KR840004685A - 티아졸 유도체의 제조방법 - Google Patents

티아졸 유도체의 제조방법

Info

Publication number
KR840004685A
KR840004685A KR1019830001578A KR830001578A KR840004685A KR 840004685 A KR840004685 A KR 840004685A KR 1019830001578 A KR1019830001578 A KR 1019830001578A KR 830001578 A KR830001578 A KR 830001578A KR 840004685 A KR840004685 A KR 840004685A
Authority
KR
South Korea
Prior art keywords
production
thiazole derivatives
thiazole
derivatives
Prior art date
Application number
KR1019830001578A
Other languages
English (en)
Other versions
KR840001075B1 (ko
Inventor
안토오니오 알제리 알도
레이 크렌쇼우 로니
Original Assignee
브리스톨-마이어스 컴페니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브리스톨-마이어스 컴페니 filed Critical 브리스톨-마이어스 컴페니
Application granted granted Critical
Publication of KR840001075B1 publication Critical patent/KR840001075B1/ko
Publication of KR840004685A publication Critical patent/KR840004685A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1019830001578A 1978-12-18 1983-04-14 티아졸 유도체의 제조방법 KR840001075B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US970,517 1978-12-18
US05/970,517 US4200578A (en) 1978-12-18 1978-12-18 Thiazole derivatives
KR7904488A KR830001920B1 (ko) 1978-12-18 1979-12-18 티아졸 유도체의 제조방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR7904488A Division KR830001920B1 (ko) 1978-12-18 1979-12-18 티아졸 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR840001075B1 KR840001075B1 (ko) 1984-07-31
KR840004685A true KR840004685A (ko) 1984-10-22

Family

ID=25517073

Family Applications (3)

Application Number Title Priority Date Filing Date
KR7904488A KR830001920B1 (ko) 1978-12-18 1979-12-18 티아졸 유도체의 제조방법
KR1019830001578A KR840001075B1 (ko) 1978-12-18 1983-04-14 티아졸 유도체의 제조방법
KR1019830001579A KR840001074B1 (ko) 1978-12-18 1983-04-14 티아줄 유도체의 제조방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR7904488A KR830001920B1 (ko) 1978-12-18 1979-12-18 티아졸 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019830001579A KR840001074B1 (ko) 1978-12-18 1983-04-14 티아줄 유도체의 제조방법

Country Status (24)

Country Link
US (1) US4200578A (ko)
JP (1) JPS5583768A (ko)
KR (3) KR830001920B1 (ko)
AT (1) AT375354B (ko)
AU (1) AU533014B2 (ko)
BE (1) BE880662A (ko)
CA (1) CA1133909A (ko)
CH (1) CH642956A5 (ko)
DE (1) DE2950838A1 (ko)
DK (1) DK533979A (ko)
ES (2) ES487035A0 (ko)
FI (1) FI793904A (ko)
FR (1) FR2444674B1 (ko)
GB (1) GB2038822B (ko)
GR (1) GR73586B (ko)
HU (1) HU182461B (ko)
IE (1) IE49320B1 (ko)
IL (1) IL58960A (ko)
IT (1) IT1164076B (ko)
LU (1) LU82000A1 (ko)
NL (1) NL7909054A (ko)
SE (1) SE444680B (ko)
YU (3) YU292179A (ko)
ZA (1) ZA796814B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
GR71929B (ko) * 1979-11-13 1983-08-19 Ici Ltd
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
FI840474A (fi) * 1983-02-07 1984-08-08 Lilly Co Eli Foerbaettringar vid syntes av nizatidin samt foerbaettringar beroerande denna.
CA1277325C (en) * 1985-12-18 1990-12-04 Bruce A. Slomski Synthesis of nizatidine
JPH0247453U (ko) * 1988-09-29 1990-03-30
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer
CN111974333B (zh) * 2020-08-19 2023-06-09 宁夏亚东化工有限公司 噻唑生产线及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4072748A (en) * 1972-09-05 1978-02-07 Smith Kline & French Laboratories Limited Certain guanidine compounds, and their use as inhibitors of histamine activity
BE804144A (en) 1972-09-05 1974-02-28 Smith Kline French Lab H-2-Receptor antihistamines esp gastric acid inhibitors - -N-cyano-N"-(heterocyclyl-alkyl-(thio oxa amino or methylene-alkyl)-guanidines
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1553070A (en) 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
IE47044B1 (en) 1977-04-20 1983-12-14 Ici Ltd Guanidine derivatives
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Also Published As

Publication number Publication date
CH642956A5 (fr) 1984-05-15
IT1164076B (it) 1987-04-08
FR2444674A1 (fr) 1980-07-18
IE792436L (en) 1980-06-18
ES8101569A1 (es) 1980-12-16
NL7909054A (nl) 1980-06-20
US4200578A (en) 1980-04-29
GB2038822A (en) 1980-07-30
KR830001920B1 (ko) 1983-09-23
AU533014B2 (en) 1983-10-27
BE880662A (fr) 1980-06-17
KR830001263A (ko) 1983-04-29
IL58960A (en) 1983-06-15
ES487035A0 (es) 1980-12-16
KR840001074B1 (ko) 1984-07-31
JPS5583768A (en) 1980-06-24
AU5371679A (en) 1980-06-26
ES493718A0 (es) 1981-09-01
CA1133909A (en) 1982-10-19
AT375354B (de) 1984-07-25
KR840001075B1 (ko) 1984-07-31
DK533979A (da) 1980-06-19
YU259382A (en) 1983-02-28
IL58960A0 (en) 1980-03-31
YU259482A (en) 1983-02-28
YU292179A (en) 1983-02-28
ATA793779A (de) 1983-12-15
HU182461B (en) 1984-01-30
FI793904A (fi) 1980-06-19
LU82000A1 (de) 1980-07-21
FR2444674B1 (fr) 1986-03-28
IT7950977A0 (it) 1979-12-04
ES8106715A1 (es) 1981-09-01
IE49320B1 (en) 1985-09-18
ZA796814B (en) 1980-11-26
DE2950838A1 (de) 1980-07-03
KR840004686A (ko) 1984-10-22
SE444680B (sv) 1986-04-28
GR73586B (ko) 1984-03-26
SE7910392L (sv) 1980-06-19
GB2038822B (en) 1983-01-19
JPS639512B2 (ko) 1988-02-29

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Legal Events

Date Code Title Description
A107 Divisional application of patent
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee