ATE314057T1 - Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit - Google Patents

Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit

Info

Publication number
ATE314057T1
ATE314057T1 AT99913462T AT99913462T ATE314057T1 AT E314057 T1 ATE314057 T1 AT E314057T1 AT 99913462 T AT99913462 T AT 99913462T AT 99913462 T AT99913462 T AT 99913462T AT E314057 T1 ATE314057 T1 AT E314057T1
Authority
AT
Austria
Prior art keywords
treatment
anzrogenin
smilagenin
alzheimer
disease
Prior art date
Application number
AT99913462T
Other languages
English (en)
Inventor
Zongqin Xia
Yaer Hu
Ian Rubin
Jonathan Brostoff
Brian Whittle
Weijun Wang
Phil Gunning
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806513.9A external-priority patent/GB9806513D0/en
Priority claimed from GBGB9905275.5A external-priority patent/GB9905275D0/en
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Application granted granted Critical
Publication of ATE314057T1 publication Critical patent/ATE314057T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/944—Acetylcholine
AT99913462T 1998-03-26 1999-03-26 Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit ATE314057T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9806513.9A GB9806513D0 (en) 1998-03-26 1998-03-26 Membrane-bound receptors
GBGB9905275.5A GB9905275D0 (en) 1999-03-08 1999-03-08 Treatment of conditions associated with membrane-bound receptors and their function
PCT/GB1999/000960 WO1999048482A2 (en) 1998-03-26 1999-03-26 Smilagenin and anzurogenin-d for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
ATE314057T1 true ATE314057T1 (de) 2006-01-15

Family

ID=26313369

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99913453T ATE337788T1 (de) 1998-03-26 1999-03-26 Steroidale saponine zur behandlung der alzheimerischen krankheit
AT06017380T ATE507834T1 (de) 1998-03-26 1999-03-26 Sarsasapogenin und smilagenin zur behandlung kognitiver störungen
AT99913462T ATE314057T1 (de) 1998-03-26 1999-03-26 Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT99913453T ATE337788T1 (de) 1998-03-26 1999-03-26 Steroidale saponine zur behandlung der alzheimerischen krankheit
AT06017380T ATE507834T1 (de) 1998-03-26 1999-03-26 Sarsasapogenin und smilagenin zur behandlung kognitiver störungen

Country Status (28)

Country Link
US (2) US6812213B2 (de)
EP (3) EP1719512B1 (de)
JP (4) JP3768100B2 (de)
KR (6) KR20090009997A (de)
CN (3) CN1198622C (de)
AT (3) ATE337788T1 (de)
AU (2) AU3158199A (de)
BR (2) BR9909110A (de)
CA (2) CA2325634A1 (de)
CY (1) CY1105653T1 (de)
DE (3) DE69929177T2 (de)
DK (2) DK1719512T3 (de)
ES (2) ES2272060T3 (de)
GB (1) GB2335599B (de)
HK (3) HK1033742A1 (de)
HR (2) HRP20000637A2 (de)
HU (2) HUP0101693A3 (de)
ID (2) ID26781A (de)
IL (4) IL138663A0 (de)
IS (2) IS5637A (de)
MX (1) MXPA00009437A (de)
NO (4) NO20004803L (de)
NZ (1) NZ507355A (de)
PL (3) PL195897B1 (de)
PT (1) PT1066042E (de)
RU (1) RU2297228C2 (de)
TR (2) TR200002773T2 (de)
WO (2) WO1999048507A2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277978B1 (en) 1995-12-22 2001-08-21 University Of Utah Research Foundation KVLQT1—a long QT syndrome gene
GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
AU781810B2 (en) * 1998-03-26 2005-06-16 Phytopharm Plc. Steroidal sapogenins and their derivatives for treating Alzheimer's disease
US20030118673A1 (en) * 1998-03-26 2003-06-26 Zongqin Xia Smilagenin and anzurogenin-D for the treatment of alzheimer's disease
DE69929177T2 (de) * 1998-03-26 2006-08-24 Phytopharm Plc, Godmanchester Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit
GB2347676A (en) * 1999-03-08 2000-09-13 Phytopharm Plc Screening method
US20010024664A1 (en) * 1999-03-19 2001-09-27 Obukowicz Mark G. Selective COX-2 inhibition from edible plant extracts
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
PT1490071E (pt) * 2002-03-27 2009-05-25 Phytopharm Plc Métodos terapêuticos e utilizações de sapogeninas e seus derivados
ATE424211T1 (de) * 2002-03-27 2009-03-15 Phytopharm Plc Therapeutische verwendung von sapogeninen
CA2477787C (en) * 2002-03-27 2011-12-20 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
CN102727501A (zh) * 2002-03-27 2012-10-17 菲特法姆股份有限公司 皂角苷配基及其衍生物的用途
KR101092150B1 (ko) * 2002-10-28 2011-12-12 파이토팜 피엘씨 사포겐-3-온의 입체특이적 환원
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0409567D0 (en) * 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
JP2008516972A (ja) * 2004-10-14 2008-05-22 ジョージタウン ユニバーシティー 神経保護作用を有するスピロステノールの薬学的組成物
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
KR100779179B1 (ko) * 2006-05-19 2007-11-28 충북대학교 산학협력단 토복령의 메탄올 추출물을 함유하는 뇌신경 보호 또는퇴행성뇌질환 예방 또는 치료제
JP2009256243A (ja) * 2008-04-17 2009-11-05 Noevir Co Ltd 保湿剤、抗老化剤、抗酸化剤、皮膚外用剤及び機能性経口組成物
WO2009153800A1 (en) 2008-06-17 2009-12-23 Pawan Kumar Goel A novel process for extraction of furostanolic saponins from fenugreek seeds
KR101027384B1 (ko) * 2009-06-29 2011-04-11 에이디엠이십일 주식회사 플랫와이퍼블레이드와 와이퍼아암의 연결장치
AU2010207597A1 (en) 2009-01-24 2011-08-18 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
US20130210786A1 (en) * 2010-07-20 2013-08-15 Patrick Alexander Howson Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
TWI422378B (zh) * 2010-11-18 2014-01-11 Univ Chung Shan Medical 使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷
CN102389438A (zh) * 2011-06-30 2012-03-28 北京师范大学 黄芪甲苷的应用
EP2946792A4 (de) * 2013-01-21 2016-09-28 Resilio Company Ltd Therapeutisches mittel und therapieverfahren mit 1,25d3-marrs für neurologische erkrankungen wie morbus alzheimer
KR101777920B1 (ko) * 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
CN105168785A (zh) * 2015-10-08 2015-12-23 湖北民族学院 一种治疗阿尔茨海默病的中药制剂及制备方法
EP3572085A1 (de) * 2018-05-25 2019-11-27 Neuro-Sys Synergistische kombinationszusammensetzung mit einem steroidalen saponin, einer ersten polyphenolverbindung und gegebenenfalls einer zweiten polyphenolverbindung
CN108514603B (zh) * 2018-06-28 2021-12-28 佳木斯大学 一种治疗强直型帕金森病的中药组合物及其制备方法
KR102028730B1 (ko) 2019-05-22 2019-10-04 (주)클래시스 집속초음파 기술을 이용한 지모 추출물의 제조방법 및 이로부터 수득된 지모 추출물
CN110859849A (zh) * 2019-12-11 2020-03-06 大连医科大学 薯蓣皂苷在制备帕金森病保护药物中的应用
US11788574B2 (en) 2021-08-13 2023-10-17 Rimgard Sweden AB Anti-theft locking bolt assembly

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794362A (fr) * 1972-01-22 1973-07-23 Merck Patent Gmbh Sulfates hydrosolubles de sterine
US3929769A (en) * 1972-05-19 1975-12-30 Ciba Geigy Corp Process for the manufacture of steroid epoxides
CA985172A (en) 1972-10-06 1976-03-09 Dushan M. Dvornik Compositions and methods for reducing blood cholesterol
DE2416978A1 (de) * 1974-04-08 1975-10-09 Degussa Arzneimittel mit dem hauptsapogenin der helleborus-arten als wirkstoff
LU81256A1 (fr) 1979-05-15 1980-12-16 Oreal Composition cosmetique capillaire notamment pour le lavage et/ou le demelage des cheveux,a base d'un extrait de plantes contenant des saponosides
JPS5855500A (ja) * 1981-09-25 1983-04-01 Tokiwa Yakuhin Kogyo Kk １６−デヒドロプレグネノロンの製造法
US4602003A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) * 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
US4562250A (en) * 1982-09-13 1985-12-31 Regents Of The University Of Minnesota Steroidal glycosides produced by Yucca tissue culture
US4546097A (en) * 1983-11-04 1985-10-08 The United States Of America As Represented By The Department Of Health And Human Services Saponin-based polyether polyols, pharmaceutical compositions and a method of using same
US4680289A (en) 1985-06-05 1987-07-14 Progenics, Inc. Treatment of obesity and diabetes using sapogenins
US5017562A (en) 1987-02-11 1991-05-21 Regents Of The University Of Minnesota Crystalline saponin-containing complex
DE3838716A1 (de) * 1988-11-15 1990-05-17 Kanoldt Arzneimittel Gmbh Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie
SG50585A1 (en) * 1990-01-18 1998-07-20 Cura Nominees Pty Ltd Glycoalkaloids
US5252729A (en) * 1991-10-23 1993-10-12 Schering Corporation Extraction of compounds from plant materials using supercritical fluids
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
WO1994000480A1 (en) * 1992-06-26 1994-01-06 Pfizer Inc. Steroidal glycosides for treating hypercholesterolemia
DE4303214A1 (de) * 1993-02-04 1994-08-11 Wolfgang Marks Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
AU6274394A (en) * 1993-02-23 1994-09-14 Pharmakon Usa, Inc. Therapeutic herbal composition
CN1092992A (zh) * 1993-03-29 1994-10-05 中国科学院沈阳应用生态研究所 提高脑功能的药物及其制备方法
CN1052636C (zh) * 1993-03-29 2000-05-24 中国科学院沈阳应用生态研究所 文冠果子的醇提取物在制备治疗智力低下的药物中的应用
CZ280195A3 (en) * 1993-04-28 1996-02-14 Pfizer Crystalline spirostanyl glycoside, monohydrate thereof, pharmaceutical composition based thereon and process for preparing crystalline steroidal glycoside
CN1033754C (zh) * 1993-05-31 1997-01-08 上海第二医科大学 知母皂甙元作为制备β肾上腺素和M胆碱受体双向调节药的用途及其制法
US5589182A (en) * 1993-12-06 1996-12-31 Tashiro; Renki Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression
AU7948494A (en) * 1993-12-28 1995-07-17 Pfizer Inc. Steroidal glycosides
EP0737202A1 (de) * 1993-12-28 1996-10-16 Pfizer Inc. Hypocholesterolemische mittel
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
PL318937A1 (en) * 1994-08-30 1997-07-21 Pfizer Spirostanyloglycoside crystals
CA2200436A1 (en) * 1994-09-20 1996-04-04 Pfizer Inc. Combination therapy for hypercholesterolemia
US6150336A (en) * 1995-05-29 2000-11-21 Pfizer Inc. Steroidal glycosides
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5804239A (en) 1996-07-26 1998-09-08 Nouveau Technologies, Inc. Method and composition for food flavoring
US6939570B1 (en) * 1997-05-15 2005-09-06 University Of Washington Composition and methods for treating Alzheimer's disease and other amyloidoses
EP1006802A4 (de) * 1997-08-28 2004-01-14 Cv Technologies Inc Chemische und pharmakologische standardisierung von pflanzenextrakten
CN1131237C (zh) * 1997-09-26 2003-12-17 中国人民解放军军事医学科学院放射医学研究所 甾体皂甙防治老年性痴呆的用途及新的甾体皂甙
JP3873097B2 (ja) * 1997-11-06 2007-01-24 独立行政法人理化学研究所 抗肥満剤及び脂質代謝改善剤
GB9905275D0 (en) * 1999-03-08 1999-04-28 Phytopharm Ltd Treatment of conditions associated with membrane-bound receptors and their function
DE69929177T2 (de) * 1998-03-26 2006-08-24 Phytopharm Plc, Godmanchester Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit
US6544566B1 (en) * 1999-04-23 2003-04-08 Protein Technologies International, Inc. Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol

Also Published As

Publication number Publication date
EP1719512A3 (de) 2007-04-11
ES2257042T3 (es) 2006-07-16
MXPA00009437A (es) 2002-05-06
KR100632052B1 (ko) 2006-10-04
HRP20000638A2 (en) 2001-04-30
IL138663A0 (en) 2001-10-31
DK1719512T3 (da) 2011-08-15
JP2004217666A (ja) 2004-08-05
BR9909109A (pt) 2000-12-12
EP1719512B1 (de) 2011-05-04
DK1066042T3 (da) 2006-12-18
PT1066042E (pt) 2006-12-29
US6812213B2 (en) 2004-11-02
NZ507355A (en) 2004-02-27
PL195897B1 (pl) 2007-11-30
AU3158199A (en) 1999-10-18
DE69933016D1 (de) 2006-10-12
NO20004804L (no) 2000-11-09
NO20083993L (no) 2000-09-11
GB9907100D0 (en) 1999-05-19
NO20085251L (no) 2000-11-09
IL138664A0 (en) 2001-10-31
EP1066033A1 (de) 2001-01-10
US20020193317A1 (en) 2002-12-19
KR20070007214A (ko) 2007-01-12
CN1302208A (zh) 2001-07-04
HUP0101693A3 (en) 2002-08-28
RU2297228C2 (ru) 2007-04-20
CN1198622C (zh) 2005-04-27
EP1066042B1 (de) 2006-08-30
CA2325633A1 (en) 1999-09-30
RU2004123463A (ru) 2006-01-27
HK1033903A1 (en) 2001-10-05
KR100713311B1 (ko) 2007-05-04
BR9909110A (pt) 2000-12-12
WO1999048482A2 (en) 1999-09-30
IS5638A (is) 2000-09-25
US20060182817A1 (en) 2006-08-17
ATE507834T1 (de) 2011-05-15
NO20004803L (no) 2000-11-27
GB2335599B (en) 2001-08-01
TR200002773T2 (tr) 2001-11-21
IS5637A (is) 2000-09-25
PL343508A1 (en) 2001-08-27
PL207723B1 (pl) 2011-01-31
CA2325633C (en) 2009-01-20
KR20090007505A (ko) 2009-01-16
CN100377714C (zh) 2008-04-02
ID26989A (id) 2001-02-22
DE69929177T2 (de) 2006-08-24
DE69933016T2 (de) 2007-03-29
ID26781A (id) 2001-02-08
NO20004803D0 (no) 2000-09-26
TR200002774T2 (tr) 2001-06-21
WO1999048482A3 (en) 2000-11-23
AU748138B2 (en) 2002-05-30
EP1066042A2 (de) 2001-01-10
JP2003524581A (ja) 2003-08-19
JP3768100B2 (ja) 2006-04-19
JP2002507572A (ja) 2002-03-12
KR20090009997A (ko) 2009-01-23
CN1209112C (zh) 2005-07-06
PL343423A1 (en) 2001-08-13
HUP0101693A2 (hu) 2001-12-28
KR20010042190A (ko) 2001-05-25
HK1091417A1 (en) 2007-01-19
ATE337788T1 (de) 2006-09-15
CA2325634A1 (en) 1999-09-30
NO20004804D0 (no) 2000-09-26
CN1679591A (zh) 2005-10-12
CY1105653T1 (el) 2010-12-22
EP1719512A2 (de) 2006-11-08
HUP0103654A2 (hu) 2002-02-28
PL380866A1 (pl) 2001-08-13
KR20010042205A (ko) 2001-05-25
KR20070117001A (ko) 2007-12-11
IL174991A0 (en) 2006-08-20
AU3157499A (en) 1999-10-18
GB2335599A (en) 1999-09-29
IL138663A (en) 2006-08-01
HK1033742A1 (en) 2001-09-21
JP2004224797A (ja) 2004-08-12
DE69929177D1 (de) 2006-02-02
WO1999048507A3 (en) 1999-11-25
ES2272060T3 (es) 2007-04-16
WO1999048507A2 (en) 1999-09-30
DE69943415D1 (de) 2011-06-16
KR101092050B1 (ko) 2011-12-12
EP1066033B1 (de) 2005-12-28
CN1301166A (zh) 2001-06-27
HRP20000637A2 (en) 2001-04-30

Similar Documents

Publication Publication Date Title
ATE314057T1 (de) Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit
HK1046912A1 (en) Substituted sapogenins and their use
IL180972A0 (en) 5-beta-sapogenin and psuedosapogenin derivatives and their use in the treatment of dementia
GB9923078D0 (en) Sapogenin derivatives and their use

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1066033

Country of ref document: EP