ATE324446T1 - Mutante formen von etxb und ctxb und ihre verwendung als träger - Google Patents

Mutante formen von etxb und ctxb und ihre verwendung als träger

Info

Publication number
ATE324446T1
ATE324446T1 AT02740892T AT02740892T ATE324446T1 AT E324446 T1 ATE324446 T1 AT E324446T1 AT 02740892 T AT02740892 T AT 02740892T AT 02740892 T AT02740892 T AT 02740892T AT E324446 T1 ATE324446 T1 AT E324446T1
Authority
AT
Austria
Prior art keywords
etxb
ctxb
carriers
mutant
mutant forms
Prior art date
Application number
AT02740892T
Other languages
English (en)
Inventor
Timothy Raymond Hirst
Original Assignee
Timothy R Hirst Consulting Pty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Timothy R Hirst Consulting Pty filed Critical Timothy R Hirst Consulting Pty
Application granted granted Critical
Publication of ATE324446T1 publication Critical patent/ATE324446T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02740892T 2001-06-22 2002-06-20 Mutante formen von etxb und ctxb und ihre verwendung als träger ATE324446T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0115382.4A GB0115382D0 (en) 2001-06-22 2001-06-22 Mutant

Publications (1)

Publication Number Publication Date
ATE324446T1 true ATE324446T1 (de) 2006-05-15

Family

ID=9917219

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740892T ATE324446T1 (de) 2001-06-22 2002-06-20 Mutante formen von etxb und ctxb und ihre verwendung als träger

Country Status (7)

Country Link
US (2) US7422752B2 (de)
EP (1) EP1402039B1 (de)
AT (1) ATE324446T1 (de)
DE (1) DE60210970T2 (de)
ES (1) ES2260445T3 (de)
GB (1) GB0115382D0 (de)
WO (1) WO2003000899A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006041983A2 (en) * 2004-10-06 2006-04-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Acting For The Louisiana State University Health Sciences Center In New Orleans Channel current cheminformatics and bioengineering methods for immunological screening, single-molecule analysis, and single-molecular-interaction analysis
US9120111B2 (en) 2012-02-24 2015-09-01 Rain Bird Corporation Arc adjustable rotary sprinkler having full-circle operation and automatic matched precipitation
US9156043B2 (en) 2012-07-13 2015-10-13 Rain Bird Corporation Arc adjustable rotary sprinkler with automatic matched precipitation
MX2015012461A (es) 2013-03-15 2016-08-08 Bioven 3 Ltd Proteinas sintéticas autoensamblables.
WO2018111018A2 (ko) * 2016-12-16 2018-06-21 한양대학교 에리카산학협력단 플라스미드 기반의 ｃｔｘ 파지 복제시스템 및 ｃｔｘ 파지에 감염되고 콜레라 독소를 생산할 수 있는 비브리오 콜레라 균주
US11136358B2 (en) 2016-12-16 2021-10-05 Industry-University Cooperation Foundation Hanyang University Erica Campus Plasmid-based CTX phage replication system and vibrio cholerae strain that can be infected by CTX phage and can be used for cholera toxin production
CN113388008B (zh) * 2021-06-25 2023-04-28 太原师范学院 一种细胞内质网靶向的自释放型蛋白运输载体lca2及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513733D0 (en) * 1995-07-05 1995-09-06 Univ Bristol Therapeutic agents
EP1075274A2 (de) * 1998-05-08 2001-02-14 University Of Bristol Immunomodulatoren für impstoffen
GB9819484D0 (en) * 1998-09-07 1998-10-28 Univ Bristol Therapeutic agents
WO2001027144A2 (en) * 1999-10-08 2001-04-19 Active Biotech Ab Ab5 toxin b subunit mutants with altered chemical conjugation characteristics

Also Published As

Publication number Publication date
EP1402039B1 (de) 2006-04-26
GB0115382D0 (en) 2001-08-15
US7422752B2 (en) 2008-09-09
ES2260445T3 (es) 2006-11-01
WO2003000899A1 (en) 2003-01-03
US20080305125A1 (en) 2008-12-11
DE60210970D1 (de) 2006-06-01
US20060002905A1 (en) 2006-01-05
DE60210970T2 (de) 2007-01-04
EP1402039A1 (de) 2004-03-31
US8425917B2 (en) 2013-04-23

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Legal Events

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