DE602005005456D1 - Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number
DE602005005456D1
DE602005005456D1 DE602005005456T DE602005005456T DE602005005456D1 DE 602005005456 D1 DE602005005456 D1 DE 602005005456D1 DE 602005005456 T DE602005005456 T DE 602005005456T DE 602005005456 T DE602005005456 T DE 602005005456T DE 602005005456 D1 DE602005005456 D1 DE 602005005456D1
Authority
DE
Germany
Prior art keywords
azabic
derivatives
manufacturing
new
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005005456T
Other languages
English (en)
Other versions
DE602005005456T2 (de
Inventor
Patrick Casara
Anne-Marie Chollet
Alain Dhainaut
Lionel Bert
Pierre Lestage
Brian Lockhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of DE602005005456D1 publication Critical patent/DE602005005456D1/de
Application granted granted Critical
Publication of DE602005005456T2 publication Critical patent/DE602005005456T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DE602005005456T 2004-02-20 2005-02-18 Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen Active DE602005005456T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0401690A FR2866647B1 (fr) 2004-02-20 2004-02-20 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0401690 2004-02-20
PCT/FR2005/000382 WO2005089747A1 (fr) 2004-02-20 2005-02-18 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE602005005456D1 true DE602005005456D1 (de) 2008-04-30
DE602005005456T2 DE602005005456T2 (de) 2009-04-09

Family

ID=34833930

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005005456T Active DE602005005456T2 (de) 2004-02-20 2005-02-18 Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen

Country Status (30)

Country Link
US (1) US7576120B2 (de)
EP (1) EP1720544B1 (de)
JP (1) JP4519861B2 (de)
KR (1) KR100885104B1 (de)
CN (2) CN100577160C (de)
AR (3) AR047685A1 (de)
AT (1) ATE389398T1 (de)
AU (1) AU2005224129B2 (de)
BR (1) BRPI0507830A (de)
CA (1) CA2555216C (de)
CY (1) CY1108529T1 (de)
DE (1) DE602005005456T2 (de)
DK (1) DK1720544T3 (de)
EA (1) EA010300B1 (de)
ES (1) ES2303233T3 (de)
FR (1) FR2866647B1 (de)
GE (1) GEP20094578B (de)
HK (1) HK1123789A1 (de)
HR (1) HRP20080184T5 (de)
MA (1) MA28342A1 (de)
ME (1) ME01400B (de)
MY (1) MY137282A (de)
NO (1) NO337013B1 (de)
NZ (1) NZ548898A (de)
PL (1) PL1720544T3 (de)
PT (1) PT1720544E (de)
RS (1) RS50577B (de)
SI (1) SI1720544T1 (de)
WO (1) WO2005089747A1 (de)
ZA (1) ZA200606558B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1717234A1 (de) * 2005-04-29 2006-11-02 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
EP1717235A3 (de) * 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
TW200900072A (en) * 2007-03-22 2009-01-01 Arete Therapeutics Inc Soluble epoxide hydrolase inhibitors
FR2932479A1 (fr) 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2937251B1 (fr) * 2008-10-16 2011-03-18 Servier Lab Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil
FR2953514B1 (fr) * 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-3-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953521B1 (fr) * 2009-12-09 2011-11-18 Servier Lab Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953513B1 (fr) * 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-6-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953515B1 (fr) 2009-12-09 2011-12-23 Servier Lab Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2974729B1 (fr) 2011-05-02 2013-04-19 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR2976285B1 (fr) 2011-06-08 2013-05-24 Servier Lab Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
FR2976286B1 (fr) 2011-06-08 2013-05-24 Servier Lab 4-{3-[trans-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, son procede de preparation et les compositions pharmaceutiques qui le contiennent
WO2013085018A1 (ja) 2011-12-08 2013-06-13 大正製薬株式会社 フェニルピロール誘導体
FR2983732B1 (fr) 2011-12-09 2013-11-22 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent
US20150045553A1 (en) * 2011-12-27 2015-02-12 Taisho Pharmaceutical Co., Ltd Phenyltriazole derivative
CN103183632A (zh) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 一种3-氮杂双环辛烷盐酸盐的提纯方法
FR2999179A1 (fr) 2012-12-07 2014-06-13 Servier Lab Procede de synthese d'un sel d'addition a un acide pharmaceutiquement acceptable du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, ainsi que les formes cristallines associees
FR3003466B1 (fr) * 2013-03-22 2015-08-07 Servier Lab Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques
EP3594206A1 (de) * 2018-07-09 2020-01-15 Abivax Phenyl-n-chinolin-derivate zur behandlung einer rna-virusinfektion
EP3594205A1 (de) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl-derivate zur behandlung einer rna-virusinfektion
CN111377846B (zh) * 2018-12-27 2022-05-24 江苏恩华药业股份有限公司 一种哌嗪苯甲酰胺类衍生物及其应用
CN111377911B (zh) * 2018-12-27 2022-05-24 江苏恩华药业股份有限公司 一种吗啉苯甲酰胺类化合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2962496A (en) * 1957-01-28 1960-11-29 Geschickter Fund Med Res Nu-substituted-3-azabicyclooctanes [3: 3: 0] and salts thereof
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
CA2410972A1 (en) * 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
PT1301480E (pt) * 2000-07-13 2007-11-29 Abbott Lab Pirrolidinas 1,3-di-substituídas e 1,3,3-tri-substituídas úteis como ligandos do receptor de histamina-3 e suas aplicações terapêuticas
FR2827288B1 (fr) * 2001-07-12 2003-10-31 Servier Lab Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
WO2005089747A1 (fr) 2005-09-29
EA010300B1 (ru) 2008-08-29
MA28342A1 (fr) 2006-12-01
HRP20080184T5 (en) 2008-10-31
KR20060114382A (ko) 2006-11-06
KR100885104B1 (ko) 2009-02-20
JP4519861B2 (ja) 2010-08-04
CN101230033A (zh) 2008-07-30
CN1921848A (zh) 2007-02-28
CY1108529T1 (el) 2014-04-09
ES2303233T3 (es) 2008-08-01
AR094601A2 (es) 2015-08-12
DK1720544T3 (da) 2008-07-21
HRP20080184T3 (en) 2008-05-31
US7576120B2 (en) 2009-08-18
PT1720544E (pt) 2008-05-08
AU2005224129B2 (en) 2010-08-12
ME01400B (en) 2013-12-20
BRPI0507830A (pt) 2007-07-10
AR047685A1 (es) 2006-02-01
AR089451A2 (es) 2014-08-27
NO20064160L (no) 2006-09-14
JP2007523135A (ja) 2007-08-16
ATE389398T1 (de) 2008-04-15
EA200601512A1 (ru) 2007-02-27
ZA200606558B (en) 2008-01-08
MY137282A (en) 2009-01-30
AU2005224129A1 (en) 2005-09-29
CN101230033B (zh) 2011-03-09
EP1720544B1 (de) 2008-03-19
GEP20094578B (en) 2009-01-12
CA2555216C (fr) 2011-10-11
CA2555216A1 (fr) 2005-09-29
NZ548898A (en) 2010-06-25
US20070197625A1 (en) 2007-08-23
HK1123789A1 (en) 2009-06-26
FR2866647A1 (fr) 2005-08-26
DE602005005456T2 (de) 2009-04-09
EP1720544A1 (de) 2006-11-15
NO337013B1 (no) 2015-12-21
SI1720544T1 (sl) 2008-06-30
CN100577160C (zh) 2010-01-06
RS50577B (sr) 2010-05-07
PL1720544T3 (pl) 2008-05-30
FR2866647B1 (fr) 2006-10-27

Similar Documents

Publication Publication Date Title
DE602005005456D1 (de) Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen
IL177168A0 (en) N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same
BRPI0508263B8 (pt) derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina
EP1841761A4 (de) Fumagillolderivate oder verfahren zur herstellung von fumagillolderivaten, und pharmazeutische zusammensetzungen, die diese enthalten
IL187224A0 (en) Bicyclic derivatives and pharmaceutical compositions containing the same
IL183583A0 (en) Quinazoline derivatives and pharmaceutical compositions containing the same
BRPI0607198A2 (pt) composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica
IL216734A0 (en) Azaindole derivatives and pharmaceutical compositions containing the same
IL181524A (en) Heterocyclic compounds, pharmaceuticals containing them and their use in the preparation of drugs
IL178414A0 (en) Azaindole derivatives and pharmaceutical compositions containing the same
IL188941A0 (en) Pyrazinolyguanidine derivatives and pharmaceutical compositions containing the same
IL192184A0 (en) Heterocyclic derivatives and pharmaceutical compositions containing the same
IL221323A0 (en) 1-methyl-1h- pyridin-2-one- phenanthridine derivatives and pharmaceutical compositions containing the same
IL186738A0 (en) Pyrizole derivatives and pharmaceutical compositions containing the same
IL185353A0 (en) Azabicycloalkane derivatives , pharmaceutical compositions containing the same and methods for the preparation thereof
IL183919A0 (en) Triazolophthalazine derivatives and pharmaceutical compositions containing the same
IL189782A0 (en) Sulphonylpyrrole derivatives and pharmaceutical compositions containing the same
ATE538125T1 (de) Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren
ITMI20031570A1 (it) Composizione per uso dietetico, farmaceutico o cosmetico
DK1587478T3 (da) Farmaceutisk sammensætning
IL184996A0 (en) Dihydroimidazothiazole derivatives and pharmaceutical compositions containing the same
IL180303A0 (en) Azaindole derivatives and pharmaceutical compositions containing the same
EP1845099A4 (de) Artemisin- (qinghaosu-) derivate, verfahren zu deren herstellung und deren verwendung, und diese enthaltende pharmazeutische zusammensetzungen
IL181730A0 (en) Benzodiazinone derivatives and pharmaceutical compositions containing the same
IL177498A0 (en) Difluoroethoxy -substituted hydroxy-6-phenylphenanthridine derivatives and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
8364 No opposition during term of opposition