EP1809298A4 - Neuroprotective spirostenol pharmaceutical compositions - Google Patents

Neuroprotective spirostenol pharmaceutical compositions

Info

Publication number
EP1809298A4
EP1809298A4 EP05812949A EP05812949A EP1809298A4 EP 1809298 A4 EP1809298 A4 EP 1809298A4 EP 05812949 A EP05812949 A EP 05812949A EP 05812949 A EP05812949 A EP 05812949A EP 1809298 A4 EP1809298 A4 EP 1809298A4
Authority
EP
European Patent Office
Prior art keywords
spirostenol
neuroprotective
pharmaceutical compositions
pharmaceutical
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05812949A
Other languages
German (de)
French (fr)
Other versions
EP1809298A2 (en
Inventor
Laurent Lecanu
Janet Greeson
Zhi-Xing Yao
Gary Teper
Vassilios Papadopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Samaritan Pharmaceuticals Inc
Original Assignee
Georgetown University
Samaritan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/031,538 external-priority patent/US20060009433A1/en
Application filed by Georgetown University, Samaritan Pharmaceuticals Inc filed Critical Georgetown University
Publication of EP1809298A2 publication Critical patent/EP1809298A2/en
Publication of EP1809298A4 publication Critical patent/EP1809298A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP05812949A 2004-10-14 2005-10-14 Neuroprotective spirostenol pharmaceutical compositions Withdrawn EP1809298A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61869604P 2004-10-14 2004-10-14
US11/031,538 US20060009433A1 (en) 2003-03-14 2005-01-07 Neuroprotective spirostenol pharmaceutical compositions
PCT/US2005/037023 WO2006044665A2 (en) 2004-10-14 2005-10-14 Neuroprotective spirostenol pharmaceutical compositions

Publications (2)

Publication Number Publication Date
EP1809298A2 EP1809298A2 (en) 2007-07-25
EP1809298A4 true EP1809298A4 (en) 2008-06-18

Family

ID=36203560

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05812949A Withdrawn EP1809298A4 (en) 2004-10-14 2005-10-14 Neuroprotective spirostenol pharmaceutical compositions

Country Status (5)

Country Link
EP (1) EP1809298A4 (en)
JP (1) JP2008516972A (en)
AU (1) AU2005295617A1 (en)
CA (1) CA2584333A1 (en)
WO (1) WO2006044665A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2603127A1 (en) * 2005-04-01 2006-10-12 Samaritan Pharmaceuticals, Inc. Use of spirostenols to treat mitochondrial disorders
GB0619860D0 (en) * 2006-10-06 2006-11-15 Birkeland Innovasjon As Treatment of insulin resistance and disorders associated therewith
US20170129915A1 (en) * 2014-04-25 2017-05-11 Resilio Company Limited Therapeutic agent for diseases associated with nerve axon dysfunction, including therapeutic agent for alzheimer's disease
WO2024024395A1 (en) * 2022-07-29 2024-02-01 国立大学法人富山大学 Pharmaceutical or food and beverage composition for prevention or treatment of optic nerve disorder

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011708A2 (en) * 2000-08-04 2002-02-14 Symphar S.A. Methods for inducing apolipoprotein e secretion
WO2003077869A2 (en) * 2002-03-15 2003-09-25 Samaritan Pharmaceuticals, Inc Neuroprotective spirostenol pharmaceutical compositions
WO2003086411A1 (en) * 2002-04-15 2003-10-23 Chengdu Di'ao Pharmaceutical Group Co., Ltd. Compounds and preparation methods of carboxylate and monoester succinate derivative of diosgenin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4303214A1 (en) * 1993-02-04 1994-08-11 Wolfgang Marks Treatment of diseases of viral, viroidal or oncogenic origin by steroid saponins or their aglycones
CN1131237C (en) * 1997-09-26 2003-12-17 中国人民解放军军事医学科学院放射医学研究所 Usage of steroi saponin for preventing and curing senile dementia and new steroid saponin
CN1198622C (en) * 1998-03-26 2005-04-27 植物药物公共有限公司 Steroidal saponins for treating alzheimer's disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011708A2 (en) * 2000-08-04 2002-02-14 Symphar S.A. Methods for inducing apolipoprotein e secretion
WO2003077869A2 (en) * 2002-03-15 2003-09-25 Samaritan Pharmaceuticals, Inc Neuroprotective spirostenol pharmaceutical compositions
WO2003086411A1 (en) * 2002-04-15 2003-10-23 Chengdu Di'ao Pharmaceutical Group Co., Ltd. Compounds and preparation methods of carboxylate and monoester succinate derivative of diosgenin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KOLDAMOVA R P, LEFTEROV I M, IKONOMOVIC M D, SKOKO J, LEFTEROV P I, ISANSKI B A, DEKOSKY S T, LAZO J S: "22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 15, 11 April 2003 (2003-04-11), pages 13244 - 13256, XP002476236 *
LECANU L ET AL: "Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity", STEROIDS, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 69, no. 1, January 2004 (2004-01-01), pages 1 - 16, XP004484607, ISSN: 0039-128X *
LIU ZHONGRONG ET AL: "Preparation of carboxylate and monoester succinate derivatives of diosgenin and their bioactivities for treating and preventing cerebrovascular and cardiovascular diseases", HCAPLUS, 23 October 2003 (2003-10-23), XP002391897 *
YAO Z-X ET AL: "22R-Hydroxycholesterol Protects Neuronal Cells from Beta-Amyloid-Induced Cytotoxicity by Binding to Beta-Amyloid Peptide", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 83, 2002, pages 1110 - 1119, XP003015166, ISSN: 0022-3042 *

Also Published As

Publication number Publication date
CA2584333A1 (en) 2006-04-27
EP1809298A2 (en) 2007-07-25
WO2006044665A3 (en) 2007-07-05
AU2005295617A1 (en) 2006-04-27
JP2008516972A (en) 2008-05-22
WO2006044665A2 (en) 2006-04-27

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Legal Events

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Effective date: 20070705

RIC1 Information provided on ipc code assigned before grant

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Ipc: A61K 31/58 20060101ALI20070801BHEP

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