DE60027429D1 - Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien - Google Patents
Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämienInfo
- Publication number
- DE60027429D1 DE60027429D1 DE60027429T DE60027429T DE60027429D1 DE 60027429 D1 DE60027429 D1 DE 60027429D1 DE 60027429 T DE60027429 T DE 60027429T DE 60027429 T DE60027429 T DE 60027429T DE 60027429 D1 DE60027429 D1 DE 60027429D1
- Authority
- DE
- Germany
- Prior art keywords
- dyslipidia
- dihydrobenzodiazepines
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9908714 | 1999-07-06 | ||
FR9908714A FR2796070B1 (fr) | 1999-07-06 | 1999-07-06 | Derives de benzodiazepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation |
PCT/EP2000/006230 WO2001002373A1 (fr) | 1999-07-06 | 2000-07-04 | Dihydrobenzodiazepines et leur utilisation dans le traitement de dyslipidemies |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60027429D1 true DE60027429D1 (de) | 2006-05-24 |
DE60027429T2 DE60027429T2 (de) | 2006-12-14 |
Family
ID=9547763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60027429T Expired - Lifetime DE60027429T2 (de) | 1999-07-06 | 2000-07-04 | Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien |
Country Status (22)
Country | Link |
---|---|
US (1) | US7323458B1 (de) |
EP (1) | EP1189890B1 (de) |
JP (1) | JP4699663B2 (de) |
KR (1) | KR20020022763A (de) |
CN (1) | CN1359377A (de) |
AR (1) | AR031071A1 (de) |
AT (1) | ATE323685T1 (de) |
AU (1) | AU767016B2 (de) |
BR (1) | BR0012169A (de) |
CA (1) | CA2378165C (de) |
CZ (1) | CZ20014604A3 (de) |
DE (1) | DE60027429T2 (de) |
ES (1) | ES2258975T3 (de) |
FR (1) | FR2796070B1 (de) |
HU (1) | HUP0201785A3 (de) |
MX (1) | MXPA01013457A (de) |
NO (1) | NO20020031L (de) |
PL (1) | PL352333A1 (de) |
RU (1) | RU2247115C2 (de) |
SK (1) | SK19142001A3 (de) |
WO (1) | WO2001002373A1 (de) |
ZA (1) | ZA200201008B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10142660A1 (de) | 2001-08-31 | 2003-03-20 | Aventis Pharma Gmbh | Verwendung von Derivaten von C2-substituierten Indan-1-ol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
US6677303B2 (en) * | 2001-04-30 | 2004-01-13 | Syn X Pharma | Biopolymer marker indicative of disease state having a molecular weight of 1097 daltons |
CA2446136C (en) * | 2001-05-03 | 2011-07-05 | Galileo Pharmaceuticals, Inc. | Pyruvate derivatives |
DE10142722A1 (de) * | 2001-08-31 | 2003-03-27 | Aventis Pharma Gmbh | C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE10142659A1 (de) | 2001-08-31 | 2003-03-20 | Aventis Pharma Gmbh | Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
DE10142668A1 (de) * | 2001-08-31 | 2003-03-20 | Aventis Pharma Gmbh | Verwendung von C2-substituierten Indan-1-on-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
DE10320732A1 (de) * | 2003-05-05 | 2004-12-09 | Friedrich-Schiller-Universität Jena Büro für Forschungstransfer | Neue schnell wirkende Anästhetika und Verfahren zu ihrer Herstellung |
RU2363696C2 (ru) * | 2003-07-10 | 2009-08-10 | Оси Фармасьютикалз, Инк. | Производные нафтилена как ингибиторы цитохрома р450 |
JP4679517B2 (ja) * | 2003-07-23 | 2011-04-27 | エグゼリクシス, インコーポレイテッド | 薬剤としてのアゼピン誘導体 |
ZA200603515B (en) * | 2003-10-08 | 2007-11-28 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
US7662844B2 (en) | 2004-07-12 | 2010-02-16 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome P450 inhibitors |
WO2006063294A2 (en) * | 2004-12-09 | 2006-06-15 | Kalypsys, Inc. | Novel inhibitors of histone deacetylase for the treatment of disease |
GB0506133D0 (en) * | 2005-03-24 | 2005-05-04 | Sterix Ltd | Compound |
KR102585191B1 (ko) * | 2020-08-25 | 2023-10-04 | 경기대학교 산학협력단 | 신규한 벤조디아제핀-3-온 유도체 및 이를 포함하는 당뇨병성 신경병증 치료 또는 예방용 약학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3780023A (en) * | 1972-06-30 | 1973-12-18 | J Suh | 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines |
ES484553A1 (es) | 1978-10-05 | 1980-05-16 | Hoechst Ag | Un metodo para preparar 4-fenil-1,3-benzodiazepinas |
US5260339A (en) | 1978-10-05 | 1993-11-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 4-phenyl-1,3-benzodiazepines and 2-amino-α-phenylphenethylamines for treating convulsions and protecting neurons |
FR2540871B1 (fr) * | 1983-02-16 | 1986-01-10 | Lipha | Amino-2 phenyl-5 benzodiazepines-1,3; procede de preparation et medicaments les contenant |
FR2550199B1 (fr) * | 1983-08-02 | 1985-11-29 | Lipha | Imidazo et pyrimido (2,1-b) benzodiazepines-1,3, procedes de preparation et medicament les contenant |
ZA956647B (en) * | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
-
1999
- 1999-07-06 FR FR9908714A patent/FR2796070B1/fr not_active Expired - Fee Related
-
2000
- 2000-07-04 KR KR1020027000137A patent/KR20020022763A/ko not_active Application Discontinuation
- 2000-07-04 CA CA2378165A patent/CA2378165C/en not_active Expired - Fee Related
- 2000-07-04 AU AU59814/00A patent/AU767016B2/en not_active Ceased
- 2000-07-04 EP EP00945864A patent/EP1189890B1/de not_active Expired - Lifetime
- 2000-07-04 SK SK1914-2001A patent/SK19142001A3/sk unknown
- 2000-07-04 PL PL00352333A patent/PL352333A1/xx unknown
- 2000-07-04 HU HU0201785A patent/HUP0201785A3/hu unknown
- 2000-07-04 ES ES00945864T patent/ES2258975T3/es not_active Expired - Lifetime
- 2000-07-04 MX MXPA01013457A patent/MXPA01013457A/es unknown
- 2000-07-04 CZ CZ20014604A patent/CZ20014604A3/cs unknown
- 2000-07-04 RU RU2002102248/04A patent/RU2247115C2/ru not_active IP Right Cessation
- 2000-07-04 BR BR0012169-0A patent/BR0012169A/pt not_active IP Right Cessation
- 2000-07-04 AT AT00945864T patent/ATE323685T1/de not_active IP Right Cessation
- 2000-07-04 JP JP2001507812A patent/JP4699663B2/ja not_active Expired - Fee Related
- 2000-07-04 DE DE60027429T patent/DE60027429T2/de not_active Expired - Lifetime
- 2000-07-04 US US10/019,683 patent/US7323458B1/en not_active Expired - Fee Related
- 2000-07-04 WO PCT/EP2000/006230 patent/WO2001002373A1/fr not_active Application Discontinuation
- 2000-07-04 CN CN00809680A patent/CN1359377A/zh active Pending
- 2000-07-06 AR ARP000103436A patent/AR031071A1/es unknown
-
2002
- 2002-01-04 NO NO20020031A patent/NO20020031L/no not_active Application Discontinuation
- 2002-02-05 ZA ZA200201008A patent/ZA200201008B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1359377A (zh) | 2002-07-17 |
ES2258975T3 (es) | 2006-09-16 |
WO2001002373A8 (fr) | 2001-06-14 |
PL352333A1 (en) | 2003-08-11 |
HUP0201785A3 (en) | 2003-02-28 |
SK19142001A3 (sk) | 2002-06-04 |
CA2378165C (en) | 2010-08-17 |
RU2247115C2 (ru) | 2005-02-27 |
WO2001002373A1 (fr) | 2001-01-11 |
BR0012169A (pt) | 2002-03-19 |
NO20020031L (no) | 2002-03-05 |
ATE323685T1 (de) | 2006-05-15 |
JP2003503483A (ja) | 2003-01-28 |
US7323458B1 (en) | 2008-01-29 |
ZA200201008B (en) | 2003-08-27 |
MXPA01013457A (es) | 2002-07-22 |
NO20020031D0 (no) | 2002-01-04 |
CA2378165A1 (en) | 2001-01-11 |
JP4699663B2 (ja) | 2011-06-15 |
AR031071A1 (es) | 2003-09-10 |
EP1189890A1 (de) | 2002-03-27 |
HUP0201785A2 (hu) | 2002-12-28 |
FR2796070B1 (fr) | 2003-02-21 |
AU5981400A (en) | 2001-01-22 |
AU767016B2 (en) | 2003-10-30 |
DE60027429T2 (de) | 2006-12-14 |
KR20020022763A (ko) | 2002-03-27 |
FR2796070A1 (fr) | 2001-01-12 |
EP1189890B1 (de) | 2006-04-19 |
CZ20014604A3 (cs) | 2002-08-14 |
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