MX370389B - Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. - Google Patents
Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.Info
- Publication number
- MX370389B MX370389B MX2015015010A MX2015015010A MX370389B MX 370389 B MX370389 B MX 370389B MX 2015015010 A MX2015015010 A MX 2015015010A MX 2015015010 A MX2015015010 A MX 2015015010A MX 370389 B MX370389 B MX 370389B
- Authority
- MX
- Mexico
- Prior art keywords
- dihydro
- compounds
- isoindol
- isoquinoline
- new
- Prior art date
Links
- YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical compound C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 title 1
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención proporciona nuevos compuestos que tienen la fórmula general (I) en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, A, m, n y p son tal como se describe en el presente documento, composiciones que incluyen los compuestos y métodos de uso de los compuestos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013076281 | 2013-05-27 | ||
| PCT/EP2014/060790 WO2014191338A1 (en) | 2013-05-27 | 2014-05-26 | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015015010A MX2015015010A (es) | 2016-03-09 |
| MX370389B true MX370389B (es) | 2019-12-11 |
Family
ID=50884887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015015010A MX370389B (es) | 2013-05-27 | 2014-05-26 | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9695151B2 (es) |
| EP (1) | EP3004077B1 (es) |
| JP (2) | JP6416229B2 (es) |
| KR (1) | KR102436885B1 (es) |
| CN (1) | CN105143204B (es) |
| AR (1) | AR096424A1 (es) |
| BR (1) | BR112015028871B1 (es) |
| CA (1) | CA2903180C (es) |
| DK (1) | DK3004077T3 (es) |
| ES (1) | ES2763338T3 (es) |
| HR (1) | HRP20192275T1 (es) |
| HU (1) | HUE046773T2 (es) |
| LT (1) | LT3004077T (es) |
| MX (1) | MX370389B (es) |
| PL (1) | PL3004077T3 (es) |
| PT (1) | PT3004077T (es) |
| RS (1) | RS59739B1 (es) |
| RU (1) | RU2695524C2 (es) |
| SI (1) | SI3004077T1 (es) |
| TW (1) | TWI651317B (es) |
| WO (1) | WO2014191338A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI651317B (zh) * | 2013-05-27 | 2019-02-21 | 赫孚孟拉羅股份公司 | 新穎３，４－二氫－２ｈ－異喹啉－１－酮及２，３－二氫異吲哚－１－酮化合物 |
| ES2749588T3 (es) | 2013-10-07 | 2020-03-23 | Antares Pharma Inc | Modulación de hematocrito mediante inyección de testosterona a chorro asistida por aguja |
| PE20171057A1 (es) * | 2014-10-08 | 2017-07-21 | Hoffmann La Roche | Derivados espirodiamina como inhibidores de la aldosterona sintasa |
| US11299481B2 (en) | 2017-10-20 | 2022-04-12 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
| EP3732163A4 (en) | 2017-12-20 | 2021-07-14 | Vanderbilt University | MUSCARIN M4 ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| RU2717310C1 (ru) * | 2019-06-04 | 2020-03-20 | Общество с ограниченной ответственностью "Таргет Медикалс" | Ингибиторы альдостеронсинтазы на основе производных 2-амино-4H-пиран-3-карбонитрила |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| CN85100796A (zh) * | 1985-04-01 | 1986-10-01 | 辉瑞公司 | 喹啉酮衍生物的制备方法 |
| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| US8541404B2 (en) * | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| EP2627648A1 (en) * | 2010-09-16 | 2013-08-21 | Novartis AG | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS |
| US9073929B2 (en) * | 2011-04-26 | 2015-07-07 | Elexopharm Gmbh | Aldosterone synthase inhibitors |
| JP6012735B2 (ja) * | 2011-09-15 | 2016-10-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規ジヒドロキノリン−２−オン誘導体 |
| US9353081B2 (en) * | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
| RU2693698C2 (ru) * | 2013-05-27 | 2019-07-04 | Ф. Хоффманн-Ля Рош Аг | Новые соединения 3,4-дигидро-2н-изохинолин-1-она и 2,3-дигидроизоиндол-1-она |
| TWI651317B (zh) * | 2013-05-27 | 2019-02-21 | 赫孚孟拉羅股份公司 | 新穎３，４－二氫－２ｈ－異喹啉－１－酮及２，３－二氫異吲哚－１－酮化合物 |
-
2014
- 2014-05-26 TW TW103118318A patent/TWI651317B/zh not_active IP Right Cessation
- 2014-05-26 JP JP2016515759A patent/JP6416229B2/ja active Active
- 2014-05-26 RS RS20191657A patent/RS59739B1/sr unknown
- 2014-05-26 CA CA2903180A patent/CA2903180C/en active Active
- 2014-05-26 AR ARP140102072A patent/AR096424A1/es active IP Right Grant
- 2014-05-26 LT LTEP14728131.5T patent/LT3004077T/lt unknown
- 2014-05-26 DK DK14728131.5T patent/DK3004077T3/da active
- 2014-05-26 HR HRP20192275TT patent/HRP20192275T1/hr unknown
- 2014-05-26 CN CN201480023886.XA patent/CN105143204B/zh active Active
- 2014-05-26 PL PL14728131T patent/PL3004077T3/pl unknown
- 2014-05-26 EP EP14728131.5A patent/EP3004077B1/en active Active
- 2014-05-26 BR BR112015028871-5A patent/BR112015028871B1/pt not_active IP Right Cessation
- 2014-05-26 ES ES14728131T patent/ES2763338T3/es active Active
- 2014-05-26 SI SI201431437T patent/SI3004077T1/sl unknown
- 2014-05-26 MX MX2015015010A patent/MX370389B/es active IP Right Grant
- 2014-05-26 KR KR1020157033719A patent/KR102436885B1/ko active Active
- 2014-05-26 PT PT147281315T patent/PT3004077T/pt unknown
- 2014-05-26 RU RU2015150287A patent/RU2695524C2/ru active
- 2014-05-26 HU HUE14728131A patent/HUE046773T2/hu unknown
- 2014-05-26 WO PCT/EP2014/060790 patent/WO2014191338A1/en not_active Ceased
-
2015
- 2015-11-20 US US14/947,760 patent/US9695151B2/en active Active
-
2018
- 2018-10-03 JP JP2018188242A patent/JP6670906B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RS59739B1 (sr) | 2020-02-28 |
| BR112015028871A2 (pt) | 2017-07-25 |
| HRP20192275T1 (hr) | 2020-03-06 |
| CA2903180C (en) | 2022-03-15 |
| DK3004077T3 (da) | 2020-01-13 |
| MX2015015010A (es) | 2016-03-09 |
| SI3004077T1 (sl) | 2020-01-31 |
| JP6416229B2 (ja) | 2018-10-31 |
| RU2695524C2 (ru) | 2019-07-23 |
| WO2014191338A1 (en) | 2014-12-04 |
| TW201533037A (zh) | 2015-09-01 |
| US20160075687A1 (en) | 2016-03-17 |
| BR112015028871B1 (pt) | 2022-02-01 |
| CA2903180A1 (en) | 2014-12-04 |
| JP6670906B2 (ja) | 2020-03-25 |
| KR102436885B1 (ko) | 2022-08-26 |
| AR096424A1 (es) | 2015-12-30 |
| EP3004077A1 (en) | 2016-04-13 |
| HK1213564A1 (zh) | 2016-07-08 |
| JP2016520601A (ja) | 2016-07-14 |
| PT3004077T (pt) | 2019-12-19 |
| JP2019023212A (ja) | 2019-02-14 |
| CN105143204A (zh) | 2015-12-09 |
| LT3004077T (lt) | 2020-01-27 |
| KR20160012145A (ko) | 2016-02-02 |
| ES2763338T3 (es) | 2020-05-28 |
| CN105143204B (zh) | 2018-02-02 |
| PL3004077T3 (pl) | 2020-04-30 |
| RU2015150287A (ru) | 2017-06-28 |
| HUE046773T2 (hu) | 2020-03-30 |
| US9695151B2 (en) | 2017-07-04 |
| TWI651317B (zh) | 2019-02-21 |
| EP3004077B1 (en) | 2019-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12017500658B1 (en) | Spirodiamine derivatives as aldosterone synthase inhibitors | |
| MX2015001099A (es) | Nuevos derivados biciclicos de piridina. | |
| MY186165A (en) | New bicyclic dihydroquinoline-2-one derivatives | |
| PH12017501825A1 (en) | Bicyclic quinazolinone derivatives | |
| MY169043A (en) | New dihydroquinoline-2-one derivatives | |
| MX343225B (es) | Nuevos derivados de aril-benzocicloalquil-amida. | |
| PH12016501007A1 (en) | Substituted benzamides and methods of use thereof | |
| IN2015DN00960A (es) | ||
| PH12014502697B1 (en) | New diazaspirocycloalkane and azaspirocycloalkane | |
| UA112428C2 (uk) | Пестицидні композиції і пов'язані з ними способи | |
| MY169267A (en) | New aryl-quinoline derivatives | |
| MX366678B (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| UA117490C2 (uk) | Сполуки ізоіндоліну або ізохіноліну, спосіб їх одержання і фармацевтичні композиції, що їх містять | |
| MX370389B (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| MX2013005753A (es) | Nuevos derivados de biaril amida. | |
| GEAP201814266A (en) | Pyrazines modulators of gpr6 | |
| PH12018500668A1 (en) | Therapeutic compounds and methods of use thereof | |
| MX2015015058A (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| MX2015011005A (es) | Derivados de dihidorquinolin-2-ona para usarse como inhibidores de aldoesterona sintasa. | |
| MX2015009377A (es) | Compuestos radiomarcados. | |
| MX2016002762A (es) | Derivados de fenil-dihidropiridina como inhibidores de aldosterona sintasa. | |
| TH148774A (th) | อนุพันธ์ไบไซคลิค ไดไฮโดรควิโนลีน-2-โอนใหม่ | |
| TW201613947A (en) | Dinitrosyl iron complexes, uses thereof, and water splitting device using the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |