ES8801619A1 - Procedimiento para la obtencion de n-6-metoxi-5(perfluoroal-quil)-1-naftoil-n-metilglicinas y sus analogos tionaftoili- cos - Google Patents
Procedimiento para la obtencion de n-6-metoxi-5(perfluoroal-quil)-1-naftoil-n-metilglicinas y sus analogos tionaftoili- cosInfo
- Publication number
- ES8801619A1 ES8801619A1 ES548914A ES548914A ES8801619A1 ES 8801619 A1 ES8801619 A1 ES 8801619A1 ES 548914 A ES548914 A ES 548914A ES 548914 A ES548914 A ES 548914A ES 8801619 A1 ES8801619 A1 ES 8801619A1
- Authority
- ES
- Spain
- Prior art keywords
- naphtolyl
- metylglycines
- thionaphthoyl
- perfluoroalkyl
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE N-6-METOXI-5(PERFLUOROALQUIL)-1-NAFTOIL-N-METILGLICINAS Y SUS ANALOGOS TIONAFTOILICOS, DE FORMULA GENERAL (I). COMPRENDE LAS OPERACIONES DE PERFLUOROALQUILAR, MEDIANTE YODURO DE PERFLUOROALQUILO, EL ACIDO 6-METOXI-5-YODO-1-NAFTALEN CARBOXILICO, DE FORMULA GENERAL (II), PARA OBTENER EL CORRESPONDIENTE COMPUESTO DE PERFLUOROALQUILO; DE HIDROLIZAR DICHO COMPUESTO PARA OBTENER EL CORRESPONDIENTE ACIDO CARBOXILICO; DE ACOPLAR EL ACIDO CARBOXILICO CON EL METILESTER DE LA SARCOSINA, PARA FORMAR EL ESTER METILICO DE LA N-METILGLICINA CORRESPONDIENTE SUSTITUIDO DE FORMULA GENERAL (III); Y DE HIDROLIZAR DICHO ESTER METILICO DE N-METILGLICINA SUSTITUIDO. DE APLICACION EN EL TRATAMIENTO DE LA DIABETES MELLITUS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/672,015 US4604406A (en) | 1984-11-16 | 1984-11-16 | N-[6-methoxy-5-(perfluoroalkyl)-1-naphtholyl]-N-methylglycines and their thionaphthoyl analogs |
Publications (2)
Publication Number | Publication Date |
---|---|
ES548914A0 ES548914A0 (es) | 1988-02-16 |
ES8801619A1 true ES8801619A1 (es) | 1988-02-16 |
Family
ID=24696806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES548914A Expired ES8801619A1 (es) | 1984-11-16 | 1985-11-15 | Procedimiento para la obtencion de n-6-metoxi-5(perfluoroal-quil)-1-naftoil-n-metilglicinas y sus analogos tionaftoili- cos |
Country Status (18)
Country | Link |
---|---|
US (1) | US4604406A (es) |
EP (1) | EP0182499B1 (es) |
JP (1) | JPH0611739B2 (es) |
KR (1) | KR900006128B1 (es) |
AT (1) | ATE42091T1 (es) |
AU (1) | AU583311B2 (es) |
CA (1) | CA1253520A (es) |
DE (1) | DE3569367D1 (es) |
DK (1) | DK166147C (es) |
ES (1) | ES8801619A1 (es) |
GE (1) | GEP19981385B (es) |
GR (1) | GR852726B (es) |
HU (1) | HU194159B (es) |
IE (1) | IE58620B1 (es) |
PH (1) | PH21450A (es) |
SU (1) | SU1468897A1 (es) |
UA (1) | UA7051A1 (es) |
ZA (1) | ZA858186B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4699993A (en) * | 1985-12-12 | 1987-10-13 | Ethyl Corporation | Perfluoroalkylnaphthalene compounds |
US4822904A (en) * | 1985-12-12 | 1989-04-18 | Ethyl Corporation | Perfluoroalkylation process |
US4734435A (en) * | 1986-04-07 | 1988-03-29 | American Home Products Corp. | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof |
JPS6399057A (ja) * | 1986-06-27 | 1988-04-30 | Nippon Shinyaku Co Ltd | グリシン誘導体 |
US4731380A (en) * | 1986-08-26 | 1988-03-15 | American Home Products Corporation (Del.) | Tolerstat as an agent for diabetic periodontitis |
EP0306525A4 (en) * | 1987-03-20 | 1991-04-24 | Alcon Laboratories Inc | Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus |
JP2548258Y2 (ja) * | 1990-12-21 | 1997-09-17 | ペガサスミシン製造株式会社 | 自動口伏せ縫い装置 |
US5388146A (en) * | 1991-11-12 | 1995-02-07 | Microlog Corporation | Automated telephone system using multiple languages |
US5337844A (en) * | 1992-07-16 | 1994-08-16 | Baker Hughes, Incorporated | Drill bit having diamond film cutting elements |
US20150057452A1 (en) | 2012-04-04 | 2015-02-26 | Catylix, Inc. | Selective androgen receptor modulators |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4254108A (en) * | 1979-11-08 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | Thioxo-1H-benz[de]isoquinoline-2(3H)-acetic acid derivatives and antidiabetic use thereof |
US4254109A (en) * | 1979-11-08 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 1H-Benz[de]isoquinoline-2(3H)-acetic acid derivatives |
CA1191156A (en) * | 1981-10-15 | 1985-07-30 | Francesco Bellini | N-((6-(lower alkoxy)-5-(trifluoromethylthio)-1- naphthalenyl)-thioxomethyl)-n-(lower alkyl)glycines |
AU544067B2 (en) * | 1981-03-02 | 1985-05-16 | Wyeth-Ayerst Canada Inc. | Thioamides and amides. treatment of diabetes |
CA1182472A (en) * | 1981-03-02 | 1985-02-12 | Kazimir Sestanj | N-[(2-naphthalenyl)thioxomethyl]glycine derivatives |
CA1176269A (en) * | 1981-03-02 | 1984-10-16 | Kazimir Sestanj | N-naphthoylglycine derivatives |
CA1147739A (en) * | 1981-03-02 | 1983-06-07 | Kazimir Sestanj | N-(naphthalenylthioxomethyl)aminoacid derivatives |
US4369188A (en) * | 1981-07-17 | 1983-01-18 | Ayerst, Mckenna & Harrison Inc. | 2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives |
-
1984
- 1984-11-16 US US06/672,015 patent/US4604406A/en not_active Expired - Lifetime
-
1985
- 1985-10-17 EP EP85307485A patent/EP0182499B1/en not_active Expired
- 1985-10-17 DE DE8585307485T patent/DE3569367D1/de not_active Expired
- 1985-10-17 AT AT85307485T patent/ATE42091T1/de active
- 1985-10-21 IE IE259885A patent/IE58620B1/en not_active IP Right Cessation
- 1985-10-23 AU AU48981/85A patent/AU583311B2/en not_active Ceased
- 1985-10-24 ZA ZA858186A patent/ZA858186B/xx unknown
- 1985-11-07 PH PH33029A patent/PH21450A/en unknown
- 1985-11-11 SU SU853976227A patent/SU1468897A1/ru active
- 1985-11-11 UA UA3976227A patent/UA7051A1/uk unknown
- 1985-11-12 KR KR1019850008427A patent/KR900006128B1/ko not_active IP Right Cessation
- 1985-11-12 CA CA000495045A patent/CA1253520A/en not_active Expired
- 1985-11-12 JP JP60254600A patent/JPH0611739B2/ja not_active Expired - Lifetime
- 1985-11-12 HU HU854321A patent/HU194159B/hu not_active IP Right Cessation
- 1985-11-12 GR GR852726A patent/GR852726B/el unknown
- 1985-11-15 DK DK529585A patent/DK166147C/da not_active IP Right Cessation
- 1985-11-15 ES ES548914A patent/ES8801619A1/es not_active Expired
-
1993
- 1993-12-10 GE GEAP19931683A patent/GEP19981385B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK166147C (da) | 1993-08-09 |
PH21450A (en) | 1987-10-28 |
DK166147B (da) | 1993-03-15 |
ZA858186B (en) | 1987-06-24 |
KR860004010A (ko) | 1986-06-16 |
CA1253520A (en) | 1989-05-02 |
JPS61122256A (ja) | 1986-06-10 |
JPH0611739B2 (ja) | 1994-02-16 |
ATE42091T1 (de) | 1989-04-15 |
GR852726B (es) | 1986-03-13 |
DE3569367D1 (en) | 1989-05-18 |
HU194159B (en) | 1988-01-28 |
IE852598L (en) | 1986-05-16 |
AU4898185A (en) | 1986-05-22 |
UA7051A1 (uk) | 1995-03-31 |
DK529585A (da) | 1986-05-17 |
HUT42059A (en) | 1987-06-29 |
EP0182499B1 (en) | 1989-04-12 |
AU583311B2 (en) | 1989-04-27 |
DK529585D0 (da) | 1985-11-15 |
ES548914A0 (es) | 1988-02-16 |
KR900006128B1 (ko) | 1990-08-24 |
IE58620B1 (en) | 1993-10-20 |
EP0182499A1 (en) | 1986-05-28 |
US4604406A (en) | 1986-08-05 |
SU1468897A1 (ru) | 1989-03-30 |
GEP19981385B (en) | 1998-11-10 |
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