DE60140377D1 - Mch antagonisten und deren verwendung zur behandlung von fettleibigkeit - Google Patents
Mch antagonisten und deren verwendung zur behandlung von fettleibigkeitInfo
- Publication number
- DE60140377D1 DE60140377D1 DE60140377T DE60140377T DE60140377D1 DE 60140377 D1 DE60140377 D1 DE 60140377D1 DE 60140377 T DE60140377 T DE 60140377T DE 60140377 T DE60140377 T DE 60140377T DE 60140377 D1 DE60140377 D1 DE 60140377D1
- Authority
- DE
- Germany
- Prior art keywords
- fatibility
- treatment
- mch antagonists
- mch
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/14—Nitrogen atoms not forming part of a nitro radical
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25050200P | 2000-12-01 | 2000-12-01 | |
PCT/US2001/045242 WO2002057233A1 (en) | 2000-12-01 | 2001-11-29 | Mch antagonists and their use in the treatment of obesity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60140377D1 true DE60140377D1 (de) | 2009-12-17 |
Family
ID=22948006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60140377T Expired - Lifetime DE60140377D1 (de) | 2000-12-01 | 2001-11-29 | Mch antagonisten und deren verwendung zur behandlung von fettleibigkeit |
Country Status (13)
Country | Link |
---|---|
US (1) | US20030022891A1 (de) |
EP (1) | EP1339684B1 (de) |
JP (1) | JP4454933B2 (de) |
CN (1) | CN1478076A (de) |
AR (1) | AR034421A1 (de) |
AT (1) | ATE447552T1 (de) |
CA (1) | CA2429844C (de) |
DE (1) | DE60140377D1 (de) |
ES (1) | ES2334889T3 (de) |
HK (1) | HK1054225A1 (de) |
MX (1) | MXPA03004915A (de) |
PE (1) | PE20020706A1 (de) |
WO (1) | WO2002057233A1 (de) |
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USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
EP1392298B1 (de) | 2001-05-04 | 2009-02-18 | Amgen Inc. | Kondensierte heterozyklische verbindungen |
US6809104B2 (en) | 2001-05-04 | 2004-10-26 | Tularik Inc. | Fused heterocyclic compounds |
WO2003035055A1 (en) * | 2001-10-25 | 2003-05-01 | Schering Corporation | Mch antagonists for the treatment of obesity |
JP2005526709A (ja) | 2002-01-10 | 2005-09-08 | ニューロジェン・コーポレーション | メラニン凝集ホルモン受容体リガンド:置換ベンゾイミダゾールアナログ |
US7160879B2 (en) | 2002-01-10 | 2007-01-09 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1H-benzoimidazole analogues |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
AU2003244455A1 (en) | 2002-02-08 | 2003-09-02 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
MXPA05000200A (es) * | 2002-07-02 | 2005-06-06 | Schering Corp | Nuevos antagonistas del receptor neuropeptido y y5. |
DE10238865A1 (de) * | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US20040077650A1 (en) * | 2002-10-18 | 2004-04-22 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
US7351719B2 (en) * | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
DE10250743A1 (de) * | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
KR20050103184A (ko) | 2002-11-06 | 2005-10-27 | 암젠 인코포레이션 | 융합된 헤테로사이클릭 화합물들 |
WO2004080411A2 (en) * | 2003-03-07 | 2004-09-23 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
WO2005051381A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) |
WO2005051380A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octahydroindols as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
DK1723128T3 (da) * | 2004-01-06 | 2013-02-18 | Novo Nordisk As | Heteroarylurinstoffer og deres anvendelse som glucokinaseaktivatorer |
US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
US7241787B2 (en) | 2004-01-25 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments |
US8372848B2 (en) * | 2004-03-23 | 2013-02-12 | Mixture Sciences, Inc. | Melanin-concentrating hormone receptor antagonists and methods of use |
DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
US7361769B2 (en) * | 2004-07-16 | 2008-04-22 | Schering Corporation | Heterocyclyls as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders |
DE102004039789A1 (de) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CN101076524A (zh) * | 2004-10-12 | 2007-11-21 | 法马科皮亚药物研发公司 | 作为选择性黑色素浓集激素受体拮抗剂的治疗肥胖和相关病症的双环化合物 |
GB0428514D0 (en) * | 2004-12-31 | 2005-02-09 | Prosidion Ltd | Compounds |
WO2006104280A1 (ja) * | 2005-03-31 | 2006-10-05 | Takeda Pharmaceutical Company Limited | 糖尿病の予防・治療剤 |
US20070149600A1 (en) * | 2005-04-25 | 2007-06-28 | Andrew Browning | Substituted octahydroisoindoles |
EP1987006B1 (de) | 2006-02-15 | 2011-01-12 | Sanofi-Aventis | Neue aminoalkohol-substituierte aryldihydroisochinolinone, herstellungsverfahren und ihre verwendung als medikamente |
WO2008008398A2 (en) * | 2006-07-14 | 2008-01-17 | Shionogi & Co., Ltd. | Oxime compounds and the use thereof |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2012113103A1 (en) | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Asymmetric ureas and medical uses thereof |
CN103288684B (zh) * | 2013-05-03 | 2014-12-10 | 西安交通大学 | 一种具有抗肿瘤活性的联苯脲化合物及其制备方法 |
MX2018000418A (es) * | 2015-07-29 | 2018-08-14 | Esteve Labor Dr | Derivados de amida que tienen actividad multimodal contra el dolor. |
RS64027B1 (sr) | 2016-03-22 | 2023-03-31 | Helsinn Healthcare Sa | Benzenesulfonil-asimetrične uree i njihove medicinske upotrebe |
US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US5908830A (en) * | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
EP0955293B1 (de) * | 1996-12-03 | 2003-03-19 | Banyu Pharmaceutical Co., Ltd. | Harnstoffderivate |
EP1086078B1 (de) * | 1998-06-08 | 2003-02-05 | Schering Corporation | Neuropeptid y5-rezeptorantagonisten |
-
2001
- 2001-11-28 US US09/995,949 patent/US20030022891A1/en not_active Abandoned
- 2001-11-29 AR ARP010105563A patent/AR034421A1/es unknown
- 2001-11-29 ES ES01988218T patent/ES2334889T3/es not_active Expired - Lifetime
- 2001-11-29 CN CNA018196810A patent/CN1478076A/zh active Pending
- 2001-11-29 DE DE60140377T patent/DE60140377D1/de not_active Expired - Lifetime
- 2001-11-29 JP JP2002557914A patent/JP4454933B2/ja not_active Expired - Fee Related
- 2001-11-29 MX MXPA03004915A patent/MXPA03004915A/es not_active Application Discontinuation
- 2001-11-29 CA CA002429844A patent/CA2429844C/en not_active Expired - Fee Related
- 2001-11-29 WO PCT/US2001/045242 patent/WO2002057233A1/en active Application Filing
- 2001-11-29 EP EP01988218A patent/EP1339684B1/de not_active Expired - Lifetime
- 2001-11-29 PE PE2001001199A patent/PE20020706A1/es not_active Application Discontinuation
- 2001-11-29 AT AT01988218T patent/ATE447552T1/de not_active IP Right Cessation
-
2003
- 2003-09-09 HK HK03106384.8A patent/HK1054225A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA03004915A (es) | 2003-09-05 |
JP2004517890A (ja) | 2004-06-17 |
ATE447552T1 (de) | 2009-11-15 |
CA2429844C (en) | 2009-10-13 |
CA2429844A1 (en) | 2002-07-25 |
EP1339684B1 (de) | 2009-11-04 |
JP4454933B2 (ja) | 2010-04-21 |
PE20020706A1 (es) | 2002-08-09 |
US20030022891A1 (en) | 2003-01-30 |
AR034421A1 (es) | 2004-02-25 |
ES2334889T3 (es) | 2010-03-17 |
HK1054225A1 (zh) | 2003-11-21 |
WO2002057233A1 (en) | 2002-07-25 |
EP1339684A1 (de) | 2003-09-03 |
CN1478076A (zh) | 2004-02-25 |
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