 3-acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives |
JP2101872A JPH03204868A (en) | 1976-01-23 | 1990-04-19 | Novel oxime derivative of aminothiazolyl- acetic acid |
US07/582,386 US5103012A (en) | 1976-01-23 | 1990-09-13 | 3-acetoxymethyl-7-(iminoacetamino)-cephalosporanic acid derivatives |
US07/777,614 US5336776A (en) | 1976-01-23 | 1991-10-16 | 3-acetoxymethyl-7-(iminoacetamideo)-cephalosporanic acid |
JP5023427A JPH05247013A (en) | 1976-01-23 | 1993-01-20 | Novel oxime derivative of aminothiazolyl acetic acid and preparation thereof |
GEAP19931537A GEP19970783B (en) | 1976-01-23 | 1993-09-09 | Process for the preparation of new oxime derivatives of 7-amino-thiazolyl-acetamido-cephalosporin acid |
HR931343A HRP931343B1 (en) | 1976-01-23 | 1993-10-29 | Process for the preparation of thiazole derivatives |
HR931342A HRP931342B1 (en) | 1976-01-23 | 1993-10-29 | Process for the preparation of new oxime derivatives of 7-amino-thiazolyl-acetamido-cephalosporin acid |
HR931341A HRP931341B1 (en) | 1976-01-23 | 1993-10-29 | Process for the preparation of thiazole derivatives |
MD94-0268A MD227C2 (en) | 1976-01-23 | 1994-09-08 | Method of 7-(2-(2-aminothiazolyl-4)-2-oxyiminoacetamido)-3-acetoxymethyl-3-cefem-4-carbonic acid preparation in the form of sin-isomers |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7601834A FR2346014A1 (en) | 1976-01-23 | 1976-01-23 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2346014A1 true FR2346014A1 (en) | 1977-10-28 |
FR2346014B1 FR2346014B1 (en) | 1979-10-05 |
Family
ID=9168296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7601834A Granted FR2346014A1 (en) | 1976-01-23 | 1976-01-23 | Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity |
Country Status (5)
Country | Link |
---|---|
JP (7) | JPS55147290A (en) |
FR (1) | FR2346014A1 (en) |
GT (1) | GT198172848A (en) |
PL (1) | PL122968B1 (en) |
ZA (1) | ZA77136B (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2348219A1 (en) * | 1976-04-12 | 1977-11-10 | Fujisawa Pharmaceutical Co | PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY |
FR2348218A1 (en) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | NEW CEPHALOSPORIN DERIVATIVES WITH A NEW 7-ACYL GROUP AND THEIR MANUFACTURING PROCESS |
DE2727753A1 (en) * | 1976-09-08 | 1978-03-16 | Takeda Chemical Industries Ltd | NEW CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THE SAME |
FR2385722A1 (en) * | 1977-04-02 | 1978-10-27 | Hoechst Ag | NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
FR2399418A1 (en) * | 1977-03-14 | 1979-03-02 | Fujisawa Pharmaceutical Co | Heterocyclyl-imino-acetamido-cephalosporin derivs. |
FR2444032A2 (en) * | 1978-12-13 | 1980-07-11 | Roussel Uclaf | 2-Thiazolyl-2-vinyloxy-imino-acetamido-cephalosporin derivs. - useful as antibacterials effective against Gram positive and negative bacteria |
FR2445830A1 (en) * | 1979-01-05 | 1980-08-01 | Roussel Uclaf | 7-Amino-thiazolyl-acetamido-cephalosporin oxime derivs. - are broad spectrum antibacterials useful against penicillin resistant Staphylococci (BE 25.9.78) |
FR2475043A2 (en) * | 1980-02-06 | 1981-08-07 | Roussel Uclaf | Amino:thiazolyl hydroxy:imino acetic ester(s) - protected on the amino gp. are intermediates for cephalosporanic acid antibiotics |
FR2475545A1 (en) * | 1980-02-12 | 1981-08-14 | Rhone Poulenc Ind | 7-Amino-thiazolyl methoxy-imino acetamido 3-thio-vinyl-cephalosporin - antibacterials active against Gram negative and Gram positive bacteria |
FR2482594A2 (en) * | 1980-05-13 | 1981-11-20 | Rhone Poulenc Ind | 2-Amino-thiazol-4-yl alpha-oximino-acetyl:thioalkyl cpds. - useful as side chains for broad spectrum antibacterials |
EP0049855A2 (en) * | 1980-10-10 | 1982-04-21 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2408613A2 (en) * | 1977-07-19 | 1979-06-08 | Roussel Uclaf | NEW OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
NL8100539A (en) | 1980-02-12 | 1981-09-01 | Rhone Poulenc Ind | NEW THIOLESTERS, THEIR PREPARATION AND THEIR USE IN SYNTHESIS. |
JPS61171464A (en) * | 1985-01-23 | 1986-08-02 | Dai Ichi Seiyaku Co Ltd | Production of oxyiminobutyric acid derivative |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
-
1976
- 1976-01-23 FR FR7601834A patent/FR2346014A1/en active Granted
-
1977
- 1977-01-11 ZA ZA00770136A patent/ZA77136B/en unknown
- 1977-01-22 PL PL1977211837A patent/PL122968B1/en unknown
-
1980
- 1980-03-13 JP JP3097080A patent/JPS55147290A/en active Granted
-
1981
- 1981-07-31 JP JP56119432A patent/JPS5762288A/en active Granted
- 1981-12-15 GT GT198172848A patent/GT198172848A/en unknown
-
1984
- 1984-09-28 JP JP59202156A patent/JPS60105670A/en active Pending
-
1986
- 1986-07-02 JP JP61154284A patent/JPS6230787A/en active Granted
- 1986-07-02 JP JP61154285A patent/JPS6226222A/en active Granted
-
1987
- 1987-01-14 JP JP62005195A patent/JPS62181248A/en active Pending
- 1987-05-28 JP JP62130077A patent/JPS6339869A/en active Granted
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2348219A1 (en) * | 1976-04-12 | 1977-11-10 | Fujisawa Pharmaceutical Co | PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY |
FR2348218A1 (en) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | NEW CEPHALOSPORIN DERIVATIVES WITH A NEW 7-ACYL GROUP AND THEIR MANUFACTURING PROCESS |
DE2760448C2 (en) * | 1976-09-08 | 1989-06-22 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
DE2727753A1 (en) * | 1976-09-08 | 1978-03-16 | Takeda Chemical Industries Ltd | NEW CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THE SAME |
FR2399418A1 (en) * | 1977-03-14 | 1979-03-02 | Fujisawa Pharmaceutical Co | Heterocyclyl-imino-acetamido-cephalosporin derivs. |
FR2385722A1 (en) * | 1977-04-02 | 1978-10-27 | Hoechst Ag | NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
FR2444032A2 (en) * | 1978-12-13 | 1980-07-11 | Roussel Uclaf | 2-Thiazolyl-2-vinyloxy-imino-acetamido-cephalosporin derivs. - useful as antibacterials effective against Gram positive and negative bacteria |
FR2445830A1 (en) * | 1979-01-05 | 1980-08-01 | Roussel Uclaf | 7-Amino-thiazolyl-acetamido-cephalosporin oxime derivs. - are broad spectrum antibacterials useful against penicillin resistant Staphylococci (BE 25.9.78) |
FR2475043A2 (en) * | 1980-02-06 | 1981-08-07 | Roussel Uclaf | Amino:thiazolyl hydroxy:imino acetic ester(s) - protected on the amino gp. are intermediates for cephalosporanic acid antibiotics |
FR2475545A1 (en) * | 1980-02-12 | 1981-08-14 | Rhone Poulenc Ind | 7-Amino-thiazolyl methoxy-imino acetamido 3-thio-vinyl-cephalosporin - antibacterials active against Gram negative and Gram positive bacteria |
FR2482594A2 (en) * | 1980-05-13 | 1981-11-20 | Rhone Poulenc Ind | 2-Amino-thiazol-4-yl alpha-oximino-acetyl:thioalkyl cpds. - useful as side chains for broad spectrum antibacterials |
EP0049855A2 (en) * | 1980-10-10 | 1982-04-21 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation |
EP0049855A3 (en) * | 1980-10-10 | 1983-07-06 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates for their preparation |
Also Published As
Publication number | Publication date |
---|---|
PL122968B1 (en) | 1982-09-30 |
JPS5762288A (en) | 1982-04-15 |
JPS6339869A (en) | 1988-02-20 |
JPS638117B2 (en) | 1988-02-19 |
JPH0419229B2 (en) | 1992-03-30 |
JPS638107B2 (en) | 1988-02-19 |
ZA77136B (en) | 1978-02-22 |
JPH0246565B2 (en) | 1990-10-16 |
FR2346014B1 (en) | 1979-10-05 |
JPS6230787A (en) | 1987-02-09 |
JPS55147290A (en) | 1980-11-17 |
JPS6226222A (en) | 1987-02-04 |
JPS62181248A (en) | 1987-08-08 |
GT198172848A (en) | 1983-06-08 |
JPS60105670A (en) | 1985-06-11 |
JPH0246596B2 (en) | 1990-10-16 |
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