ATE420097T1 - Substituierte sapogenine und ihre verwendung - Google Patents

Substituierte sapogenine und ihre verwendung

Info

Publication number
ATE420097T1
ATE420097T1 AT01900185T AT01900185T ATE420097T1 AT E420097 T1 ATE420097 T1 AT E420097T1 AT 01900185 T AT01900185 T AT 01900185T AT 01900185 T AT01900185 T AT 01900185T AT E420097 T1 ATE420097 T1 AT E420097T1
Authority
AT
Austria
Prior art keywords
substituted sapogenins
sapogenins
treatment
substituted
disclosed
Prior art date
Application number
AT01900185T
Other languages
English (en)
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Application granted granted Critical
Publication of ATE420097T1 publication Critical patent/ATE420097T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Catalysts (AREA)
AT01900185T 2000-01-06 2001-01-08 Substituierte sapogenine und ihre verwendung ATE420097T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0000228.7A GB0000228D0 (en) 2000-01-06 2000-01-06 Fluoro substituted sapogenins and their use

Publications (1)

Publication Number Publication Date
ATE420097T1 true ATE420097T1 (de) 2009-01-15

Family

ID=9883260

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01900185T ATE420097T1 (de) 2000-01-06 2001-01-08 Substituierte sapogenine und ihre verwendung

Country Status (15)

Country Link
US (3) US20030158161A1 (de)
EP (1) EP1246835B9 (de)
JP (1) JP2003519624A (de)
CN (1) CN1215080C (de)
AT (1) ATE420097T1 (de)
AU (1) AU2386201A (de)
BR (1) BR0107691A (de)
CA (1) CA2395100C (de)
DE (1) DE60137307D1 (de)
ES (1) ES2323671T3 (de)
GB (1) GB0000228D0 (de)
HK (1) HK1046912B (de)
MX (1) MXPA02006720A (de)
PT (1) PT1246835E (de)
WO (1) WO2001049703A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
EP1490071B1 (de) * 2002-03-27 2009-03-04 Phytopharm Plc Therapeutische verwendung von sapogeninen
DE60326437D1 (de) * 2002-03-27 2009-04-16 Phytopharm Plc Godmanchester Therapeutische verwendung von sapogeninen
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
ATE424211T1 (de) * 2002-03-27 2009-03-15 Phytopharm Plc Therapeutische verwendung von sapogeninen
MXPA05004494A (es) 2002-10-28 2005-07-26 Phytopharm Plc Reduccion estereoespecifica de sapogen-3-onas.
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
AU2010207597A1 (en) 2009-01-24 2011-08-18 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
JP2013543482A (ja) 2010-07-20 2013-12-05 ファイトファーム ピーエルシー Ｌ−ドーパ、ドーパミン作動薬及び／又はドーパミン賦活剤により誘発される疾患の処置
AU2012304412A1 (en) 2011-09-08 2014-03-27 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2013149580A1 (en) 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
PT2968369T (pt) 2013-03-13 2018-12-05 Sage Therapeutics Inc Esteroides neuroativos e métodos para o seu uso
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN106905407B (zh) * 2015-01-27 2019-08-13 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
EP3319610A4 (de) 2015-07-06 2019-03-06 Sage Therapeutics, Inc. Oxysterole und verfahren zur verwendung davon
CN113292623A (zh) 2015-07-06 2021-08-24 萨奇治疗股份有限公司 孕甾醇及其使用方法
PT3319612T (pt) 2015-07-06 2021-08-24 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
KR101777920B1 (ko) * 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
ES2921010T3 (es) 2016-04-01 2022-08-16 Sage Therapeutics Inc Oxisteroles y procedimientos de uso de los mismos
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
ES2884071T3 (es) 2016-07-07 2021-12-10 Sage Therapeutics Inc 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
BR112019008032A2 (pt) 2016-10-18 2019-09-03 Sage Therapeutics, Inc. oxiesteróis e métodos de uso dos mesmos
EP4105223B1 (de) 2016-10-18 2025-04-30 Sage Therapeutics, Inc. Oxysterole und verfahren zur verwendung davon
CN108117580A (zh) * 2016-11-30 2018-06-05 沈阳药科大学 菝葜皂苷元衍生物及其制备方法和用途
CN108264535A (zh) 2016-12-30 2018-07-10 中国科学院上海药物研究所 一种抗抑郁化合物及其制备方法和应用
CN109206472A (zh) * 2018-09-27 2019-01-15 华东理工大学 薯蓣皂苷元衍生物、其药物组合物及其应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695287A (en) * 1952-01-08 1954-11-23 Merck & Co Inc Isoallospirostane derivatives and process
FR1405214A (fr) * 1962-06-21 1965-07-09 Rhone Poulenc Sa Nouveaux stéroïdes de la série du prégnane et leur procédé de préparation
ES359406A1 (es) * 1967-10-23 1970-06-01 Erba Carlo Spa Procedimiento para la preparacion de nuevos derivados de (25r)-3 beta-amino-5alfa, 22alfa-espirostano.
BE794362A (fr) * 1972-01-22 1973-07-23 Merck Patent Gmbh Sulfates hydrosolubles de sterine
US3929769A (en) * 1972-05-19 1975-12-30 Ciba Geigy Corp Process for the manufacture of steroid epoxides
CA985172A (en) * 1972-10-06 1976-03-09 Dushan M. Dvornik Compositions and methods for reducing blood cholesterol
DE2416978A1 (de) * 1974-04-08 1975-10-09 Degussa Arzneimittel mit dem hauptsapogenin der helleborus-arten als wirkstoff
LU81256A1 (fr) * 1979-05-15 1980-12-16 Oreal Composition cosmetique capillaire notamment pour le lavage et/ou le demelage des cheveux,a base d'un extrait de plantes contenant des saponosides
JPS5855500A (ja) * 1981-09-25 1983-04-01 Tokiwa Yakuhin Kogyo Kk １６−デヒドロプレグネノロンの製造法
US4602003A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
US4562250A (en) * 1982-09-13 1985-12-31 Regents Of The University Of Minnesota Steroidal glycosides produced by Yucca tissue culture
US4546097A (en) * 1983-11-04 1985-10-08 The United States Of America As Represented By The Department Of Health And Human Services Saponin-based polyether polyols, pharmaceutical compositions and a method of using same
US4680289A (en) * 1985-06-05 1987-07-14 Progenics, Inc. Treatment of obesity and diabetes using sapogenins
US5017562A (en) * 1987-02-11 1991-05-21 Regents Of The University Of Minnesota Crystalline saponin-containing complex
DE3838716A1 (de) * 1988-11-15 1990-05-17 Kanoldt Arzneimittel Gmbh Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie
EP0515386B1 (de) * 1990-01-18 1999-12-22 Cura Nominees Pty Ltd Glykoalkaloide
US5252729A (en) * 1991-10-23 1993-10-12 Schering Corporation Extraction of compounds from plant materials using supercritical fluids
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
BR9306619A (pt) * 1992-06-26 1998-12-08 Pfizer Glicosídeos esteroidais para o tratamento da hipercolesterolemia
DE4303214A1 (de) * 1993-02-04 1994-08-11 Wolfgang Marks Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
BR9406332A (pt) * 1993-04-28 1995-12-26 Pfizer Mono-hidrato cristalino de espirostanil-glicosidal
CN1033754C (zh) * 1993-05-31 1997-01-08 上海第二医科大学 知母皂甙元作为制备β肾上腺素和M胆碱受体双向调节药的用途及其制法
US5589182A (en) * 1993-12-06 1996-12-31 Tashiro; Renki Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression
AU7948494A (en) * 1993-12-28 1995-07-17 Pfizer Inc. Steroidal glycosides
EP0737202A1 (de) * 1993-12-28 1996-10-16 Pfizer Inc. Hypocholesterolemische mittel
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
SI9520092A (en) * 1994-08-30 1997-12-31 Pfizer Spirostanyl glycosidal crystals
EP0782451A1 (de) * 1994-09-20 1997-07-09 Pfizer Inc. Kombinationen eines hemmers der cholesterinabsorption und eines hemmers der cholesterinsynthese
US6150336A (en) * 1995-05-29 2000-11-21 Pfizer Inc. Steroidal glycosides
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US6130232A (en) * 1995-10-13 2000-10-10 Banyu Pharmaceutical Coaltd Substituted piperidine derivatives as muscarinic M3 receptor antagonists
US5726179A (en) * 1996-04-01 1998-03-10 The University Of Toledo Muscarinic agonists
US5962445A (en) * 1996-05-09 1999-10-05 Amrad Operations Pty Ltd. Treatment of asthma and airway diseases
US5804239A (en) * 1996-07-26 1998-09-08 Nouveau Technologies, Inc. Method and composition for food flavoring
CN1131237C (zh) * 1997-09-26 2003-12-17 中国人民解放军军事医学科学院放射医学研究所 甾体皂甙防治老年性痴呆的用途及新的甾体皂甙
JP3873097B2 (ja) * 1997-11-06 2007-01-24 独立行政法人理化学研究所 抗肥満剤及び脂質代謝改善剤
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
TR200002774T2 (tr) * 1998-03-26 2001-06-21 Phytopharm Plc Alzheimer hastalığının tedavisi için steroit sapogenler ve bunların türevleri
US20030118673A1 (en) * 1998-03-26 2003-06-26 Zongqin Xia Smilagenin and anzurogenin-D for the treatment of alzheimer's disease
GB9905275D0 (en) * 1999-03-08 1999-04-28 Phytopharm Ltd Treatment of conditions associated with membrane-bound receptors and their function
GB2347676A (en) * 1999-03-08 2000-09-13 Phytopharm Plc Screening method
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US6687613B2 (en) * 2001-05-31 2004-02-03 Alpine Electronics, Inc. Display method and apparatus of navigation system
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
MXPA05004494A (es) * 2002-10-28 2005-07-26 Phytopharm Plc Reduccion estereoespecifica de sapogen-3-onas.

Also Published As

Publication number Publication date
EP1246835A2 (de) 2002-10-09
CA2395100C (en) 2010-12-21
HK1046912A1 (en) 2003-01-30
ES2323671T3 (es) 2009-07-23
WO2001049703A2 (en) 2001-07-12
CN1452630A (zh) 2003-10-29
HK1046912B (en) 2009-07-31
CA2395100A1 (en) 2001-07-12
AU2386201A (en) 2001-07-16
EP1246835B9 (de) 2010-02-17
PT1246835E (pt) 2009-04-15
JP2003519624A (ja) 2003-06-24
US20080207576A1 (en) 2008-08-28
BR0107691A (pt) 2005-03-22
EP1246835B1 (de) 2009-01-07
CN1215080C (zh) 2005-08-17
GB0000228D0 (en) 2000-03-01
DE60137307D1 (de) 2009-02-26
WO2001049703A3 (en) 2002-02-21
MXPA02006720A (es) 2002-09-30
US20030158161A1 (en) 2003-08-21
US20100087411A1 (en) 2010-04-08

Similar Documents

Publication Publication Date Title
DE60137307D1 (de) Substituierte sapogenine und ihre verwendung
ATE325808T1 (de) 5-beta-sapogenin und pseudosapogeninderivate und ihre verwendung zur behandlung von demenz
DE60238576D1 (de) Zusammensetzung zur Herstellung von Elektroden und Elektroden
ATE424211T1 (de) Therapeutische verwendung von sapogeninen
DE60319865D1 (de) Substituierte amin-derivate und deren verwendung zur behandlung von angionese-bedingten erkrankungen
NO20061736L (no) Krystallform av epotilon B
ATE314057T1 (de) Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit
NO20034056D0 (no) Proliferative sykdommer
DE60204548D1 (de) Mch antagonisten und deren verwendung zur behandlung von fettleibigkeit
ATE374204T1 (de) Thienopyrimidinedione und deren verwendung in der behandlung von autoimmunerkrankungen
DE60233265D1 (de) 5-sulfanyl-4h-1,2,4-triazolderivate und deren verwendung zur behandlung von somatostatine vermittelten krankheiten
ATE231872T1 (de) Thiazolopyrimidinderivate
DE60318839D1 (de) 2,6-chinolinyl- und 2,6-naphthylderivate und deren verwendungen zur behandlung von vla-4 bezogenen krankheiten
ATE325789T1 (de) Aminocyclohexylether-verbindungen und deren verwendung
CA2385410A1 (en) Sapogenin derivatives and their use in the treatment of cognitive dysfunction
DE602004017332D1 (de) Neue kondensierte n-pyrazinyl-sulfonamide und deren verwendung bei der behandlung von chemokinvermittelten krankheiten
GB9923078D0 (en) Sapogenin derivatives and their use
DE50114605D1 (de) No-thien-2-yl-essigsaure-derivate und ihre verwendung zur behandlung von migraine bzw. schmerz
DE60027429D1 (de) Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien
ATE290857T1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
ATE443060T1 (de) Benzoägüchinolinderivate zur behandlung von glaucom und kurzsichtigkeit
DK1196442T3 (da) VGF-polypeptider og fremgangsmåder til behandling af VGF-relaterede lidelser
TR200200278T2 (tr) Kalsilitik bileşimler
NO20060420L (no) 2-aminobenzoylderivater
DE50113300D1 (de) Verwendung von erythropoietin sowie dessen derivate zur behandlung von schizophrenie und verwandten psychosen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1246835

Country of ref document: EP