PL2325181T3 - Inhibitor STAT3 zawierający jako składnik aktywny pochodną chinolinokarboksyamidu - Google Patents
Inhibitor STAT3 zawierający jako składnik aktywny pochodną chinolinokarboksyamiduInfo
- Publication number
- PL2325181T3 PL2325181T3 PL09794208T PL09794208T PL2325181T3 PL 2325181 T3 PL2325181 T3 PL 2325181T3 PL 09794208 T PL09794208 T PL 09794208T PL 09794208 T PL09794208 T PL 09794208T PL 2325181 T3 PL2325181 T3 PL 2325181T3
- Authority
- PL
- Poland
- Prior art keywords
- active ingredient
- inhibitor containing
- stat3 inhibitor
- quinolinecarboxamide derivative
- quinolinecarboxamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008180433 | 2008-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2325181T3 true PL2325181T3 (pl) | 2017-09-29 |
Family
ID=41506885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL09794208T PL2325181T3 (pl) | 2008-07-10 | 2009-07-10 | Inhibitor STAT3 zawierający jako składnik aktywny pochodną chinolinokarboksyamidu |
Country Status (12)
Country | Link |
---|---|
US (1) | US8466290B2 (pl) |
EP (1) | EP2325181B1 (pl) |
JP (1) | JP5650529B2 (pl) |
KR (1) | KR101696936B1 (pl) |
CN (1) | CN102099352B (pl) |
AU (1) | AU2009269410B2 (pl) |
CA (1) | CA2729988C (pl) |
EA (1) | EA021306B1 (pl) |
ES (1) | ES2622575T3 (pl) |
NZ (2) | NZ590355A (pl) |
PL (1) | PL2325181T3 (pl) |
WO (1) | WO2010004761A1 (pl) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2610248T3 (es) * | 2009-12-28 | 2017-04-26 | General Incorporated Association Pharma Valley Project Supporting Organisation | Compuesto de 1,3,4-oxadiazol-2-carboxamida |
JP5855113B2 (ja) * | 2010-10-08 | 2016-02-09 | ニヴァリス・セラピューティクス・インコーポレーテッド | S−ニトロソグルタチオン還元酵素阻害薬としての新規置換キノリン化合物 |
US20140275224A1 (en) * | 2010-11-05 | 2014-09-18 | Regents Of The University Of Minnesota | Cytosine deaminase modulators for enhancement of dna transfection |
WO2012121168A1 (ja) * | 2011-03-04 | 2012-09-13 | 国立大学法人京都大学 | キナーゼ阻害剤 |
CN102827142B (zh) * | 2011-06-17 | 2014-11-12 | 中国科学院上海药物研究所 | 一类喹啉-8-甲酰胺类化合物、其制备方法及其医药用途 |
CN102417479B (zh) * | 2011-08-29 | 2014-02-26 | 南京大学 | Stat3小分子选择性抑制剂及其制备方法和应用 |
CN110003104A (zh) * | 2012-05-25 | 2019-07-12 | 多伦多大学管理委员会 | 水杨酸衍生物、其药学上可接受的盐、其组合物以及其使用方法 |
US8791067B2 (en) | 2012-07-24 | 2014-07-29 | Morehouse School Of Medicine | Method for treating malaria |
CN103910727B (zh) * | 2012-12-31 | 2016-06-15 | 北京大学 | STAT3-Hif1α信号通路抑制剂及其在抗肿瘤中的应用 |
KR102260403B1 (ko) * | 2013-06-05 | 2021-06-04 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
WO2015106272A1 (en) * | 2014-01-13 | 2015-07-16 | Harki Daniel A | Small molecule inhibitors of apobec3g and apobec3b |
US11406707B2 (en) | 2014-02-10 | 2022-08-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | STAT3 phosphorylation during graft-versus-host disease |
KR20160066490A (ko) * | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
WO2016202935A1 (en) * | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
WO2018058029A1 (en) | 2016-09-26 | 2018-03-29 | Dana-Farber Cancer Institute, Inc. | Chromobox protein inhibitors and uses thereof |
CN112204010B (zh) | 2018-05-31 | 2024-03-19 | C&C新药研究所 | 杂环衍生物及其用途 |
WO2020059705A1 (ja) * | 2018-09-18 | 2020-03-26 | 株式会社ヤクルト本社 | キノリンカルボキサミド誘導体を用いるがん併用療法 |
WO2020196327A1 (ja) * | 2019-03-22 | 2020-10-01 | 株式会社ヤクルト本社 | キノリンカルボキサミド誘導体又はその製造中間体の製造法 |
EP3946623A1 (en) * | 2019-03-28 | 2022-02-09 | Epizyme Inc | Quinoline derivatives and their use for the treatment of cancer |
WO2020219792A1 (en) * | 2019-04-26 | 2020-10-29 | Purdue Research Foundation | Cf3-, ocf3-, scf3- and sf5-containing antibacterial agents |
JPWO2020218432A1 (pl) * | 2019-04-26 | 2020-10-29 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
AU4971400A (en) | 1999-08-12 | 2001-03-13 | Pharmacia & Upjohn Company | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
CA2389280C (en) * | 1999-11-15 | 2009-01-27 | Janssen Pharmaceutica N.V. | Triazoles as farnesyl transferase inhibitors |
US7049324B1 (en) | 1999-11-15 | 2006-05-23 | Ashis Kumar Saha | Triazoles as farnesyl transferase inhibitors |
GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
JP4681302B2 (ja) * | 2002-05-06 | 2011-05-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | チアジアゾールまたはオキサジアゾール、およびこれらの、jakプロテインキナーゼのインヒビターとしての使用 |
TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
WO2004078731A1 (fr) | 2003-03-06 | 2004-09-16 | 'chemical Diversity Research Institute', Ltd. | Acides quinoline-carboxyliques et leurs derives et bibliotheque focalisee |
JPWO2006051704A1 (ja) | 2004-11-15 | 2008-05-29 | 大正製薬株式会社 | イミン化合物 |
US20090069301A1 (en) | 2005-03-03 | 2009-03-12 | Sirtris Pharmaceuticals, Inc. | Acridine and Quinoline Derivatives as Sirtuin Modulators |
CN101410392A (zh) | 2006-01-27 | 2009-04-15 | 阿斯利康(瑞典)有限公司 | 酰胺取代的喹啉类化合物 |
WO2007133773A2 (en) * | 2006-05-15 | 2007-11-22 | Senex Biotechnology, Inc | Identification of cdki pathway inhibitors |
UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
-
2009
- 2009-07-10 PL PL09794208T patent/PL2325181T3/pl unknown
- 2009-07-10 NZ NZ590355A patent/NZ590355A/xx unknown
- 2009-07-10 CN CN200980126951.0A patent/CN102099352B/zh active Active
- 2009-07-10 KR KR1020107029688A patent/KR101696936B1/ko active IP Right Grant
- 2009-07-10 EA EA201170176A patent/EA021306B1/ru not_active IP Right Cessation
- 2009-07-10 AU AU2009269410A patent/AU2009269410B2/en active Active
- 2009-07-10 EP EP09794208.0A patent/EP2325181B1/en active Active
- 2009-07-10 JP JP2010519655A patent/JP5650529B2/ja not_active Expired - Fee Related
- 2009-07-10 CA CA2729988A patent/CA2729988C/en active Active
- 2009-07-10 WO PCT/JP2009/003235 patent/WO2010004761A1/ja active Application Filing
- 2009-07-10 NZ NZ602099A patent/NZ602099A/en unknown
- 2009-07-10 ES ES09794208.0T patent/ES2622575T3/es active Active
- 2009-07-10 US US13/003,441 patent/US8466290B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2325181B1 (en) | 2017-03-29 |
KR20110039221A (ko) | 2011-04-15 |
EP2325181A1 (en) | 2011-05-25 |
US8466290B2 (en) | 2013-06-18 |
WO2010004761A1 (ja) | 2010-01-14 |
NZ602099A (en) | 2014-06-27 |
EP2325181A4 (en) | 2012-03-07 |
EA021306B1 (ru) | 2015-05-29 |
AU2009269410A1 (en) | 2010-01-14 |
CN102099352A (zh) | 2011-06-15 |
EA201170176A1 (ru) | 2011-08-30 |
AU2009269410B2 (en) | 2013-12-05 |
NZ590355A (en) | 2013-01-25 |
CA2729988C (en) | 2016-09-13 |
JP5650529B2 (ja) | 2015-01-07 |
JPWO2010004761A1 (ja) | 2011-12-22 |
US20110172429A1 (en) | 2011-07-14 |
KR101696936B1 (ko) | 2017-01-16 |
CN102099352B (zh) | 2014-02-26 |
CA2729988A1 (en) | 2010-01-14 |
ES2622575T3 (es) | 2017-07-06 |
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