AU3791799A - Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia - Google Patents

Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Info

Publication number
AU3791799A
AU3791799A AU37917/99A AU3791799A AU3791799A AU 3791799 A AU3791799 A AU 3791799A AU 37917/99 A AU37917/99 A AU 37917/99A AU 3791799 A AU3791799 A AU 3791799A AU 3791799 A AU3791799 A AU 3791799A
Authority
AU
Australia
Prior art keywords
hyperglycemia
treatment
insulin resistance
acetic acids
acids useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37917/99A
Inventor
Arlene Joan Dietrich
Iwan Gunawan
Zenan Li
Michael Sotirios Malamas
Jay Edward Wrobel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of AU3791799A publication Critical patent/AU3791799A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU37917/99A 1998-05-12 1999-05-10 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia Abandoned AU3791799A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7659698A 1998-05-12 1998-05-12
US09076596 1998-05-12
PCT/US1999/010211 WO1999058519A1 (en) 1998-05-12 1999-05-10 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Publications (1)

Publication Number Publication Date
AU3791799A true AU3791799A (en) 1999-11-29

Family

ID=22133037

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37917/99A Abandoned AU3791799A (en) 1998-05-12 1999-05-10 Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Country Status (6)

Country Link
EP (1) EP1077965A1 (en)
JP (1) JP2002514636A (en)
CN (1) CN1308621A (en)
AU (1) AU3791799A (en)
CA (1) CA2331120A1 (en)
WO (1) WO1999058519A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498182B2 (en) 2000-09-26 2002-12-24 Biovitrum Ab Compounds
CA2437118A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
TWI224101B (en) 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7291639B2 (en) 2001-06-20 2007-11-06 Wyeth Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
DK1397130T3 (en) 2001-06-20 2007-11-12 Wyeth Corp Substituted Indole Acid Derivatives as Inhibitors of Plasminogen Activator Inhibitor-1 (PAI-1)
US20050065208A1 (en) * 2001-07-20 2005-03-24 Bodo Brandts Benzofuranes and their use in the treatment of atrial fibrillation
US6784205B2 (en) * 2002-03-01 2004-08-31 Sunesis Pharmaceuticals, Inc. Compounds that modulate the activity of PTP-1B and TC-PTP
BR0316584A (en) 2002-12-10 2005-10-04 Wyeth Corp Substituted oxo-acetyl amino indole acetic acid derivatives as plasminogen activator inhibitor-1 inhibitors (parent-1)
DE60306548T2 (en) 2002-12-10 2007-06-21 Wyeth SUBSTITUTED 3-CARBONYL-1-YL-ACETIC DERIVATIVES AS PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) INHIBITORS
UA80453C2 (en) 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
JP2006510673A (en) 2002-12-10 2006-03-30 ワイス Aryl, aryloxy and alkyloxy substituted 1H-indol-3-ylglyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor 1 (PAI-1)
US7348351B2 (en) 2002-12-10 2008-03-25 Wyeth Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
US7141592B2 (en) 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7163954B2 (en) 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7446201B2 (en) 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7582773B2 (en) 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7265148B2 (en) 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7411083B2 (en) 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7268159B2 (en) 2003-09-25 2007-09-11 Wyeth Substituted indoles
US7351726B2 (en) 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7332521B2 (en) 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7342039B2 (en) 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7141596B2 (en) 2003-10-08 2006-11-28 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
FR2862646B1 (en) 2003-11-20 2006-02-24 Merck Sante Sas NOVEL ANTIDIABETIC COMPOUNDS CONTAINING BENZOFURAN, BENZOTHIOPHENIC DERIVATIVES
FR2862645B1 (en) * 2003-11-20 2007-06-22 Merck Sante Sas ANTIDIABETIC COMPOUNDS CONTAINING BENZOFURAN, BENZOTHIOPHENIC DERIVATIVES
FR2864536B1 (en) * 2003-12-24 2006-03-17 Clariant France Sa PROCESS FOR THE PREPARATION OF N-ALKYL-2 (HYDROXY-4-BENZOYL) -3 BENZOFURANES AND INTERMEDIATES FOR CARRYING OUT SAID METHOD
WO2006023865A1 (en) 2004-08-23 2006-03-02 Wyeth Oxazolo-naphthyl acids as plaminogen activator inhibtor type-1 (pai-1) modulators useful in the treatment of thrombosis and cardiovascular diseases
AU2006279496A1 (en) 2005-08-17 2007-02-22 Wyeth Substituted indoles and use thereof
WO2012048058A2 (en) * 2010-10-06 2012-04-12 J-Pharma Co., Ltd. Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
CN102718735B (en) * 2012-05-28 2014-04-23 沈阳药科大学 2-ethyl-3-(4-hydroxy) benzoyl benzofuran compounds and compositions and preparation methods of compounds
EP3360870A1 (en) 2013-02-19 2018-08-15 Novartis AG Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
CN108084186B (en) * 2016-11-16 2021-06-25 江苏新元素医药科技有限公司 URAT1 inhibitor and application thereof
WO2023149549A1 (en) * 2022-02-03 2023-08-10 国立大学法人富山大学 Novel pharmaceutical composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3012042A (en) * 1956-12-21 1961-12-05 Belge Produits Chimiques Sa Benzofurans
DE3342624A1 (en) * 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzarone derivatives, process for their preparation and medicaments containing these derivatives
FR2653431B1 (en) * 1989-10-23 1994-05-27 Sanofi Sa PROCESS FOR THE PREPARATION OF BENZOYL-3 BENZOFURAN DERIVATIVES.
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
SE9101509D0 (en) * 1991-05-17 1991-05-17 Karobio Ab RECEPTOR LIGANDS
DE4239429A1 (en) * 1992-11-24 1994-05-26 Merck Patent Gmbh Process for the preparation of immunoconjugates
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
AU2381397A (en) * 1996-04-19 1997-11-12 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
DE19624292A1 (en) * 1996-06-18 1998-01-02 Merckle Gmbh Preparation of optically pure 1'-hydroxy-benz-bromoarone

Also Published As

Publication number Publication date
EP1077965A1 (en) 2001-02-28
CA2331120A1 (en) 1999-11-18
CN1308621A (en) 2001-08-15
WO1999058519A1 (en) 1999-11-18
JP2002514636A (en) 2002-05-21

Similar Documents

Publication Publication Date Title
AU3791799A (en) Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
AU4072799A (en) 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
AU6212099A (en) Improvements in or relating to hypodermic syringes
HK1045111B (en) (3-trihalomethylphenoxy) (4-halophenyl) for the treatment of insulin resistance and type 2 diabetes
AUPM348594A0 (en) Improvements in syringe pumps
EP1076090A3 (en) ESTs and encoded human proteins
EP1076090A2 (en) ESTs and encoded human proteins
AU6400499A (en) Disposable handle and needle assembly
AU7252798A (en) Processor with sleep and deep sleep modes
AU2543795A (en) Methods of in vivo gene delivery
PL344002A1 (en) Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
AU2961295A (en) Mixing and delivery syringe assembly
IL141403A0 (en) Deleted adenoviruses and methods of making and administering the same
AU1450900A (en) Methods of treatment of type 2 diabetes
AU3823099A (en) Foodstuff with skin containing protein and hydrocolloid
AU4741396A (en) Combined heater and pump
AU4289100A (en) Dihydropyrimidines and their use in the treatment of hepatitis
EG21712A (en) Treatment of insulin resistance
AU2746599A (en) Medical material and medical supply
AU3116599A (en) Di-behenyl fumarate and its use in dermatological products
AU2837301A (en) Use of polymeric material in the treatment of hard surfaces
PL343123A1 (en) Treatment of diabetes with rosiglitazone and insulin
AU4073299A (en) Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
AUPM678294A0 (en) Use of insulin-like growth factor in combination with insulin
AU1476901A (en) Methods for regulating blood glucose and appetite suppression in type 2 diabetics

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase