AR046941A1 - Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico - Google Patents

Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico

Info

Publication number
AR046941A1
AR046941A1 ARP040104663A ARP040104663A AR046941A1 AR 046941 A1 AR046941 A1 AR 046941A1 AR P040104663 A ARP040104663 A AR P040104663A AR P040104663 A ARP040104663 A AR P040104663A AR 046941 A1 AR046941 A1 AR 046941A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
hydrogen
hydroxy
halogen
Prior art date
Application number
ARP040104663A
Other languages
English (en)
Inventor
Wilm Buhr
Peter Jan Zimmermann
Christof Brehm
Andreas Palmer
M Vittoria Chiesa
Wolfgang-Alexander Simon
Stefan Postius
Wolfgang Kromer
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of AR046941A1 publication Critical patent/AR046941A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicacion 1: Un compuesto de la formula (1), en la cual: R1 es hidrogeno, alquilo (C1-4), cicloalquilo (C3-7), alcoxi(C1-4)-alquilo(C1-4), o alcoxi(C1-4)-carbonilo; R2 es hidrogeno, alquilo (C1-4), halogeno, alquenilo (C2-4), alquinilo (C2-4), hidroxi-alquilo(C1-4), cicloalquilo (C3-7), alcoxi(C1-4)-carbonilo; R3 es hidroxi-alquilo(C1-2), alcoxi-(C1-4)alquilo(C1-2), alcoxi(C1-4)-alcoxi(C1-4)-alquilo(C1-2), alcoxi(C1-4)-carbonilo o el radical -CO-NR31R32; en donde R31 es hidrogeno, alquilo (C1-7), hidroxi-alquilo(C1-4) o alcoxi(C1-4)-alquilo(C1-4); y R32 es hidrogeno, alquilo (C1-7), hidroxi-alquilo(C1-4) o alcoxi(C1-4)-alquilo(C1-4), o en donde R31 y R32 juntos e incluyendo el átomo de nitrogeno al cual están unidos son un radical pirrolidino, piperidino, morfolino; Arom es un radical aromático mono- o bicíclico sustituido con R4, R5, R6 y R7 seleccionado del grupo que consiste de fenilo, naftilo, pirrolilo, pirazolilo, imidazolilo, 1,2,3-triazolilo, indolilo, bencimidazolilo, furanilo (furilo), benzofuranilo (benzofurilo), tiofenilo (tienilo), benzotiofenilo, (benzotienilo), tiazolilo, isoxazolilo, piridinilo, pirimidinilo, quinolinilo e isoquinolinilo, en donde R4 es hidrogeno, alquilo (C1-4), hidroxi- alquilo(C1-4), alcoxi (C1-4), carboxilo, alcoxi(C1-4)-carbonilo, carboxi-alquilo(C1-4), alcoxi(C1-4)-carbonilo-alquilo(C1-4), halogeno, hidroxilo, arilo, aril-alquilo(C1-4), ariloxi, aril-alcoxi(C1-4), trifluorometilo, nitro, amino, mono- o di- alquil(C1-4)-amino, alquil(C1-4)-carbonilamino, alcoxi(C1-4)-carbonilamino, alcoxi(C1-4)-alcoxi(C1-4)-carbonilamino o sulfonilo; R5 es hidrogeno, alquilo (C1-4), alcoxi (C1-4), alcoxi(C1-4)-carbonilo, halogeno, trifluorometilo o hidroxilo; R6 es hidrogeno, alquilo (C1-4) o halogeno; y R7 es hidrogeno, alquilo (C1-4) o halogeno, en donde arilo es fenilo o fenilo sustituido que tiene uno, dos o tres sustituyentes idénticos o diferentes del grupo que consiste de alquilo (C1-4), alcoxi (C1-4), carboxilo, alcoxi(C1-4)-carbonilo, halogeno, trifluorometilo, nitro, trifluorometoxi, hidroxilo y ciano; y sus sales.
ARP040104663A 2003-12-19 2004-12-15 Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico AR046941A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03029361 2003-12-19

Publications (1)

Publication Number Publication Date
AR046941A1 true AR046941A1 (es) 2006-01-04

Family

ID=34684549

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104663A AR046941A1 (es) 2003-12-19 2004-12-15 Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico

Country Status (15)

Country Link
US (1) US20070066674A1 (es)
EP (1) EP1696921A1 (es)
JP (1) JP2007514714A (es)
KR (1) KR20070007041A (es)
CN (1) CN1889955A (es)
AR (1) AR046941A1 (es)
AU (1) AU2004298788A1 (es)
BR (1) BRPI0417263A (es)
CA (1) CA2549030A1 (es)
EA (1) EA200601106A1 (es)
IL (1) IL175724A0 (es)
NO (1) NO20063220L (es)
TW (1) TW200526212A (es)
WO (1) WO2005058325A1 (es)
ZA (1) ZA200604134B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005058894A1 (en) 2003-12-19 2005-06-30 Altana Pharma Ag Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives
EA200702587A1 (ru) * 2005-06-22 2008-06-30 Никомед Гмбх Способ синтеза промежуточных продуктов, предназначенных для получения трициклических бензимидазолов
WO2007141253A1 (en) * 2006-06-07 2007-12-13 Nycomed Gmbh Process for the production of intermediates for the preparation of tricyclic imidazopyridines
JP5802898B2 (ja) 2009-07-09 2015-11-04 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
EP3004094B1 (de) 2013-06-04 2017-03-01 Bayer Pharma Aktiengesellschaft 3-aryl-substituierte imidazo[1,2-a]pyridine und ihre verwendung
JP2017507140A (ja) 2014-02-19 2017-03-16 バイエル・ファルマ・アクティエンゲゼルシャフト ３−（ピリミジン−２−イル）イミダゾ［１，２−ａ］ピリジン
CA2969268A1 (en) 2014-12-02 2016-06-09 Bayer Pharma Aktiengesellschaft Heteroaryl-substituted imidazo[1,2-a]pyridines and their use
CN112500421B (zh) * 2020-12-15 2021-08-24 河南科技大学第一附属医院 一种可用于杀菌消毒的苯并吡喃脲类化合物的制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468400A (en) * 1982-12-20 1984-08-28 Schering Corporation Antiulcer tricyclic imidazo [1,2-a]pyridines
CA2426616A1 (en) * 2000-10-25 2002-05-02 Altana Pharma Ag Polysubstituted imidazopyridines as gastric secretion inhibitors
PL368195A1 (en) * 2001-08-10 2005-03-21 Altana Pharma Ag Tricyclic imidazopyridines

Also Published As

Publication number Publication date
JP2007514714A (ja) 2007-06-07
WO2005058325A1 (en) 2005-06-30
CN1889955A (zh) 2007-01-03
BRPI0417263A (pt) 2007-03-06
NO20063220L (no) 2006-07-11
TW200526212A (en) 2005-08-16
IL175724A0 (en) 2006-09-05
AU2004298788A1 (en) 2005-06-30
WO2005058325A8 (en) 2006-05-11
ZA200604134B (en) 2008-01-30
EA200601106A1 (ru) 2006-12-29
CA2549030A1 (en) 2005-06-30
US20070066674A1 (en) 2007-03-22
EP1696921A1 (en) 2006-09-06
KR20070007041A (ko) 2007-01-12

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