ES8303395A1 - "procedimiento de preparar compuestos benzoxepinicos y analogos". - Google Patents
"procedimiento de preparar compuestos benzoxepinicos y analogos".Info
- Publication number
- ES8303395A1 ES8303395A1 ES512045A ES512045A ES8303395A1 ES 8303395 A1 ES8303395 A1 ES 8303395A1 ES 512045 A ES512045 A ES 512045A ES 512045 A ES512045 A ES 512045A ES 8303395 A1 ES8303395 A1 ES 8303395A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- medicaments
- sulfur
- preparation
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 150000005119 benzoxepines Chemical class 0.000 title 1
- 150000002829 nitrogen Chemical class 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002431 aminoalkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS BENZOXEPINICOS Y ANALOGOS, DEL TIPO QUE RESPONDEN A LA FORMULA GENERAL (I), EN LA QUE X ES OXIGENO O AZUFRE; R A R Y R'' A R'' REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O HALOGENO, UN RADICAL ALQUIL, ARIL O ACILOXI, UN RADICAL HIDROXI, UN RADICAL AMINO O DIALQUILAMINO, O UN RADICAL HIDROXIALQUIL, AMINOALCOXI O DIALQUILAMINOALCOXI, EN FORMA DE ISOMERO O EN FORMA DE MEZCLA RACEMICA. CONSISTE EN DESHIDRATAR UN COMPUESTO DE FORMULA (II) O EN DESCARBOXILAR UN COMPUESTO DE FORMULA (III), EN LA CUAL R'''' ES UN RADICAL ALQUILO. LA DESHIDRATACION SE REALIZA EN PRESENCIA DE ACIDO P-TOLUENSULFONICO Y LA DESCARBOXILACION SE REALIZA EN PRESENCIA DE CROMITO DE COBRE Y QUINOLEINA. DE APLICACION EN MEDICINA POR SUS PROPIEDADES FARMACOLOGICAS EN EL CAMPO CARDIOVASCULAR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8109327 | 1981-05-11 | ||
| FR8207693A FR2526429A1 (fr) | 1982-05-04 | 1982-05-04 | Nouveaux composes de la serie des benzoxepines et analogues soufres et azotes, leurs procedes de preparation et utilisations en tant que medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES512045A0 ES512045A0 (es) | 1983-03-01 |
| ES8303395A1 true ES8303395A1 (es) | 1983-03-01 |
Family
ID=26222386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES512045A Expired ES8303395A1 (es) | 1981-05-11 | 1982-05-10 | "procedimiento de preparar compuestos benzoxepinicos y analogos". |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4436749A (es) |
| EP (1) | EP0067086B1 (es) |
| AU (1) | AU548253B2 (es) |
| CA (1) | CA1196637A (es) |
| DE (1) | DE3267884D1 (es) |
| ES (1) | ES8303395A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2538250A1 (fr) * | 1982-12-28 | 1984-06-29 | Fabre Sa Pierre | Nouvel extrait de ruscus, son procede de preparation et son application en tant que principe actif veinotonique |
| GB8523776D0 (en) * | 1985-09-26 | 1985-10-30 | Scras | Catechol derivatives |
| US4824831A (en) * | 1987-12-21 | 1989-04-25 | E. R. Squibb & Sons, Inc. | 4,5-dihydro-1H-benzazepine-3-carboxylic acid esters which are useful as anti-hypertensive agents |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
| EP1140185B1 (en) | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| CA2356157C (en) | 1998-12-23 | 2008-04-01 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| DK1140184T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer |
| DK1140188T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af ileale galdesyretransporthæmmere og cholesterylestere tranferproteinhæmmere til cardiovaskulære indikationer |
| CZ20012345A3 (cs) | 1998-12-23 | 2001-12-12 | G. D. Searle Llc Corporate Patent Department | Kombinace inhibitorů transportu kyčelní ľlučové kyseliny a činidel pro sekvenci ľlučové kyseliny pro kardiovaskulární indikace |
| HUP0104793A2 (en) | 1998-12-23 | 2002-06-29 | Searle Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| CA2373464A1 (en) | 1999-05-18 | 2000-11-23 | Tomomi Ikemoto | Process for the preparation of 2,3-dihydrothiepine derivatives |
| US6794544B2 (en) | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| CA2464685A1 (en) | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
| AU2003207431A1 (en) | 2002-01-17 | 2003-09-02 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| PL2771003T3 (pl) | 2011-10-28 | 2017-10-31 | Lumena Pharmaceuticals Llc | Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby |
| CN111087305B (zh) * | 2019-12-13 | 2021-08-27 | 南京工业大学 | 一种β-氟烷基肉桂酸酯类化合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL301813A (es) * | 1962-12-14 | 1900-01-01 | ||
| US3374245A (en) | 1964-04-01 | 1968-03-19 | Ciba Geigy Corp | Unsaturated oxacycles |
| US3444176A (en) * | 1967-04-28 | 1969-05-13 | Mcneilab Inc | Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof |
-
1982
- 1982-05-05 AU AU83417/82A patent/AU548253B2/en not_active Ceased
- 1982-05-10 ES ES512045A patent/ES8303395A1/es not_active Expired
- 1982-05-10 CA CA000402572A patent/CA1196637A/fr not_active Expired
- 1982-05-10 EP EP82400862A patent/EP0067086B1/fr not_active Expired
- 1982-05-10 US US06/376,645 patent/US4436749A/en not_active Expired - Lifetime
- 1982-05-10 DE DE8282400862T patent/DE3267884D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU8341782A (en) | 1982-11-18 |
| DE3267884D1 (en) | 1986-01-23 |
| AU548253B2 (en) | 1985-12-05 |
| CA1196637A (fr) | 1985-11-12 |
| ES512045A0 (es) | 1983-03-01 |
| EP0067086B1 (fr) | 1985-12-11 |
| US4436749A (en) | 1984-03-13 |
| EP0067086A1 (fr) | 1982-12-15 |
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