CO6870035A2 - Nuevos derivados bicíclicos de dihidroquinolina-2-ona - Google Patents
Nuevos derivados bicíclicos de dihidroquinolina-2-onaInfo
- Publication number
- CO6870035A2 CO6870035A2 CO14020664A CO14020664A CO6870035A2 CO 6870035 A2 CO6870035 A2 CO 6870035A2 CO 14020664 A CO14020664 A CO 14020664A CO 14020664 A CO14020664 A CO 14020664A CO 6870035 A2 CO6870035 A2 CO 6870035A2
- Authority
- CO
- Colombia
- Prior art keywords
- dihydroquinoline
- bicyclic derivatives
- new bicyclic
- new
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011080078 | 2011-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6870035A2 true CO6870035A2 (es) | 2014-02-20 |
Family
ID=46963698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14020664A CO6870035A2 (es) | 2011-09-23 | 2014-01-31 | Nuevos derivados bicíclicos de dihidroquinolina-2-ona |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US9353081B2 (es) |
| EP (1) | EP2758388B1 (es) |
| JP (1) | JP6012737B2 (es) |
| KR (1) | KR101723276B1 (es) |
| CN (1) | CN103827101B (es) |
| AR (1) | AR087984A1 (es) |
| AU (1) | AU2012311582B2 (es) |
| BR (1) | BR112014006660B1 (es) |
| CA (1) | CA2845170C (es) |
| CL (1) | CL2014000663A1 (es) |
| CO (1) | CO6870035A2 (es) |
| CR (1) | CR20140089A (es) |
| DK (1) | DK2758388T3 (es) |
| EA (1) | EA035108B1 (es) |
| EC (1) | ECSP14013264A (es) |
| ES (1) | ES2666802T3 (es) |
| HR (1) | HRP20180592T1 (es) |
| HU (1) | HUE038773T2 (es) |
| IL (1) | IL230874A (es) |
| LT (1) | LT2758388T (es) |
| MX (1) | MX366095B (es) |
| MY (1) | MY186165A (es) |
| NO (1) | NO2758388T3 (es) |
| PE (2) | PE20141042A1 (es) |
| PL (1) | PL2758388T3 (es) |
| PT (1) | PT2758388T (es) |
| RS (1) | RS57139B1 (es) |
| SG (1) | SG2014010599A (es) |
| SI (1) | SI2758388T1 (es) |
| TW (1) | TWI576342B (es) |
| UA (1) | UA115972C2 (es) |
| WO (1) | WO2013041591A1 (es) |
| ZA (1) | ZA201401577B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| DK2838883T3 (en) * | 2012-04-17 | 2018-01-15 | Hoffmann La Roche | New phenyl-tetrahydroisoquinoline derivatives |
| WO2014076162A1 (en) | 2012-11-19 | 2014-05-22 | Bayer Pharma Aktiengesellschaft | Aminoimidazopyridazines |
| EP2970198B1 (en) * | 2013-03-14 | 2020-08-05 | F.Hoffmann-La Roche Ag | Dihydroquinoline-2-one derivatives for use as aldosterone synthase inhibitors |
| ES2804271T3 (es) * | 2013-05-27 | 2021-02-05 | Hoffmann La Roche | Nuevos compuestos de 3,4-dihidro-2H-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona |
| MX370389B (es) * | 2013-05-27 | 2019-12-11 | Hoffmann La Roche | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. |
| MX368759B (es) * | 2013-05-27 | 2019-10-15 | Hoffmann La Roche | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. |
| RU2016116433A (ru) * | 2013-10-17 | 2017-11-22 | Ф. Хоффманн-Ля Рош Аг | Новые производные фенил-дигидропиридина в качестве ингибиторов альдостерон синтазы |
| CN105593212B (zh) * | 2013-10-17 | 2019-06-04 | 豪夫迈·罗氏有限公司 | 作为醛固酮合酶抑制剂的苯基-二氢吡啶衍生物 |
| WO2015055602A1 (en) * | 2013-10-17 | 2015-04-23 | F. Hoffmann-La Roche Ag | Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase |
| JP6670832B2 (ja) * | 2014-10-31 | 2020-03-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルドステロン合成酵素阻害剤としての新規ジヒドロキノリンピラゾリル化合物 |
| WO2016066663A1 (en) * | 2014-10-31 | 2016-05-06 | F. Hoffmann-La Roche Ag | Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors |
| EP3212630B1 (en) * | 2014-10-31 | 2022-05-18 | F. Hoffmann-La Roche AG | New dihydroquinoline pyrazolyl compounds |
| JP6707084B2 (ja) | 2014-12-02 | 2020-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルドステロンシンターゼ阻害薬 |
| WO2017213247A1 (ja) * | 2016-06-10 | 2017-12-14 | 日本メジフィジックス株式会社 | 心疾患の非侵襲的画像診断剤 |
| CN113767095A (zh) | 2019-05-01 | 2021-12-07 | 勃林格殷格翰国际有限公司 | (r)-4-溴苯磺酸(2-甲基环氧乙烷-2-基)甲酯 |
| CA3223211A1 (en) * | 2021-06-24 | 2022-12-29 | Cincor Pharma, Inc. | Methods of using aldosterone synthase inhibitors |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| WO2024049885A1 (en) | 2022-09-02 | 2024-03-07 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
| WO2024061371A1 (zh) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| GB8709448D0 (en) | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| US5246944A (en) * | 1991-08-13 | 1993-09-21 | Merck & Co., Inc. | Quinoline angiotensin ii antagonists incorporating a substituted benzyl element |
| WO2005065050A2 (ja) * | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | ２環化合物 |
| CA2634168C (en) | 2005-12-09 | 2013-04-23 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
-
2012
- 2012-09-14 US US13/615,901 patent/US9353081B2/en active Active
- 2012-09-20 DK DK12766628.7T patent/DK2758388T3/en active
- 2012-09-20 CN CN201280045785.3A patent/CN103827101B/zh active Active
- 2012-09-20 KR KR1020147010662A patent/KR101723276B1/ko active IP Right Grant
- 2012-09-20 LT LTEP12766628.7T patent/LT2758388T/lt unknown
- 2012-09-20 RS RS20180446A patent/RS57139B1/sr unknown
- 2012-09-20 PT PT127666287T patent/PT2758388T/pt unknown
- 2012-09-20 MY MYPI2014700679A patent/MY186165A/en unknown
- 2012-09-20 SI SI201231277T patent/SI2758388T1/en unknown
- 2012-09-20 WO PCT/EP2012/068472 patent/WO2013041591A1/en active Application Filing
- 2012-09-20 JP JP2014531214A patent/JP6012737B2/ja active Active
- 2012-09-20 SG SG2014010599A patent/SG2014010599A/en unknown
- 2012-09-20 AU AU2012311582A patent/AU2012311582B2/en active Active
- 2012-09-20 CA CA2845170A patent/CA2845170C/en active Active
- 2012-09-20 MX MX2014002624A patent/MX366095B/es active IP Right Grant
- 2012-09-20 EA EA201490567A patent/EA035108B1/ru not_active IP Right Cessation
- 2012-09-20 PE PE2014000393A patent/PE20141042A1/es active IP Right Grant
- 2012-09-20 HU HUE12766628A patent/HUE038773T2/hu unknown
- 2012-09-20 BR BR112014006660-4A patent/BR112014006660B1/pt active IP Right Grant
- 2012-09-20 PL PL12766628T patent/PL2758388T3/pl unknown
- 2012-09-20 PE PE2018001330A patent/PE20181378A1/es unknown
- 2012-09-20 EP EP12766628.7A patent/EP2758388B1/en active Active
- 2012-09-20 NO NO12766628A patent/NO2758388T3/no unknown
- 2012-09-20 UA UAA201404207A patent/UA115972C2/uk unknown
- 2012-09-20 ES ES12766628.7T patent/ES2666802T3/es active Active
- 2012-09-21 AR ARP120103485A patent/AR087984A1/es active IP Right Grant
- 2012-09-21 TW TW101134790A patent/TWI576342B/zh active
-
2014
- 2014-01-31 CO CO14020664A patent/CO6870035A2/es active IP Right Grant
- 2014-02-06 IL IL230874A patent/IL230874A/en active IP Right Grant
- 2014-02-25 CR CR20140089A patent/CR20140089A/es unknown
- 2014-02-28 ZA ZA2014/01577A patent/ZA201401577B/en unknown
- 2014-03-19 CL CL2014000663A patent/CL2014000663A1/es unknown
- 2014-03-21 EC ECSP14013264 patent/ECSP14013264A/es unknown
-
2018
- 2018-04-13 HR HRP20180592TT patent/HRP20180592T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |