DK0775129T3 - 3-Benzoylbenzofuranderivater som thyroidhormonantagonister - Google Patents

3-Benzoylbenzofuranderivater som thyroidhormonantagonister

Info

Publication number
DK0775129T3
DK0775129T3 DK95929866T DK95929866T DK0775129T3 DK 0775129 T3 DK0775129 T3 DK 0775129T3 DK 95929866 T DK95929866 T DK 95929866T DK 95929866 T DK95929866 T DK 95929866T DK 0775129 T3 DK0775129 T3 DK 0775129T3
Authority
DK
Denmark
Prior art keywords
pct
thyroid hormone
hormone antagonists
sec
alkyl
Prior art date
Application number
DK95929866T
Other languages
English (en)
Inventor
Charlotta Mellin
Original Assignee
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab filed Critical Karobio Ab
Application granted granted Critical
Publication of DK0775129T3 publication Critical patent/DK0775129T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK95929866T 1994-08-11 1995-08-11 3-Benzoylbenzofuranderivater som thyroidhormonantagonister DK0775129T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9416219A GB9416219D0 (en) 1994-08-11 1994-08-11 Receptor ligands
PCT/EP1995/003214 WO1996005190A1 (en) 1994-08-11 1995-08-11 3-benzoyl benzofuran derivatives as thyroid hormone antagonists

Publications (1)

Publication Number Publication Date
DK0775129T3 true DK0775129T3 (da) 1999-06-28

Family

ID=10759723

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95929866T DK0775129T3 (da) 1994-08-11 1995-08-11 3-Benzoylbenzofuranderivater som thyroidhormonantagonister

Country Status (12)

Country Link
US (1) US5854282A (da)
EP (1) EP0775129B1 (da)
JP (1) JPH10504297A (da)
KR (1) KR970704725A (da)
AT (1) ATE172460T1 (da)
AU (1) AU694551B2 (da)
CA (1) CA2197185A1 (da)
DE (1) DE69505542T2 (da)
DK (1) DK0775129T3 (da)
ES (1) ES2123287T3 (da)
GB (1) GB9416219D0 (da)
WO (1) WO1996005190A1 (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3791799A (en) * 1998-05-12 1999-11-29 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6317722B1 (en) * 1998-09-18 2001-11-13 Amazon.Com, Inc. Use of electronic shopping carts to generate personal recommendations
FR2803846B1 (fr) * 2000-01-17 2002-04-05 Clariant France Sa 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation
GB0015205D0 (en) 2000-06-21 2000-08-09 Karobio Ab Bioisosteric thyroid receptor ligands and method
FR2817864B1 (fr) * 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
US20050065208A1 (en) * 2001-07-20 2005-03-24 Bodo Brandts Benzofuranes and their use in the treatment of atrial fibrillation
DE10237819A1 (de) * 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
AU2004293013B2 (en) * 2003-11-19 2011-04-28 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
FR2864536B1 (fr) * 2003-12-24 2006-03-17 Clariant France Sa Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
CA2606499C (en) 2005-05-26 2017-06-13 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
RU2007148927A (ru) * 2005-05-26 2009-07-10 Метабэйзис Терапьютикс, Инк. (Us) Новые тиреомиметики, содержащие фосфиновую кислоту
GB0611210D0 (en) * 2006-06-07 2006-07-19 Cambrex Karlskoga Ab Process
CA2655913A1 (en) * 2006-06-28 2008-01-03 Sanwa Kagaku Kenkyusho Co., Ltd. Novel 6-5 system bicyclic heterocyclic derivative and its pharmaceutical utility
KR100858357B1 (ko) * 2006-10-02 2008-09-11 (주) 디지탈바이오텍 벤조퓨란계 유도체 화합물을 유효성분으로 함유하는인지기능 장애의 예방 및 치료용 조성물
FR2914643B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation du 2-(n-butyl)-5-nitrobenzofurane
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
FR2915482B1 (fr) * 2007-04-27 2009-11-27 Finorga Procede de preparation du 2-(n-butyl)-5-nitrobenzofurane.
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
CN101948455B (zh) * 2010-10-18 2012-11-14 山东邹平大展新材料有限公司 一种2-正丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃的制备方法
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
KR20190104524A (ko) 2016-11-21 2019-09-10 바이킹 테라퓨틱스 인코포레이티드 당원축적질환의 치료 방법
BR112019025659A2 (pt) 2017-06-05 2020-08-25 Viking Therapeutics, Inc. composições para o tratamento de fibrose
JP2021518403A (ja) 2018-03-22 2021-08-02 バイキング・セラピューティクス・インコーポレイテッド 化合物の結晶形態及び化合物の結晶形態を生成する方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255585A (en) * 1975-10-22 1981-03-10 Centre European De Recherches Pharmacologique Benzoheterocyclic derivatives of phenoxyacetic acid
DE3342624A1 (de) * 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzaronderivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
JP2873599B2 (ja) * 1990-03-09 1999-03-24 寿製薬株式会社 新規ベンゾフラン誘導体、尿酸排泄剤及びその製法
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
SE9101509D0 (sv) * 1991-05-17 1991-05-17 Karobio Ab Receptor ligands

Also Published As

Publication number Publication date
EP0775129B1 (en) 1998-10-21
JPH10504297A (ja) 1998-04-28
AU694551B2 (en) 1998-07-23
KR970704725A (ko) 1997-09-06
WO1996005190A1 (en) 1996-02-22
US5854282A (en) 1998-12-29
ATE172460T1 (de) 1998-11-15
DE69505542D1 (de) 1998-11-26
AU3345595A (en) 1996-03-07
GB9416219D0 (en) 1994-10-05
ES2123287T3 (es) 1999-01-01
EP0775129A1 (en) 1997-05-28
CA2197185A1 (en) 1996-02-22
DE69505542T2 (de) 1999-06-02

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