EA201170176A1 - Ингибитор stat3, содержащий хинолинкарбоксамидное производное в качестве активного ингредиента - Google Patents

Ингибитор stat3, содержащий хинолинкарбоксамидное производное в качестве активного ингредиента

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Publication number
EA201170176A1
EA201170176A1 EA201170176A EA201170176A EA201170176A1 EA 201170176 A1 EA201170176 A1 EA 201170176A1 EA 201170176 A EA201170176 A EA 201170176A EA 201170176 A EA201170176 A EA 201170176A EA 201170176 A1 EA201170176 A1 EA 201170176A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active ingredient
quinolinkarboxamide
derivative
stat3 inhibitor
formula
Prior art date
Application number
EA201170176A
Other languages
English (en)
Other versions
EA021306B1 (ru
Inventor
Акира Асаи
Кендзи Мацуно
Наохиса Ого
Такане Йокотагава
Осаму Такахаси
Ясуто Акияма
Тадаси Асизава
Тадаси Окавара
Original Assignee
ФАРМА АйПи ДЖЕНЕРАЛ ИНКОРПОРЕЙТЕД АССОШИЭЙШН
Фарма Дизайн, Инк.
Сизуока Префекче
Кумамото Хелт Сайенс Юниверсити
Кабусики Кайся Якулт Хонса
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ФАРМА АйПи ДЖЕНЕРАЛ ИНКОРПОРЕЙТЕД АССОШИЭЙШН, Фарма Дизайн, Инк., Сизуока Префекче, Кумамото Хелт Сайенс Юниверсити, Кабусики Кайся Якулт Хонса filed Critical ФАРМА АйПи ДЖЕНЕРАЛ ИНКОРПОРЕЙТЕД АССОШИЭЙШН
Publication of EA201170176A1 publication Critical patent/EA201170176A1/ru
Publication of EA021306B1 publication Critical patent/EA021306B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение предоставляет ингибитор STAT3, содержащий в качестве активного ингредиента хинолинкарбоксамидное производное, представленное формулой (I) (в формуле W представляет собой связь или алкиленовую связь; Х представляет собой О, S или NR; и от Rдо Rи Rкаждый представляет собой Н, галоген, алкил, фенил, фурил, тиенил или подобное), или его фармакологически приемлемую соль.
EA201170176A 2008-07-10 2009-07-10 Ингибитор stat3, содержащий хинолинкарбоксамидное производное в качестве активного ингредиента EA021306B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008180433 2008-07-10
PCT/JP2009/003235 WO2010004761A1 (ja) 2008-07-10 2009-07-10 キノリンカルボキサミド誘導体を有効成分とするｓｔａｔ３阻害剤

Publications (2)

Publication Number Publication Date
EA201170176A1 true EA201170176A1 (ru) 2011-08-30
EA021306B1 EA021306B1 (ru) 2015-05-29

Family

ID=41506885

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170176A EA021306B1 (ru) 2008-07-10 2009-07-10 Ингибитор stat3, содержащий хинолинкарбоксамидное производное в качестве активного ингредиента

Country Status (12)

Country Link
US (1) US8466290B2 (ru)
EP (1) EP2325181B1 (ru)
JP (1) JP5650529B2 (ru)
KR (1) KR101696936B1 (ru)
CN (1) CN102099352B (ru)
AU (1) AU2009269410B2 (ru)
CA (1) CA2729988C (ru)
EA (1) EA021306B1 (ru)
ES (1) ES2622575T3 (ru)
NZ (2) NZ602099A (ru)
PL (1) PL2325181T3 (ru)
WO (1) WO2010004761A1 (ru)

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TWI523851B (zh) 2009-12-28 2016-03-01 Yakult Honsha Kk 1,3,4-oxadiazole-2-carboxamide
BR112013007907A2 (pt) * 2010-10-08 2016-06-14 N30 Pharmaceuticals Inc novos compostos de quinolina substituída como inibidores de s-nitrosoglutationa reductase
EP2635280A4 (en) * 2010-11-05 2014-05-28 Univ Minnesota MODULATORS OF CYTOSINE DEAMINASE FOR ENHANCED DNA TRANSFECTION
JPWO2012121168A1 (ja) * 2011-03-04 2014-07-17 国立大学法人京都大学 キナーゼ阻害剤
CN102827142B (zh) * 2011-06-17 2014-11-12 中国科学院上海药物研究所 一类喹啉-8-甲酰胺类化合物、其制备方法及其医药用途
CN102417479B (zh) * 2011-08-29 2014-02-26 南京大学 Stat3小分子选择性抑制剂及其制备方法和应用
BR112014029439A2 (pt) * 2012-05-25 2017-06-27 Governing Council Univ Toronto derivados de ácido salicílico, sal farmaceuticamente aceitável dos mesmos, composição dos mesmos e método de uso dos mesmos
US8791067B2 (en) 2012-07-24 2014-07-29 Morehouse School Of Medicine Method for treating malaria
CN103910727B (zh) * 2012-12-31 2016-06-15 北京大学 STAT3-Hif1α信号通路抑制剂及其在抗肿瘤中的应用
US10562912B2 (en) * 2013-06-05 2020-02-18 C&C Research Laboratories Heterocyclic derivatives and use thereof
WO2015106272A1 (en) * 2014-01-13 2015-07-16 Harki Daniel A Small molecule inhibitors of apobec3g and apobec3b
US11406707B2 (en) 2014-02-10 2022-08-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. STAT3 phosphorylation during graft-versus-host disease
KR20160066490A (ko) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
WO2016202935A1 (en) * 2015-06-19 2016-12-22 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
EP3515449B1 (en) * 2016-09-26 2023-07-12 Dana-Farber Cancer Institute, Inc. Quinoline derivatives as chromobox (cbx) protein inhibitors for treating cancer
TW202016076A (zh) 2018-05-31 2020-05-01 南韓商Ｃ＆Ｃ新藥研究所 雜環衍生物及其用途
CA3113408A1 (en) * 2018-09-18 2020-03-26 Kabushiki Kaisha Yakult Honsha Cancer combination therapy using quinoline carboxamide derivative
EP3943159A4 (en) * 2019-03-22 2023-04-05 Kabushiki Kaisha Yakult Honsha METHOD FOR THE PRODUCTION OF A QUINOLINECARBOXAMIDE DERIVATIVE OR AN INTERMEDIATE THEREOF
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US20220218693A1 (en) * 2019-04-26 2022-07-14 Kabushiki Kaisha Yakult Honsha Immune checkpoint inhibitor combination therapy using quinoline carboxamide derivative

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TWI335913B (en) 2002-11-15 2011-01-11 Vertex Pharma Diaminotriazoles useful as inhibitors of protein kinases
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Also Published As

Publication number Publication date
AU2009269410A1 (en) 2010-01-14
CN102099352A (zh) 2011-06-15
ES2622575T3 (es) 2017-07-06
EP2325181B1 (en) 2017-03-29
NZ602099A (en) 2014-06-27
CA2729988A1 (en) 2010-01-14
JPWO2010004761A1 (ja) 2011-12-22
US8466290B2 (en) 2013-06-18
AU2009269410B2 (en) 2013-12-05
PL2325181T3 (pl) 2017-09-29
EA021306B1 (ru) 2015-05-29
KR101696936B1 (ko) 2017-01-16
NZ590355A (en) 2013-01-25
US20110172429A1 (en) 2011-07-14
CN102099352B (zh) 2014-02-26
EP2325181A1 (en) 2011-05-25
JP5650529B2 (ja) 2015-01-07
WO2010004761A1 (ja) 2010-01-14
KR20110039221A (ko) 2011-04-15
CA2729988C (en) 2016-09-13
EP2325181A4 (en) 2012-03-07

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