EP1845099A4 - Artemisin- (qinghaosu-) derivate, verfahren zu deren herstellung und deren verwendung, und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Artemisin- (qinghaosu-) derivate, verfahren zu deren herstellung und deren verwendung, und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
EP1845099A4
EP1845099A4 EP06705603A EP06705603A EP1845099A4 EP 1845099 A4 EP1845099 A4 EP 1845099A4 EP 06705603 A EP06705603 A EP 06705603A EP 06705603 A EP06705603 A EP 06705603A EP 1845099 A4 EP1845099 A4 EP 1845099A4
Authority
EP
European Patent Office
Prior art keywords
artemisine
qinghaosu
derivatives
pharmaceutical compositions
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06705603A
Other languages
English (en)
French (fr)
Other versions
EP1845099A1 (de
EP1845099B1 (de
Inventor
Ying Li
Jianping Zuo
Zhongshun Yang
Wenliang Zhou
Yi Sui
Junxia Wang
Yu Zhang
Yu Zhou
Jinming Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Materia Medica of CAS
Original Assignee
Shanghai Institute of Materia Medica of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute of Materia Medica of CAS filed Critical Shanghai Institute of Materia Medica of CAS
Publication of EP1845099A1 publication Critical patent/EP1845099A1/de
Publication of EP1845099A4 publication Critical patent/EP1845099A4/de
Application granted granted Critical
Publication of EP1845099B1 publication Critical patent/EP1845099B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP06705603A 2005-02-04 2006-01-27 Artemisin- (qinghaosu-) derivate, verfahren zu deren herstellung und deren verwendung, und diese enthaltende pharmazeutische zusammensetzungen Active EP1845099B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2005100238241A CN1814601A (zh) 2005-02-04 2005-02-04 具有免疫抑制作用的青蒿素衍生物及药物组合物
PCT/CN2006/000182 WO2006081771A1 (fr) 2005-02-04 2006-01-27 Dérivés d'artémisine (qinghaosu), méthodes de synthèse et applications, et préparations pharmaceutiques contenant lesdits dérivés

Publications (3)

Publication Number Publication Date
EP1845099A1 EP1845099A1 (de) 2007-10-17
EP1845099A4 true EP1845099A4 (de) 2010-10-06
EP1845099B1 EP1845099B1 (de) 2012-10-24

Family

ID=36776974

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06705603A Active EP1845099B1 (de) 2005-02-04 2006-01-27 Artemisin- (qinghaosu-) derivate, verfahren zu deren herstellung und deren verwendung, und diese enthaltende pharmazeutische zusammensetzungen

Country Status (5)

Country Link
US (1) US7910750B2 (de)
EP (1) EP1845099B1 (de)
JP (1) JP4891926B2 (de)
CN (2) CN1814601A (de)
WO (1) WO2006081771A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102010420B (zh) * 2010-10-12 2013-11-27 沈阳药科大学 [(10s)-9，10-二氢青蒿素-10-氧基]苯甲醛缩氨基(硫)脲系列物及其制备方法和用途
EP3269371A1 (de) 2011-06-10 2018-01-17 Queen Mary University of London Artemisinin und dessen derivate zur behandlung von myokardininfarkten oder der koronaren kerzkrankheit
WO2013130725A1 (en) * 2012-02-28 2013-09-06 The Johns Hopkins University Trioxane thioacetal monomers and dimers and methods of use thereof
CN102603768A (zh) * 2012-03-07 2012-07-25 广州牌牌生物科技有限公司 一种使用大孔树脂分离纯化青蒿素的方法
US9663532B2 (en) 2012-10-29 2017-05-30 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
EP2931283B1 (de) 2012-12-12 2020-04-08 Queen Mary and Westfield College University of London Artemisinin und dessen derivate zur verwendung bei der behandlung von nierenerkrankungen
US20170326102A1 (en) * 2014-11-27 2017-11-16 Cipla Limited Pharmaceutical Composition Comprising an Artemisinin Derivative for Nasal or Pulmonary Delivery
CN108653272B (zh) * 2017-03-31 2022-09-20 中国科学院上海药物研究所 青蒿素类衍生物在制备用于治疗炎症性肠病的药物中的用途
WO2021186396A2 (en) * 2020-03-18 2021-09-23 Oncotelic Inc. Tgf-beta inhibition, agents and composition therefor
CN115068478B (zh) * 2022-07-22 2024-01-09 上海医药工业有限公司 磷酸萘酚喹在制备治疗自身免疫性疾病药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390840A (zh) * 2001-06-08 2003-01-15 中国科学院上海药物研究所 青蒿素芳香醚类衍生物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791135A (en) 1987-08-20 1988-12-13 The United States Of America As Represented By The Secretary Of The Army Novel antimalarial dihydroartemisinin derivatives
CN1038416C (zh) * 1992-12-04 1998-05-20 中国科学院上海药物研究所 新型青蒿素衍生物及其制备方法
CN1049435C (zh) * 1994-11-09 2000-02-16 中国科学院上海药物研究所 含苯基和杂环基的青蒿素衍生物及其制备方法
EP1040836A4 (de) * 1997-12-24 2004-11-10 Fujisawa Pharmaceutical Co Immunsuppressive agonisten
CN1109035C (zh) * 1998-04-08 2003-05-21 中国科学院上海药物研究所 12位芳基取代的青蒿素衍生物、制备方法及其应用
CN1084333C (zh) 1998-06-17 2002-05-08 中国科学院上海药物研究所 新的青蒿素化合物,其制备方法以及含有它们的药物组合物
IN191696B (de) * 1999-02-12 2003-12-20 Council Scient Ind Res
EP1465899A1 (de) * 2001-12-06 2004-10-13 Ufc Limited Trioxan derivate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390840A (zh) * 2001-06-08 2003-01-15 中国科学院上海药物研究所 青蒿素芳香醚类衍生物及其制备方法

Also Published As

Publication number Publication date
JP4891926B2 (ja) 2012-03-07
EP1845099A1 (de) 2007-10-17
US7910750B2 (en) 2011-03-22
WO2006081771A1 (fr) 2006-08-10
CN101103036A (zh) 2008-01-09
US20080139642A1 (en) 2008-06-12
CN1814601A (zh) 2006-08-09
EP1845099B1 (de) 2012-10-24
CN101103036B (zh) 2010-05-19
JP2008528641A (ja) 2008-07-31

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