MX368759B - Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. - Google Patents
Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.Info
- Publication number
- MX368759B MX368759B MX2015015058A MX2015015058A MX368759B MX 368759 B MX368759 B MX 368759B MX 2015015058 A MX2015015058 A MX 2015015058A MX 2015015058 A MX2015015058 A MX 2015015058A MX 368759 B MX368759 B MX 368759B
- Authority
- MX
- Mexico
- Prior art keywords
- dihydro
- compounds
- isoindol
- isoquinoline
- new
- Prior art date
Links
- YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical compound C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 title 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención proporciona nuevos compuestos que tienen la fórmula general (I) en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R12, R13, R14, R15, A, m, n y p son tal como se describe en el presente documento, composiciones que incluyen los compuestos y métodos de uso de los compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013076285 | 2013-05-27 | ||
| PCT/EP2014/060794 WO2014191340A1 (en) | 2013-05-27 | 2014-05-26 | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015015058A MX2015015058A (es) | 2016-02-11 |
| MX368759B true MX368759B (es) | 2019-10-15 |
Family
ID=50819739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015015058A MX368759B (es) | 2013-05-27 | 2014-05-26 | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9695152B2 (es) |
| EP (1) | EP3004076B1 (es) |
| JP (2) | JP6416230B2 (es) |
| AR (1) | AR096425A1 (es) |
| BR (1) | BR112015029691B1 (es) |
| CA (1) | CA2902848C (es) |
| DK (1) | DK3004076T3 (es) |
| ES (1) | ES2763424T3 (es) |
| HR (1) | HRP20192242T1 (es) |
| HU (1) | HUE046739T2 (es) |
| LT (1) | LT3004076T (es) |
| MX (1) | MX368759B (es) |
| PL (1) | PL3004076T3 (es) |
| PT (1) | PT3004076T (es) |
| RS (1) | RS59663B1 (es) |
| RU (1) | RU2693698C2 (es) |
| SI (1) | SI3004076T1 (es) |
| TW (1) | TWI704143B (es) |
| WO (1) | WO2014191340A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI651317B (zh) * | 2013-05-27 | 2019-02-21 | 赫孚孟拉羅股份公司 | 新穎３，４－二氫－２ｈ－異喹啉－１－酮及２，３－二氫異吲哚－１－酮化合物 |
| PE20171057A1 (es) * | 2014-10-08 | 2017-07-21 | Hoffmann La Roche | Derivados espirodiamina como inhibidores de la aldosterona sintasa |
| US11299481B2 (en) | 2017-10-20 | 2022-04-12 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
| EP3732163A4 (en) * | 2017-12-20 | 2021-07-14 | Vanderbilt University | MUSCARIN M4 ACETYLCHOLIN RECEPTOR ANTAGONISTS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482951B2 (en) * | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2627648A1 (en) * | 2010-09-16 | 2013-08-21 | Novartis AG | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS |
| JP6012735B2 (ja) * | 2011-09-15 | 2016-10-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規ジヒドロキノリン−２−オン誘導体 |
| US9353081B2 (en) * | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
-
2014
- 2014-05-26 RU RU2015149956A patent/RU2693698C2/ru active
- 2014-05-26 LT LTEP14726363.6T patent/LT3004076T/lt unknown
- 2014-05-26 EP EP14726363.6A patent/EP3004076B1/en active Active
- 2014-05-26 CA CA2902848A patent/CA2902848C/en active Active
- 2014-05-26 HU HUE14726363A patent/HUE046739T2/hu unknown
- 2014-05-26 BR BR112015029691-2A patent/BR112015029691B1/pt not_active IP Right Cessation
- 2014-05-26 JP JP2016515760A patent/JP6416230B2/ja active Active
- 2014-05-26 PT PT147263636T patent/PT3004076T/pt unknown
- 2014-05-26 WO PCT/EP2014/060794 patent/WO2014191340A1/en not_active Ceased
- 2014-05-26 RS RS20191616A patent/RS59663B1/sr unknown
- 2014-05-26 TW TW103118319A patent/TWI704143B/zh not_active IP Right Cessation
- 2014-05-26 DK DK14726363.6T patent/DK3004076T3/da active
- 2014-05-26 HR HRP20192242TT patent/HRP20192242T1/hr unknown
- 2014-05-26 SI SI201431431T patent/SI3004076T1/sl unknown
- 2014-05-26 AR ARP140102073A patent/AR096425A1/es active IP Right Grant
- 2014-05-26 PL PL14726363T patent/PL3004076T3/pl unknown
- 2014-05-26 MX MX2015015058A patent/MX368759B/es active IP Right Grant
- 2014-05-26 ES ES14726363T patent/ES2763424T3/es active Active
-
2015
- 2015-11-20 US US14/947,768 patent/US9695152B2/en active Active
-
2018
- 2018-10-03 JP JP2018188236A patent/JP2019014738A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2015149956A3 (es) | 2018-03-19 |
| JP2016520106A (ja) | 2016-07-11 |
| RU2015149956A (ru) | 2017-07-04 |
| US20160075688A1 (en) | 2016-03-17 |
| TW201534596A (zh) | 2015-09-16 |
| EP3004076A1 (en) | 2016-04-13 |
| WO2014191340A1 (en) | 2014-12-04 |
| HK1213556A1 (zh) | 2016-07-08 |
| JP6416230B2 (ja) | 2018-10-31 |
| BR112015029691A2 (pt) | 2017-07-25 |
| HRP20192242T1 (hr) | 2020-03-06 |
| CA2902848A1 (en) | 2014-12-04 |
| EP3004076B1 (en) | 2019-10-23 |
| SI3004076T1 (sl) | 2020-02-28 |
| CA2902848C (en) | 2021-09-21 |
| US9695152B2 (en) | 2017-07-04 |
| TWI704143B (zh) | 2020-09-11 |
| LT3004076T (lt) | 2020-01-10 |
| MX2015015058A (es) | 2016-02-11 |
| RU2693698C2 (ru) | 2019-07-04 |
| PT3004076T (pt) | 2019-12-18 |
| PL3004076T3 (pl) | 2020-04-30 |
| DK3004076T3 (da) | 2020-01-02 |
| JP2019014738A (ja) | 2019-01-31 |
| AR096425A1 (es) | 2015-12-30 |
| HUE046739T2 (hu) | 2020-03-30 |
| RS59663B1 (sr) | 2020-01-31 |
| ES2763424T3 (es) | 2020-05-28 |
| BR112015029691B1 (pt) | 2023-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |