IS5637A - Steróíð sapógenín og afleiður þeirra til meðhöndlunar á Alzheimers-sjúkdómi - Google Patents

Steróíð sapógenín og afleiður þeirra til meðhöndlunar á Alzheimers-sjúkdómi

Info

Publication number
IS5637A
IS5637A IS5637A IS5637A IS5637A IS 5637 A IS5637 A IS 5637A IS 5637 A IS5637 A IS 5637A IS 5637 A IS5637 A IS 5637A IS 5637 A IS5637 A IS 5637A
Authority
IS
Iceland
Prior art keywords
treatment
alzheimer
disease
derivatives
sapogenins
Prior art date
Application number
IS5637A
Other languages
English (en)
Inventor
Xia Zongqin
Hu Yaer
Rubin Ian
Brostoff Jonathan
Whittle Brian
Wang Weijun
Gunning Phil
Original Assignee
Phytopharm Plc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806513.9A external-priority patent/GB9806513D0/en
Priority claimed from GBGB9905275.5A external-priority patent/GB9905275D0/en
Application filed by Phytopharm Plc. filed Critical Phytopharm Plc.
Publication of IS5637A publication Critical patent/IS5637A/is

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/944—Acetylcholine
IS5637A 1998-03-26 2000-09-25 Steróíð sapógenín og afleiður þeirra til meðhöndlunar á Alzheimers-sjúkdómi IS5637A (is)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9806513.9A GB9806513D0 (en) 1998-03-26 1998-03-26 Membrane-bound receptors
GBGB9905275.5A GB9905275D0 (en) 1999-03-08 1999-03-08 Treatment of conditions associated with membrane-bound receptors and their function
PCT/GB1999/000951 WO1999048507A2 (en) 1998-03-26 1999-03-26 Steroidal saponins for treating alzheimer's disease

Publications (1)

Publication Number Publication Date
IS5637A true IS5637A (is) 2000-09-25

Family

ID=26313369

Family Applications (2)

Application Number Title Priority Date Filing Date
IS5637A IS5637A (is) 1998-03-26 2000-09-25 Steróíð sapógenín og afleiður þeirra til meðhöndlunar á Alzheimers-sjúkdómi
IS5638A IS5638A (is) 1998-03-26 2000-09-25 Smílagenín og anzúrógenín-D til meðhöndlunar á Alzheimers-sjúkdómi

Family Applications After (1)

Application Number Title Priority Date Filing Date
IS5638A IS5638A (is) 1998-03-26 2000-09-25 Smílagenín og anzúrógenín-D til meðhöndlunar á Alzheimers-sjúkdómi

Country Status (28)

Country Link
US (2) US6812213B2 (is)
EP (3) EP1066042B1 (is)
JP (4) JP3768100B2 (is)
KR (6) KR20070007214A (is)
CN (3) CN1209112C (is)
AT (3) ATE314057T1 (is)
AU (2) AU748138B2 (is)
BR (2) BR9909109A (is)
CA (2) CA2325634A1 (is)
CY (1) CY1105653T1 (is)
DE (3) DE69929177T2 (is)
DK (2) DK1066042T3 (is)
ES (2) ES2272060T3 (is)
GB (1) GB2335599B (is)
HK (3) HK1033742A1 (is)
HR (2) HRP20000637A2 (is)
HU (2) HUP0103654A2 (is)
ID (2) ID26781A (is)
IL (4) IL138663A0 (is)
IS (2) IS5637A (is)
MX (1) MXPA00009437A (is)
NO (4) NO20004804L (is)
NZ (1) NZ507355A (is)
PL (3) PL343508A1 (is)
PT (1) PT1066042E (is)
RU (1) RU2297228C2 (is)
TR (2) TR200002774T2 (is)
WO (2) WO1999048482A2 (is)

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GB9923076D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
AU781810B2 (en) * 1998-03-26 2005-06-16 Phytopharm Plc. Steroidal sapogenins and their derivatives for treating Alzheimer's disease
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GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
CN1642558B (zh) * 2002-03-27 2012-05-30 菲特法姆股份有限公司 皂角苷配基及其衍生物的用途
EP2111864A3 (en) * 2002-03-27 2009-12-30 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
AU2003229877B8 (en) * 2002-03-27 2008-06-12 Phytopharm Plc Theraputic methods and uses of sapogenins and their derivatives
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JP2009256243A (ja) * 2008-04-17 2009-11-05 Noevir Co Ltd 保湿剤、抗老化剤、抗酸化剤、皮膚外用剤及び機能性経口組成物
WO2009153800A1 (en) 2008-06-17 2009-12-23 Pawan Kumar Goel A novel process for extraction of furostanolic saponins from fenugreek seeds
KR101027384B1 (ko) * 2009-06-29 2011-04-11 에이디엠이십일 주식회사 플랫와이퍼블레이드와 와이퍼아암의 연결장치
WO2010084356A1 (en) 2009-01-24 2010-07-29 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
WO2012010896A1 (en) * 2010-07-20 2012-01-26 Phytopharm Plc Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
TWI422378B (zh) * 2010-11-18 2014-01-11 Univ Chung Shan Medical 使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷
CN102389438A (zh) * 2011-06-30 2012-03-28 北京师范大学 黄芪甲苷的应用
WO2014112145A1 (ja) * 2013-01-21 2014-07-24 レジリオ株式会社 アルツハイマー病等を含む神経疾患の1,25d3-marrsが関与する治療薬及び治療法
KR101777920B1 (ko) * 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
CN105168785A (zh) * 2015-10-08 2015-12-23 湖北民族学院 一种治疗阿尔茨海默病的中药制剂及制备方法
EP3572085A1 (en) 2018-05-25 2019-11-27 Neuro-Sys Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and optionnaly a second polyphenolic compound
CN108514603B (zh) * 2018-06-28 2021-12-28 佳木斯大学 一种治疗强直型帕金森病的中药组合物及其制备方法
KR102028730B1 (ko) 2019-05-22 2019-10-04 (주)클래시스 집속초음파 기술을 이용한 지모 추출물의 제조방법 및 이로부터 수득된 지모 추출물
CN110859849A (zh) * 2019-12-11 2020-03-06 大连医科大学 薯蓣皂苷在制备帕金森病保护药物中的应用
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