PE20020706A1 - Antagonistas de mch y su uso en el tratamiento de la obesidad - Google Patents

Antagonistas de mch y su uso en el tratamiento de la obesidad

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Publication number
PE20020706A1
PE20020706A1 PE2001001199A PE2001001199A PE20020706A1 PE 20020706 A1 PE20020706 A1 PE 20020706A1 PE 2001001199 A PE2001001199 A PE 2001001199A PE 2001001199 A PE2001001199 A PE 2001001199A PE 20020706 A1 PE20020706 A1 PE 20020706A1
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PE
Peru
Prior art keywords
alkyl
aryl
cycloalkyl
heteroaryl
obesity
Prior art date
Application number
PE2001001199A
Other languages
English (en)
Inventor
John Clader
Mark D Mcbriar
Ruo Xu
Sherry A Shapiro
Anandan Palani
Original Assignee
Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20020706A1 publication Critical patent/PE20020706A1/es

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    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE Ar1 ES ARILO, HETEROARILO; Ar2 ES ARILO, HETEROARILO, ARALQUILO Ar1 Y Ar2 FORMAN JUNTOS FLUORENO, FLUORENONA; CON LA CONDICION QUE Ar3 SEA ARILENO; Ar3 ES ARILENO, HETEROARILENO; X ES O, S, C-N; Y ES UN ENLACE, ALQUILENO C1-C4; R1 ES TIAZOL, ARILO, HETEROARILO, N(R5)2, NHCO-ALQUILENO C2-C3N(R5)2, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, CICLOALQUILO C3-C7-ALQUILO C1-C6, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, NH-ALQUILO C1-C6, CICLOALQUILO C3-C7, ARILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ARILO, ARALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-{3'-CIANO[1,1'-BIFENIL-4-IL]-N-(1-CICLOPENTIL-4-PIPERIDINIL)-N'-(5-DICLOROFENIL)UREA, N-[3'-CIANO [1,1'-BIFENIL]-4-IL]-N-(1-CICLOPENTIL-4-PIPERIDINIL)-N'-[(3,5-DICLOROFENIL)METIL]UREA, ENTRE OTROS; TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE UN AGENTE ANTIOBESIDAD, ANORECTICO, AGONISTA ß3, AGENTE TIROMIMETICO, ANTAGONISTA NPY, UN INHIBIDOR DE ALDOSA REDUCTASA, UN INHIBIDOR DE GLICOGENO FOSFORILASA, ENTRE OTROS. EL COMPUESTO ES ANTAGONISTA DE LA HORMONA QUE CONCENTRA LA MELANINA (MCH) Y PUEDE SER UTIL PARA EL TRATAMIENTO DE UN TRASTORNO METABOLICO (OBESIDAD), DE ALIMENTACION (HIPERFAGIA), DIABETES
PE2001001199A 2000-12-01 2001-11-29 Antagonistas de mch y su uso en el tratamiento de la obesidad PE20020706A1 (es)

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EP1339684A1 (en) 2003-09-03
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