DE3267884D1 - Benzoxepine derivatives and their sulfur and nitrogen analogues, their preparation and application as medicaments - Google Patents
Benzoxepine derivatives and their sulfur and nitrogen analogues, their preparation and application as medicamentsInfo
- Publication number
- DE3267884D1 DE3267884D1 DE8282400862T DE3267884T DE3267884D1 DE 3267884 D1 DE3267884 D1 DE 3267884D1 DE 8282400862 T DE8282400862 T DE 8282400862T DE 3267884 T DE3267884 T DE 3267884T DE 3267884 D1 DE3267884 D1 DE 3267884D1
- Authority
- DE
- Germany
- Prior art keywords
- medicaments
- sulfur
- preparation
- application
- nitrogen analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 150000005119 benzoxepines Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000002829 nitrogen Chemical class 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8109327 | 1981-05-11 | ||
FR8207693A FR2526429A1 (fr) | 1982-05-04 | 1982-05-04 | Nouveaux composes de la serie des benzoxepines et analogues soufres et azotes, leurs procedes de preparation et utilisations en tant que medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3267884D1 true DE3267884D1 (en) | 1986-01-23 |
Family
ID=26222386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8282400862T Expired DE3267884D1 (en) | 1981-05-11 | 1982-05-10 | Benzoxepine derivatives and their sulfur and nitrogen analogues, their preparation and application as medicaments |
Country Status (6)
Country | Link |
---|---|
US (1) | US4436749A (de) |
EP (1) | EP0067086B1 (de) |
AU (1) | AU548253B2 (de) |
CA (1) | CA1196637A (de) |
DE (1) | DE3267884D1 (de) |
ES (1) | ES8303395A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2538250A1 (fr) * | 1982-12-28 | 1984-06-29 | Fabre Sa Pierre | Nouvel extrait de ruscus, son procede de preparation et son application en tant que principe actif veinotonique |
GB8523776D0 (en) * | 1985-09-26 | 1985-10-30 | Scras | Catechol derivatives |
US4824831A (en) * | 1987-12-21 | 1989-04-25 | E. R. Squibb & Sons, Inc. | 4,5-dihydro-1H-benzazepine-3-carboxylic acid esters which are useful as anti-hypertensive agents |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
EP1140185B1 (de) | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen |
CA2356157C (en) | 1998-12-23 | 2008-04-01 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
DK1140184T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer |
DK1140188T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af ileale galdesyretransporthæmmere og cholesterylestere tranferproteinhæmmere til cardiovaskulære indikationer |
CZ20012345A3 (cs) | 1998-12-23 | 2001-12-12 | G. D. Searle Llc Corporate Patent Department | Kombinace inhibitorů transportu kyčelní ľlučové kyseliny a činidel pro sekvenci ľlučové kyseliny pro kardiovaskulární indikace |
HUP0104793A2 (en) | 1998-12-23 | 2002-06-29 | Searle Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
CA2373464A1 (en) | 1999-05-18 | 2000-11-23 | Tomomi Ikemoto | Process for the preparation of 2,3-dihydrothiepine derivatives |
US6794544B2 (en) | 2000-03-10 | 2004-09-21 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
CA2464685A1 (en) | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
AU2003207431A1 (en) | 2002-01-17 | 2003-09-02 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
PL2771003T3 (pl) | 2011-10-28 | 2017-10-31 | Lumena Pharmaceuticals Llc | Inhibitory ponownego wykorzystania kwasów żółciowych do leczenia pediatrycznych cholestatycznych chorób wątroby |
CN111087305B (zh) * | 2019-12-13 | 2021-08-27 | 南京工业大学 | 一种β-氟烷基肉桂酸酯类化合物及其制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL301813A (de) * | 1962-12-14 | 1900-01-01 | ||
US3374245A (en) | 1964-04-01 | 1968-03-19 | Ciba Geigy Corp | Unsaturated oxacycles |
US3444176A (en) * | 1967-04-28 | 1969-05-13 | Mcneilab Inc | Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof |
-
1982
- 1982-05-05 AU AU83417/82A patent/AU548253B2/en not_active Ceased
- 1982-05-10 ES ES512045A patent/ES8303395A1/es not_active Expired
- 1982-05-10 CA CA000402572A patent/CA1196637A/fr not_active Expired
- 1982-05-10 EP EP82400862A patent/EP0067086B1/de not_active Expired
- 1982-05-10 US US06/376,645 patent/US4436749A/en not_active Expired - Lifetime
- 1982-05-10 DE DE8282400862T patent/DE3267884D1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU8341782A (en) | 1982-11-18 |
AU548253B2 (en) | 1985-12-05 |
CA1196637A (fr) | 1985-11-12 |
ES512045A0 (es) | 1983-03-01 |
EP0067086B1 (de) | 1985-12-11 |
US4436749A (en) | 1984-03-13 |
EP0067086A1 (de) | 1982-12-15 |
ES8303395A1 (es) | 1983-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PIERRE FABRE S.A., BOULOGNE, FR |
|
8328 | Change in the person/name/address of the agent |
Free format text: GRUENECKER, KINKELDEY, STOCKMAIR & SCHWANHAEUSSER, ANWALTSSOZIETAET, 80538 MUENCHEN |
|
8339 | Ceased/non-payment of the annual fee |