MX366095B - Nuevos derivados biciclicos de dihidroquinolina-2-ona. - Google Patents
Nuevos derivados biciclicos de dihidroquinolina-2-ona.Info
- Publication number
- MX366095B MX366095B MX2014002624A MX2014002624A MX366095B MX 366095 B MX366095 B MX 366095B MX 2014002624 A MX2014002624 A MX 2014002624A MX 2014002624 A MX2014002624 A MX 2014002624A MX 366095 B MX366095 B MX 366095B
- Authority
- MX
- Mexico
- Prior art keywords
- dihydroquinoline
- derivatives
- new bicyclic
- compounds
- bicyclic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona nuevos compuestos que poseen la fórmula general (I) en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 A3 y n son tal como se ha descrito aquí, las composiciones que incluyen los compuestos y los métodos para utilizar los compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011080078 | 2011-09-23 | ||
PCT/EP2012/068472 WO2013041591A1 (en) | 2011-09-23 | 2012-09-20 | New bicyclic dihydroquinoline-2-one derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014002624A MX2014002624A (es) | 2014-04-14 |
MX366095B true MX366095B (es) | 2019-06-27 |
Family
ID=46963698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014002624A MX366095B (es) | 2011-09-23 | 2012-09-20 | Nuevos derivados biciclicos de dihidroquinolina-2-ona. |
Country Status (33)
Country | Link |
---|---|
US (1) | US9353081B2 (es) |
EP (1) | EP2758388B1 (es) |
JP (1) | JP6012737B2 (es) |
KR (1) | KR101723276B1 (es) |
CN (1) | CN103827101B (es) |
AR (1) | AR087984A1 (es) |
AU (1) | AU2012311582B2 (es) |
BR (1) | BR112014006660B1 (es) |
CA (1) | CA2845170C (es) |
CL (1) | CL2014000663A1 (es) |
CO (1) | CO6870035A2 (es) |
CR (1) | CR20140089A (es) |
DK (1) | DK2758388T3 (es) |
EA (1) | EA035108B1 (es) |
EC (1) | ECSP14013264A (es) |
ES (1) | ES2666802T3 (es) |
HR (1) | HRP20180592T1 (es) |
HU (1) | HUE038773T2 (es) |
IL (1) | IL230874A (es) |
LT (1) | LT2758388T (es) |
MX (1) | MX366095B (es) |
MY (1) | MY186165A (es) |
NO (1) | NO2758388T3 (es) |
PE (2) | PE20181378A1 (es) |
PL (1) | PL2758388T3 (es) |
PT (1) | PT2758388T (es) |
RS (1) | RS57139B1 (es) |
SG (1) | SG2014010599A (es) |
SI (1) | SI2758388T1 (es) |
TW (1) | TWI576342B (es) |
UA (1) | UA115972C2 (es) |
WO (1) | WO2013041591A1 (es) |
ZA (1) | ZA201401577B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
CA2861060A1 (en) * | 2012-04-17 | 2013-10-24 | F. Hoffmann-La Roche Ag | New phenyl-tetrahydroisoquinoline derivatives |
ES2646916T3 (es) | 2012-11-19 | 2017-12-18 | Bayer Pharma Aktiengesellschaft | Aminoimidazopiridazinas como inhibidores de MKNK1 cinasa |
MX2015011005A (es) * | 2013-03-14 | 2015-10-22 | Hoffmann La Roche | Derivados de dihidorquinolin-2-ona para usarse como inhibidores de aldoesterona sintasa. |
LT3004076T (lt) * | 2013-05-27 | 2020-01-10 | F. Hoffmann-La Roche Ag | Nauji 3,4-dihidro-2h-izochinolin-1-ono ir 2,3-dihidro-izoindol-1-ono junginiai |
SI3004077T1 (sl) * | 2013-05-27 | 2020-01-31 | F. Hoffmann-La Roche Ag | Novi spojini 3,4-dihidro-2H-izokinolin-1-on in 2,3-dihidro-izoindol-1-on |
EP3004089B1 (en) * | 2013-05-27 | 2020-05-06 | F.Hoffmann-La Roche Ag | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
RU2016116435A (ru) * | 2013-10-17 | 2017-11-22 | Ф. Хоффманн-Ля Рош Аг | Производные фенил-дигидропиридина в качестве ингибиторов альдостеронсинтазы |
CN105593212B (zh) * | 2013-10-17 | 2019-06-04 | 豪夫迈·罗氏有限公司 | 作为醛固酮合酶抑制剂的苯基-二氢吡啶衍生物 |
WO2015055604A1 (en) * | 2013-10-17 | 2015-04-23 | F. Hoffmann-La Roche Ag | New phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors |
CN106604917B (zh) * | 2014-10-31 | 2020-10-09 | 豪夫迈·罗氏有限公司 | 作为醛固酮合酶抑制剂的新型二氢喹啉吡唑基化合物 |
JP6622300B2 (ja) * | 2014-10-31 | 2019-12-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新規なジヒドロキノリンピラゾリル化合物 |
CN106660998B (zh) * | 2014-10-31 | 2019-10-25 | 豪夫迈·罗氏有限公司 | 吡唑基-3,4-二氢喹啉-2-酮醛固酮合酶抑制剂 |
WO2016089800A1 (en) * | 2014-12-02 | 2016-06-09 | Boehringer Ingelheim International Gmbh | Aldosterone synthase inhibitors |
KR20190016971A (ko) | 2016-06-10 | 2019-02-19 | 니혼 메디피직스 가부시키가이샤 | 심질환의 비침습적 화상 진단제 |
JP2022530775A (ja) | 2019-05-01 | 2022-07-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | (r)-(2-メチルオキシラン-2-イル)メチル 4-ブロモベンゼンスルホネート |
EP4358959A1 (en) * | 2021-06-24 | 2024-05-01 | Cincor Pharma, Inc. | Methods of using aldosterone synthase inhibitors |
WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
WO2024049885A1 (en) | 2022-09-02 | 2024-03-07 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
WO2024061371A1 (zh) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用 |
WO2024109885A1 (zh) * | 2022-11-23 | 2024-05-30 | 上海翰森生物医药科技有限公司 | 吡啶多环类化合物抑制剂、及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
GB8709448D0 (en) | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
US5246944A (en) * | 1991-08-13 | 1993-09-21 | Merck & Co., Inc. | Quinoline angiotensin ii antagonists incorporating a substituted benzyl element |
WO2005065050A2 (ja) * | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | 2環化合物 |
AU2006326662B2 (en) | 2005-12-09 | 2011-07-28 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof |
DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
-
2012
- 2012-09-14 US US13/615,901 patent/US9353081B2/en active Active
- 2012-09-20 WO PCT/EP2012/068472 patent/WO2013041591A1/en active Application Filing
- 2012-09-20 PT PT127666287T patent/PT2758388T/pt unknown
- 2012-09-20 PE PE2018001330A patent/PE20181378A1/es unknown
- 2012-09-20 UA UAA201404207A patent/UA115972C2/uk unknown
- 2012-09-20 SI SI201231277T patent/SI2758388T1/en unknown
- 2012-09-20 NO NO12766628A patent/NO2758388T3/no unknown
- 2012-09-20 KR KR1020147010662A patent/KR101723276B1/ko active IP Right Grant
- 2012-09-20 EP EP12766628.7A patent/EP2758388B1/en active Active
- 2012-09-20 RS RS20180446A patent/RS57139B1/sr unknown
- 2012-09-20 SG SG2014010599A patent/SG2014010599A/en unknown
- 2012-09-20 HU HUE12766628A patent/HUE038773T2/hu unknown
- 2012-09-20 CN CN201280045785.3A patent/CN103827101B/zh active Active
- 2012-09-20 BR BR112014006660-4A patent/BR112014006660B1/pt active IP Right Grant
- 2012-09-20 DK DK12766628.7T patent/DK2758388T3/en active
- 2012-09-20 PE PE2014000393A patent/PE20141042A1/es active IP Right Grant
- 2012-09-20 AU AU2012311582A patent/AU2012311582B2/en active Active
- 2012-09-20 CA CA2845170A patent/CA2845170C/en active Active
- 2012-09-20 MY MYPI2014700679A patent/MY186165A/en unknown
- 2012-09-20 MX MX2014002624A patent/MX366095B/es active IP Right Grant
- 2012-09-20 JP JP2014531214A patent/JP6012737B2/ja active Active
- 2012-09-20 EA EA201490567A patent/EA035108B1/ru not_active IP Right Cessation
- 2012-09-20 LT LTEP12766628.7T patent/LT2758388T/lt unknown
- 2012-09-20 ES ES12766628.7T patent/ES2666802T3/es active Active
- 2012-09-20 PL PL12766628T patent/PL2758388T3/pl unknown
- 2012-09-21 TW TW101134790A patent/TWI576342B/zh active
- 2012-09-21 AR ARP120103485A patent/AR087984A1/es active IP Right Grant
-
2014
- 2014-01-31 CO CO14020664A patent/CO6870035A2/es active IP Right Grant
- 2014-02-06 IL IL230874A patent/IL230874A/en active IP Right Grant
- 2014-02-25 CR CR20140089A patent/CR20140089A/es unknown
- 2014-02-28 ZA ZA2014/01577A patent/ZA201401577B/en unknown
- 2014-03-19 CL CL2014000663A patent/CL2014000663A1/es unknown
- 2014-03-21 EC ECSP14013264 patent/ECSP14013264A/es unknown
-
2018
- 2018-04-13 HR HRP20180592TT patent/HRP20180592T1/hr unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |