BRPI0815042A2 - Compostos de pirazol - Google Patents

Compostos de pirazol

Info

Publication number
BRPI0815042A2
BRPI0815042A2 BRPI0815042-7A2A BRPI0815042A BRPI0815042A2 BR PI0815042 A2 BRPI0815042 A2 BR PI0815042A2 BR PI0815042 A BRPI0815042 A BR PI0815042A BR PI0815042 A2 BRPI0815042 A2 BR PI0815042A2
Authority
BR
Brazil
Prior art keywords
pirazol
compounds
pirazol compounds
Prior art date
Application number
BRPI0815042-7A2A
Other languages
English (en)
Inventor
Jingrong Jean Cui
Judith Gail Deal
Danlin Gu
Chuangxing Guo
Mary Catherine Johnson
Robert Steven Kania
Susan Elizabeth Kephart
Maria Angelica Linton
Indrawan James Mcapline
Mason Alan Pairish
Cynthia Louise Palmer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US95323507P priority Critical
Priority to US8005408P priority
Application filed by Pfizer filed Critical Pfizer
Priority to PCT/IB2008/001952 priority patent/WO2009016460A2/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40122511&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0815042(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of BRPI0815042A2 publication Critical patent/BRPI0815042A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
BRPI0815042-7A2A 2007-08-01 2008-07-21 Compostos de pirazol BRPI0815042A2 (pt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US95323507P true 2007-08-01 2007-08-01
US8005408P true 2008-07-11 2008-07-11
PCT/IB2008/001952 WO2009016460A2 (en) 2007-08-01 2008-07-21 Pyrazole compounds and their use as raf inhibitors

Publications (1)

Publication Number Publication Date
BRPI0815042A2 true BRPI0815042A2 (pt) 2015-02-10

Family

ID=40122511

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815042-7A2A BRPI0815042A2 (pt) 2007-08-01 2008-07-21 Compostos de pirazol

Country Status (24)

Country Link
US (1) US7772246B2 (pt)
EP (1) EP2183243A2 (pt)
JP (1) JP4792126B2 (pt)
KR (1) KR20100038119A (pt)
CN (1) CN101815712A (pt)
AP (1) AP201005167A0 (pt)
AR (1) AR067759A1 (pt)
AU (1) AU2008281543A1 (pt)
BR (1) BRPI0815042A2 (pt)
CA (1) CA2695114A1 (pt)
CL (1) CL2008002255A1 (pt)
CO (1) CO6251265A2 (pt)
CR (1) CR11241A (pt)
DO (1) DOP2010000047A (pt)
EA (1) EA201000113A1 (pt)
EC (1) ECSP109922A (pt)
MA (1) MA31574B1 (pt)
PA (1) PA8791801A1 (pt)
PE (1) PE20090952A1 (pt)
SV (1) SV2010003472A (pt)
TN (1) TN2010000052A1 (pt)
TW (1) TW200911243A (pt)
UY (1) UY31260A1 (pt)
WO (1) WO2009016460A2 (pt)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005001A (es) * 2000-12-05 2003-09-05 Vertex Pharma INHIBITORS OF N-TERMINAL C-JUN CINASAS (JNK) AND OTHER PROTEIN KINES.
PT2455382T (pt) * 2005-12-13 2017-01-31 Incyte Holdings Corp PYRIDOLES [2,3-B] PYRIDINES AND PYRROLE [2,3-B] PYRIMIDINES SUBSTITUTED BY HETEROARYLO AS JANUS KINASES INHIBITORS
AU2008266183B2 (en) 2007-06-13 2013-09-12 Incyte Holdings Corporation Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
MX2011001019A (es) 2008-08-05 2011-03-25 Daiichi Sankyo Co Ltd DERIVATIVES OF IMIDAZOPIRIDIN-2-ONA.
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
EP2370424A1 (en) 2008-11-10 2011-10-05 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
KR101745331B1 (ko) 2008-12-19 2017-06-09 버텍스 파마슈티칼스 인코포레이티드 Atr 키나제의 억제제로서 유용한 피라진 유도체
WO2010100127A1 (en) 2009-03-04 2010-09-10 Novartis Ag Disubstituted imidazole derivatives as modulators of raf kinase
JP6172939B2 (ja) 2009-05-22 2017-08-02 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation 3- [4- (7H-Pyrrolo [2,3-D] pyrimidin-4-yl) -1H-pyrazol-1-yl] octane- or heptane-nitrile as JAK inhibitors
MX2011012353A (es) * 2009-05-22 2011-12-14 Incyte Corp DERIVATIVES OF N- (HETERO) ARIL-PIRROLIDINA DE PIRAZOL-4-IL-PIRROLO [2, 3-D] PIRIMIDINES AND PIRROL-3-IL-PIRROLO [2,3-D] PYRIMIDINS AS INHIBITORS OF THE JANUS CINASE.
US8329724B2 (en) * 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
JO3002B1 (ar) 2009-08-28 2016-09-05 Irm Llc Protein kinase inhibitors
WO2011028685A1 (en) 2009-09-01 2011-03-10 Incyte Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
KR101481872B1 (ko) * 2009-09-10 2015-01-12 에프. 호프만-라 로슈 아게 Jak의 억제제
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
KR20200124776A (ko) 2010-03-10 2020-11-03 인사이트 홀딩스 코포레이션 Jak1 저해제로서의 피페리딘­4­일 아제티딘 유도체
WO2011143399A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP5836367B2 (ja) 2010-05-12 2015-12-24 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼ阻害剤として有用な化合物
US9062008B2 (en) 2010-05-12 2015-06-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
CA2798760A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as inhibitors of atr kinase
JP2013526539A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼ阻害剤として有用なピラジン
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼ阻害剤として有用な化合物
SG10201503983QA (en) 2010-05-21 2015-06-29 Incyte Corp Topical Formulation for a JAK Inhibitor
CA2803802A1 (en) 2010-06-23 2011-12-29 Vertex Pharmaceuticals Incorporated Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
US8779150B2 (en) * 2010-07-21 2014-07-15 Hoffmann-La Roche Inc. Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
TW201249845A (en) 2010-11-19 2012-12-16 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
WO2012135631A1 (en) 2011-03-30 2012-10-04 Arrien Pharmaeuticals Llc Substituted 5-(pyrazin-2-yl)-1h-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
AU2012240030A1 (en) 2011-04-05 2013-10-24 Vertex Pharmaceuticals Incorporated Aminopyrazine compounds useful as inhibitors of TRA kinase
ES2560611T3 (es) 2011-06-20 2016-02-22 Incyte Holdings Corporation Phenyl azetidinyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
US9096602B2 (en) 2011-06-22 2015-08-04 Vertex Pharmaceuticals Incorporated Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
JP2014520161A (ja) 2011-06-22 2014-08-21 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼ阻害剤として有用な化合物
WO2012178125A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為jak抑制劑之環己基氮雜環丁烷衍生物
IN2014DN02177A (pt) 2011-09-07 2015-05-15 Incyte Corp
NZ719122A (en) 2011-09-30 2017-12-22 Vertex Pharma Processes for making compounds useful as inhibitors of atr kinase
EP3733185A1 (en) 2011-09-30 2020-11-04 Vertex Pharmaceuticals Incorporated Treating non-small cell lung cancer with atr inhibitors
EP2751088B1 (en) 2011-09-30 2016-04-13 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013049720A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013049722A1 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013071094A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
EP2776420A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
JP2015502925A (ja) 2011-11-09 2015-01-29 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated Atrキナーゼの阻害剤として有用なピラジン化合物
EP2776422A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013071088A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
CN103945831A (zh) 2011-11-23 2014-07-23 诺华股份有限公司 医药制剂
CN103159736B (zh) * 2011-12-10 2015-05-13 通化济达医药有限公司 取代的吡唑激酶抑制剂
DK2833973T3 (da) 2012-04-05 2018-01-02 Vertex Pharma Compounds useful as ATR kinase inhibitors and combination therapies thereof
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
EP2904406B1 (en) 2012-10-04 2018-03-21 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
WO2014062604A1 (en) 2012-10-16 2014-04-24 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
MX2015005947A (es) 2012-11-15 2015-09-08 Incyte Corp DOSAGE FORMS OF SUSTAINED RUXOLITINIB LIBERATION.
PL2941432T3 (pl) 2012-12-07 2018-09-28 Vertex Pharmaceuticals Incorporated 2-Amino-6-fluoro-N- (5-fluoro-4- (4- (4- (oxetan-3-yl) piperazine-1-carbonyl) piperidin-1-yl) pyridin-3-yl) pirazoto [ 1.5alph] pyrimidine-3-carboxamide as an ATR kinase inhibitor
WO2014111496A1 (en) * 2013-01-18 2014-07-24 F. Hoffmann-La Roche Ag 3-substituted pyrazoles and use as dlk inhibitors
PL2958913T3 (pl) 2013-02-20 2019-03-29 Lg Chem, Ltd. AGONISTS OF THE SFINGOSINE-1-PHOSPHATE RECEPTOR, METHODS OF THEIR PREPARATION AND INCLUDING THEM AS AN ACTIVE AGENT PHARMACEUTICAL COMPOSITIONS
WO2014134341A1 (en) 2013-03-01 2014-09-04 Amgen Inc. Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
KR20150140287A (ko) 2013-03-06 2015-12-15 인사이트 코포레이션 Jak 저해제를 제조하기 위한 방법 및 중간생성물
EP2970286A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
AU2014233437B2 (en) * 2013-03-15 2018-07-26 Plexxikon Inc. Heterocyclic compounds and uses thereof
CA2920108A1 (en) 2013-08-07 2015-02-12 Incyte Corporation Sustained release dosage forms for a jak1 inhibitor
CN103626767A (zh) * 2013-12-04 2014-03-12 上海药明康德新药开发有限公司 区域选择性的氮杂吲哚及其合成方法
PL3077397T3 (pl) 2013-12-06 2020-04-30 Vertex Pharmaceuticals Inc. COMPOUND 2-AMINO-6-FLUORO-N- [5-FLUORO-PYRIDINE-3-YLO] PYRAZOLO [1,5-A] PIRIMIDINO-3-CARBOXAMIDE USEFUL AS AN ATR KINASE INHIBITOR, ITS MANUFACTURING AND RABBITING DERIVATIVES
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
BR112016028273A2 (pt) 2014-06-05 2017-08-22 Vertex Pharma radiolabelled derivatives of 2-amino-6-fluoro-n- [5-fluoro-pyridin-3-yl] -pyrazol [1,5-a] pyrimidin-3-carboxamide compound useful as atrinase inhibitor, preparation of said compound and different solid forms thereof
WO2016022724A1 (en) 2014-08-08 2016-02-11 Amgen Inc. Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
CN105777743A (zh) * 2014-12-19 2016-07-20 奥浦顿(上海)医药科技有限公司 一种吡唑并[3,4-b]吡啶类化合物中间体的制备方法和应用
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
EP3694855A1 (en) 2017-10-13 2020-08-19 Plexxikon Inc. Solid forms of a compound for modulating kinases
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
CN109575019B (zh) * 2018-12-26 2020-04-14 苏州闻智生物科技有限公司 一种5-溴-7-氮杂吲哚的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2306108A (en) 1995-10-13 1997-04-30 Merck & Co Inc Treatment of Raf-mediated cancers with imidazole derivatives
US6514977B1 (en) * 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
AT296820T (de) * 1999-06-03 2005-06-15 Teikoku Hormone Mfg Co Ltd Substituierte pyrazol-derivate
AU7922100A (en) 1999-10-25 2001-05-08 Basf Aktiengesellschaft Agrochemical compositions containing pyrazoles as the active agents and use of said compositions as plant protection agents with a fungicidal action
JP2004521901A (ja) * 2001-02-02 2004-07-22 グラクソ グループ リミテッドGlaxo Group Limited Tgf阻害剤としてのピラゾール
JP2004521915A (ja) * 2001-02-02 2004-07-22 グラクソ グループ リミテッドGlaxo Group Limited Tgf過剰発現に対するピラゾール誘導体
CA2446864C (en) * 2001-05-16 2011-02-15 Vertex Pharmaceuticals Incorporated Inhibitors of src and other protein kinases
JP4399265B2 (ja) * 2001-12-21 2010-01-13 ヴァーナリス(ケンブリッジ)リミテッドVernalis(Cambridge)Limited 3,4−ジアリールピラゾール、および癌の治療におけるそれらの使用
AR040442A1 (es) * 2002-06-05 2005-04-06 Pharmacia Corp Derivados de pirazol como inhibidores de la quinasa p38
GB0215844D0 (en) * 2002-07-09 2002-08-14 Novartis Ag Organic compounds
BR0314302A (pt) * 2002-09-18 2005-07-05 Pfizer Producs Inc Compostos de pirazol como inibidores do fator de crescimento trnasformante (tgf)
CL2004000234A1 (es) * 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
US8178672B2 (en) * 2004-10-19 2012-05-15 Arqule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase
PT1841757E (pt) * 2005-01-07 2010-08-31 Pfizer Prod Inc Compostos de quinolina heteroaromáticos e respectiva utilização como inibidores de pde10
CA2643066A1 (en) 2006-03-16 2007-09-20 Pfizer Products Inc. Pyrazole compounds
EP2013218A2 (en) * 2006-04-17 2009-01-14 Arqule, Inc. Raf inhibitors and their uses

Also Published As

Publication number Publication date
ECSP109922A (es) 2010-03-31
UY31260A1 (es) 2009-03-02
WO2009016460A3 (en) 2009-03-26
SV2010003472A (es) 2011-03-23
AR067759A1 (es) 2009-10-21
TN2010000052A1 (fr) 2011-09-26
CR11241A (es) 2010-04-27
AP201005167A0 (en) 2010-02-28
PA8791801A1 (es) 2009-03-31
PE20090952A1 (es) 2009-07-19
EP2183243A2 (en) 2010-05-12
WO2009016460A8 (en) 2009-10-15
CL2008002255A1 (es) 2009-04-17
JP4792126B2 (ja) 2011-10-12
CA2695114A1 (en) 2009-02-05
MA31574B1 (fr) 2010-08-02
CO6251265A2 (es) 2011-02-21
KR20100038119A (ko) 2010-04-12
AU2008281543A1 (en) 2009-02-05
WO2009016460A2 (en) 2009-02-05
JP2010535189A (ja) 2010-11-18
US7772246B2 (en) 2010-08-10
EA201000113A1 (ru) 2010-08-30
TW200911243A (en) 2009-03-16
CN101815712A (zh) 2010-08-25
DOP2010000047A (es) 2010-04-15
US20090221608A1 (en) 2009-09-03

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