PE20001539A1 - Composiciones farmaceuticas con agentes tiromimeticos antiobesidad - Google Patents
Composiciones farmaceuticas con agentes tiromimeticos antiobesidadInfo
- Publication number
- PE20001539A1 PE20001539A1 PE2000000162A PE0001622000A PE20001539A1 PE 20001539 A1 PE20001539 A1 PE 20001539A1 PE 2000000162 A PE2000000162 A PE 2000000162A PE 0001622000 A PE0001622000 A PE 0001622000A PE 20001539 A1 PE20001539 A1 PE 20001539A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- trifluoromethyl
- cycloalkyl
- aryl
- hydroxy
- Prior art date
Links
- 230000003579 anti-obesity Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003749 thyromimetic agent Substances 0.000 title 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 abstract 2
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 abstract 1
- -1 CARBOXYL Chemical class 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
- 229960002179 ephedrine Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 abstract 1
- 229960000395 phenylpropanolamine Drugs 0.000 abstract 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 abstract 1
- 229960003908 pseudoephedrine Drugs 0.000 abstract 1
- 230000009103 reabsorption Effects 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 230000000862 serotonergic effect Effects 0.000 abstract 1
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004425 sibutramine Drugs 0.000 abstract 1
- 229940127230 sympathomimetic drug Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Valve Device For Special Equipments (AREA)
- Refinement Of Pig-Iron, Manufacture Of Cast Iron, And Steel Manufacture Other Than In Revolving Furnaces (AREA)
- Discharging, Photosensitive Material Shape In Electrophotography (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION QUE COMPRENDE DERIVADOS DE ACIDOS HETEROACETICOS I; DONDE: R ES OH; R1 Y R2 SON TRIFLUOROMETILO, ALQUILO; R3 ES HALOGENO, TRIFLUOROMETILO, ALQUILO, ALCANOILO, ARILO, HIDROXI-ALQUILO, ARIL-ALQUILO, CICLOALQUILO, ARILMETILO CARBOCICLICO, AROILO CARBOCICLICO, ENTRE OTROS; R3 ES (R8)(R9)(R10)-C-; R8 ES H, ALQUILO, ARILO, CICLOALQUILO, ARILALQUILO, CICLOALQUIL-ALQUILO; R9 ES H, ACILOXI; R10 ES H, ALQUILO; O R9 Y R10 JUNTO CON C FORMAN UN CARBONILO; R4 ES H, HALOGENO, TRIFLUOROMETILO, ALQUILO; R5 Y R6 SON H, ALQUILO O JUNTO A C FORMAN UN CARBONILO; X ES O, S, NR7; R7 ES H, ALQUILO; W ES O, S; Z ES CARBOXILO DERIVATIZADO. SON COMPUESTOS PREFERIDOS ACIDO N-[3,5-DIMETIL-4-(4`-HIDROXI-3'-ISOPROPILFENOXI)FENIL]OXAMICO, ACIDO N-[3,5-DICLORO-4-(4'-HIDROXI-3'-ISOPROPILFENOXI)FENIL]OXAMICO, ENTRE OTROS. TAMBIEN SE REFIERE AL USO CON UN ANORETICO TAL COMO FENILPROPANOLAMINA, EFEDRINA, PSEUDOEFEDRINA, FENTERMINA, UN ANTAGONISTA DEL NPY, UN AGONISTA DE CCK-A; UN INHIBIDOR DE REABSORCION DE MONOAMINAS (SIBUTRAMINA), UN AGENTE SIMPATICOMIMETICO, UN AGENTE SEROTONERGICO (DEXFENFLURAMINA, FENFLURAMINA), UN AGONISTA DE DOPAMINA, LEPTINA, ANTAGONISTA DE LA GALANINA, UN ANTAGONISTA DEL RECEPTOR CANNABINOIDE, ENTRE OTROS; EL COMPUESTO I TIENE PROPIEDADES TERMOGENAS Y PUEDE SER UTIL PARA EL TRATAMIENTO DE OBESIDAD
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12201599P | 1999-03-01 | 1999-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001539A1 true PE20001539A1 (es) | 2001-01-08 |
Family
ID=22400061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000162A PE20001539A1 (es) | 1999-03-01 | 2000-02-28 | Composiciones farmaceuticas con agentes tiromimeticos antiobesidad |
Country Status (15)
Country | Link |
---|---|
US (2) | US6344481B1 (es) |
EP (1) | EP1036564B1 (es) |
JP (1) | JP2000256190A (es) |
KR (1) | KR100368354B1 (es) |
AT (1) | ATE282410T1 (es) |
AU (1) | AU1635300A (es) |
CA (1) | CA2299972C (es) |
CO (1) | CO5150235A1 (es) |
DE (1) | DE60015831T2 (es) |
ES (1) | ES2233282T3 (es) |
HU (1) | HUP0000921A3 (es) |
IL (1) | IL134382A0 (es) |
NZ (1) | NZ503122A (es) |
PE (1) | PE20001539A1 (es) |
ZA (1) | ZA200001000B (es) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
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US6716810B1 (en) * | 1998-12-09 | 2004-04-06 | Eleanor Roosevelt Institute | Composition and method for regulation of body weight and associated conditions |
US6344481B1 (en) * | 1999-03-01 | 2002-02-05 | Pfizer Inc. | Thyromimetic antiobesity agents |
WO2002081751A2 (en) * | 2001-04-03 | 2002-10-17 | The Regents Of The University Of California | A method of increasing endogenous leptin production |
US20070203225A1 (en) * | 2001-04-03 | 2007-08-30 | Havel Peter J | Method of increasing endogenous adiponectin production and leptin production |
NZ534757A (en) * | 2002-03-12 | 2006-07-28 | Merck & Co Inc | Substituted amides |
US6825209B2 (en) | 2002-04-15 | 2004-11-30 | Research Triangle Institute | Compounds having unique CB1 receptor binding selectivity and methods for their production and use |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
EP1556373A1 (en) * | 2002-10-18 | 2005-07-27 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
US20040122033A1 (en) * | 2002-12-10 | 2004-06-24 | Nargund Ravi P. | Combination therapy for the treatment of obesity |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
CA2551037A1 (en) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
US7829552B2 (en) * | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
EP1730310A2 (en) * | 2004-03-22 | 2006-12-13 | The Regents Of The University Of California | A formulation for increasing endogenous adiponectin and leptin production |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
US20090028925A1 (en) * | 2005-05-26 | 2009-01-29 | Erion Mark D | Novel Phosphinic Acid-Containing Thyromimetics |
MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
RU2417985C2 (ru) | 2005-05-30 | 2011-05-10 | Баниу Фармасьютикал Ко., Лтд. | Новые производные пиперидина |
US20100216758A1 (en) | 2005-08-10 | 2010-08-26 | Makoto Ando | Pyridone Compounds |
JPWO2007024004A1 (ja) | 2005-08-24 | 2009-03-05 | 萬有製薬株式会社 | フェニルピリドン誘導体 |
EP1939194A4 (en) | 2005-09-07 | 2010-12-08 | Banyu Pharma Co Ltd | AROMATIC SUBSTITUTED BICYLIC PYRIDONE DERIVATIVE |
EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
JP2009512715A (ja) | 2005-10-21 | 2009-03-26 | ノバルティス アクチエンゲゼルシャフト | レニン阻害剤と抗異脂肪血症剤および/または抗肥満症剤の組み合わせ |
CA2627139A1 (en) | 2005-10-27 | 2007-05-03 | Banyu Pharmaceutical Co., Ltd. | Novel benzoxathiin derivative |
EP1953165B1 (en) | 2005-11-10 | 2012-02-01 | Msd K.K. | Aza-substituted spiro derivative |
WO2007132475A1 (en) * | 2006-05-15 | 2007-11-22 | Cadila Healthcare Limited | Selective tr-beta 1 agonist |
EP2083831B1 (en) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
CA2664358A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diarylketimine derivative |
EP2145884B1 (en) | 2007-04-02 | 2014-08-06 | Msd K.K. | Indoledione derivative |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2009110510A1 (ja) | 2008-03-06 | 2009-09-11 | 萬有製薬株式会社 | アルキルアミノピリジン誘導体 |
JPWO2009119726A1 (ja) | 2008-03-28 | 2011-07-28 | Msd株式会社 | メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体 |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JPWO2010013595A1 (ja) | 2008-07-30 | 2012-01-12 | Msd株式会社 | 5員−5員又は5員−6員縮環シクロアルキルアミン誘導体 |
CN102264228A (zh) | 2008-10-22 | 2011-11-30 | 默沙东公司 | 用于抗糖尿病药的新的环状苯并咪唑衍生物 |
WO2010049946A2 (en) | 2008-10-27 | 2010-05-06 | Cadila Healthcare Limited | Thyroid receptor ligands |
US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
WO2010086878A2 (en) | 2009-01-09 | 2010-08-05 | Cadila Healthcare Limited | Thyroid receptor modulators |
CN102459185B (zh) | 2009-04-20 | 2015-06-03 | 田边三菱制药株式会社 | 新型甲状腺激素β受体激动剂 |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US9401828B2 (en) | 2010-05-20 | 2016-07-26 | Kandou Labs, S.A. | Methods and systems for low-power and pin-efficient communications with superposition signaling codes |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
WO2012118972A2 (en) | 2011-03-01 | 2012-09-07 | Synegy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
BR112015019836A2 (pt) | 2013-02-22 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
EP3186242B1 (en) | 2014-08-29 | 2021-10-06 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
EP3526199B1 (en) | 2016-10-14 | 2022-04-13 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
KR20190104524A (ko) | 2016-11-21 | 2019-09-10 | 바이킹 테라퓨틱스 인코포레이티드 | 당원축적질환의 치료 방법 |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
WO2018226604A1 (en) | 2017-06-05 | 2018-12-13 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis |
JP7360583B2 (ja) | 2017-09-14 | 2023-10-13 | 国立研究開発法人理化学研究所 | 網膜組織の製造方法 |
EP3768690A4 (en) | 2018-03-22 | 2021-11-24 | Viking Therapeutics, Inc. | CRYSTALLINE SHAPES AND METHOD FOR MAKING CRYSTALLINE SHAPES OF A COMPOUND |
CN113302189A (zh) | 2018-11-20 | 2021-08-24 | Tes制药有限责任公司 | α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂 |
KR20210138639A (ko) | 2019-03-13 | 2021-11-19 | 다이니뽄 스미토모 세이야쿠 가부시키가이샤 | 이식용 신경 망막의 품질을 평가하는 방법 및 이식용 신경 망막 시트 |
JPWO2022054924A1 (es) | 2020-09-11 | 2022-03-17 | ||
EP4206321A4 (en) | 2020-09-11 | 2024-05-01 | Riken | COMPLEX CONTAINING CELLULAR AGGREGATES CONTAINING NEURAL RETINA, MATRIX AND METHOD OF MANUFACTURING |
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-
2000
- 2000-01-20 US US09/488,110 patent/US6344481B1/en not_active Expired - Fee Related
- 2000-02-03 AT AT00300830T patent/ATE282410T1/de not_active IP Right Cessation
- 2000-02-03 IL IL13438200A patent/IL134382A0/xx unknown
- 2000-02-03 EP EP00300830A patent/EP1036564B1/en not_active Expired - Lifetime
- 2000-02-03 ES ES00300830T patent/ES2233282T3/es not_active Expired - Lifetime
- 2000-02-03 DE DE60015831T patent/DE60015831T2/de not_active Expired - Fee Related
- 2000-02-11 AU AU16353/00A patent/AU1635300A/en not_active Abandoned
- 2000-02-25 JP JP2000049507A patent/JP2000256190A/ja active Pending
- 2000-02-28 PE PE2000000162A patent/PE20001539A1/es not_active Application Discontinuation
- 2000-02-28 HU HU0000921A patent/HUP0000921A3/hu unknown
- 2000-02-28 KR KR10-2000-0009860A patent/KR100368354B1/ko not_active IP Right Cessation
- 2000-02-29 CA CA002299972A patent/CA2299972C/en not_active Expired - Fee Related
- 2000-02-29 NZ NZ503122A patent/NZ503122A/en unknown
- 2000-02-29 ZA ZA200001000A patent/ZA200001000B/xx unknown
- 2000-03-01 CO CO00014834A patent/CO5150235A1/es unknown
-
2001
- 2001-10-16 US US09/978,980 patent/US6555578B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HUP0000921A2 (hu) | 2000-12-28 |
NZ503122A (en) | 2001-11-30 |
ZA200001000B (en) | 2001-08-29 |
IL134382A0 (en) | 2001-04-30 |
US6555578B2 (en) | 2003-04-29 |
EP1036564A1 (en) | 2000-09-20 |
US6344481B1 (en) | 2002-02-05 |
HUP0000921A3 (en) | 2004-06-28 |
EP1036564B1 (en) | 2004-11-17 |
DE60015831T2 (de) | 2005-12-15 |
DE60015831D1 (de) | 2004-12-23 |
HU0000921D0 (en) | 2000-04-28 |
CA2299972C (en) | 2003-08-19 |
AU1635300A (en) | 2000-09-07 |
KR100368354B1 (ko) | 2003-01-24 |
KR20010006712A (ko) | 2001-01-26 |
ES2233282T3 (es) | 2005-06-16 |
CO5150235A1 (es) | 2002-04-29 |
CA2299972A1 (en) | 2000-09-01 |
ATE282410T1 (de) | 2004-12-15 |
US20020035153A1 (en) | 2002-03-21 |
JP2000256190A (ja) | 2000-09-19 |
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