MX368759B - Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. - Google Patents
Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.Info
- Publication number
- MX368759B MX368759B MX2015015058A MX2015015058A MX368759B MX 368759 B MX368759 B MX 368759B MX 2015015058 A MX2015015058 A MX 2015015058A MX 2015015058 A MX2015015058 A MX 2015015058A MX 368759 B MX368759 B MX 368759B
- Authority
- MX
- Mexico
- Prior art keywords
- dihydro
- compounds
- isoindol
- isoquinoline
- new
- Prior art date
Links
- YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical compound C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 title 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención proporciona nuevos compuestos que tienen la fórmula general (I) en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R12, R13, R14, R15, A, m, n y p son tal como se describe en el presente documento, composiciones que incluyen los compuestos y métodos de uso de los compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013076285 | 2013-05-27 | ||
PCT/EP2014/060794 WO2014191340A1 (en) | 2013-05-27 | 2014-05-26 | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015015058A MX2015015058A (es) | 2016-02-11 |
MX368759B true MX368759B (es) | 2019-10-15 |
Family
ID=50819739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015015058A MX368759B (es) | 2013-05-27 | 2014-05-26 | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. |
Country Status (20)
Country | Link |
---|---|
US (1) | US9695152B2 (es) |
EP (1) | EP3004076B1 (es) |
JP (2) | JP6416230B2 (es) |
AR (1) | AR096425A1 (es) |
BR (1) | BR112015029691B1 (es) |
CA (1) | CA2902848C (es) |
DK (1) | DK3004076T3 (es) |
ES (1) | ES2763424T3 (es) |
HK (1) | HK1213556A1 (es) |
HR (1) | HRP20192242T1 (es) |
HU (1) | HUE046739T2 (es) |
LT (1) | LT3004076T (es) |
MX (1) | MX368759B (es) |
PL (1) | PL3004076T3 (es) |
PT (1) | PT3004076T (es) |
RS (1) | RS59663B1 (es) |
RU (1) | RU2693698C2 (es) |
SI (1) | SI3004076T1 (es) |
TW (1) | TWI704143B (es) |
WO (1) | WO2014191340A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3004077T1 (sl) * | 2013-05-27 | 2020-01-31 | F. Hoffmann-La Roche Ag | Novi spojini 3,4-dihidro-2H-izokinolin-1-on in 2,3-dihidro-izoindol-1-on |
BR112017006829B1 (pt) * | 2014-10-08 | 2023-01-31 | F. Hoffmann-La Roche Ag | Derivados de espirodiamina como inibidores de aldosterona sintase |
EP3732163A4 (en) * | 2017-12-20 | 2021-07-14 | Vanderbilt University | MUSCARINIAN ACETYLCHOLINE RECEPTOR ANTAGONISTS M4 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6482951B2 (en) * | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
US8946260B2 (en) * | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
BR112014006283B1 (pt) * | 2011-09-15 | 2021-11-03 | F. Hoffmann-La Roche Ag | Novos derivados de dihidroquinolina-2-ona |
US9353081B2 (en) * | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
-
2014
- 2014-05-26 LT LTEP14726363.6T patent/LT3004076T/lt unknown
- 2014-05-26 RU RU2015149956A patent/RU2693698C2/ru active
- 2014-05-26 TW TW103118319A patent/TWI704143B/zh active
- 2014-05-26 SI SI201431431T patent/SI3004076T1/sl unknown
- 2014-05-26 EP EP14726363.6A patent/EP3004076B1/en active Active
- 2014-05-26 CA CA2902848A patent/CA2902848C/en active Active
- 2014-05-26 HU HUE14726363A patent/HUE046739T2/hu unknown
- 2014-05-26 PT PT147263636T patent/PT3004076T/pt unknown
- 2014-05-26 ES ES14726363T patent/ES2763424T3/es active Active
- 2014-05-26 MX MX2015015058A patent/MX368759B/es active IP Right Grant
- 2014-05-26 RS RS20191616A patent/RS59663B1/sr unknown
- 2014-05-26 JP JP2016515760A patent/JP6416230B2/ja active Active
- 2014-05-26 DK DK14726363.6T patent/DK3004076T3/da active
- 2014-05-26 BR BR112015029691-2A patent/BR112015029691B1/pt active IP Right Grant
- 2014-05-26 PL PL14726363T patent/PL3004076T3/pl unknown
- 2014-05-26 WO PCT/EP2014/060794 patent/WO2014191340A1/en active Application Filing
- 2014-05-26 AR ARP140102073A patent/AR096425A1/es active IP Right Grant
-
2015
- 2015-11-20 US US14/947,768 patent/US9695152B2/en active Active
-
2016
- 2016-02-11 HK HK16101487.0A patent/HK1213556A1/zh unknown
-
2018
- 2018-10-03 JP JP2018188236A patent/JP2019014738A/ja active Pending
-
2019
- 2019-12-12 HR HRP20192242TT patent/HRP20192242T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
RU2693698C2 (ru) | 2019-07-04 |
EP3004076A1 (en) | 2016-04-13 |
EP3004076B1 (en) | 2019-10-23 |
BR112015029691B1 (pt) | 2023-03-28 |
JP2016520106A (ja) | 2016-07-11 |
BR112015029691A2 (pt) | 2017-07-25 |
US20160075688A1 (en) | 2016-03-17 |
TWI704143B (zh) | 2020-09-11 |
JP6416230B2 (ja) | 2018-10-31 |
HK1213556A1 (zh) | 2016-07-08 |
WO2014191340A1 (en) | 2014-12-04 |
RU2015149956A3 (es) | 2018-03-19 |
MX2015015058A (es) | 2016-02-11 |
SI3004076T1 (sl) | 2020-02-28 |
TW201534596A (zh) | 2015-09-16 |
HUE046739T2 (hu) | 2020-03-30 |
HRP20192242T1 (hr) | 2020-03-06 |
AR096425A1 (es) | 2015-12-30 |
RS59663B1 (sr) | 2020-01-31 |
PL3004076T3 (pl) | 2020-04-30 |
PT3004076T (pt) | 2019-12-18 |
ES2763424T3 (es) | 2020-05-28 |
JP2019014738A (ja) | 2019-01-31 |
LT3004076T (lt) | 2020-01-10 |
US9695152B2 (en) | 2017-07-04 |
RU2015149956A (ru) | 2017-07-04 |
DK3004076T3 (da) | 2020-01-02 |
CA2902848A1 (en) | 2014-12-04 |
CA2902848C (en) | 2021-09-21 |
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Legal Events
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