KR910015558A - 개선된 류코트라이인 길항물질 - Google Patents

개선된 류코트라이인 길항물질 Download PDF

Info

Publication number
KR910015558A
KR910015558A KR1019910002539A KR910002539A KR910015558A KR 910015558 A KR910015558 A KR 910015558A KR 1019910002539 A KR1019910002539 A KR 1019910002539A KR 910002539 A KR910002539 A KR 910002539A KR 910015558 A KR910015558 A KR 910015558A
Authority
KR
South Korea
Prior art keywords
leukotriine
antagonist
improved
hydroxy
phenyl
Prior art date
Application number
KR1019910002539A
Other languages
English (en)
Inventor
마크 가핀스키 다렐
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR910015558A publication Critical patent/KR910015558A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

내용 없음

Description

개선된 류코트라이인 길항물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식 Ⅰ 의 화합물 또는 약학적으로 허용될 수 있는 그의 염기 부가염
    여기에서, Y는 -CO-, -C(=NOH)-, -CHOH-, -CH2-, 혹은 -C(=CH2)- 이고; A는 결합 혹은 -O-이며; R1과 R2중 하나는 수소이고 다른 하나는 -CH2CH2COOH이고, p는 1 내지 16이며, Z는 -H혹은 -G-Q이고 여기서 G는 결합, -O-, -S(O)t-, -NH-, -CH=CH- 혹은 -C≡C- 이고 Q는 페닐 혹은 할로, C1-C3알킬, C1-C3알콕시, 아세틸, 니트로, 아미노, 트리플루오로메틸, 하이드록시 및 -S(O)t-(C1-C3알킬) (여기서 t는 각각 독립적으로 0 내지 2이다)로 구성된 군으로부터 선택된 하나 또는 두 치환체로 치환된 페닐이다.
  2. 튜코트라이인의 과다 방출을 특징으로 하는 어떤 질병에 걸렸거나 걸리기 쉬운 동물을 치료하는데 사용하기 위한 제1항에 청구한 일반식 Ⅰ 의 화합물 또는 약학적으로 허용될 수 있는 그의 염기 부가염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910002539A 1990-02-16 1991-02-13 개선된 류코트라이인 길항물질 KR910015558A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/481,413 US4996230A (en) 1990-02-16 1990-02-16 Leukotriene antagonists
US07/481,413 1990-02-16

Publications (1)

Publication Number Publication Date
KR910015558A true KR910015558A (ko) 1991-09-30

Family

ID=23911845

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910002539A KR910015558A (ko) 1990-02-16 1991-02-13 개선된 류코트라이인 길항물질

Country Status (20)

Country Link
US (1) US4996230A (ko)
EP (1) EP0442748B1 (ko)
JP (1) JPH04211037A (ko)
KR (1) KR910015558A (ko)
CN (1) CN1028639C (ko)
AR (1) AR247205A1 (ko)
AT (1) ATE116980T1 (ko)
AU (1) AU631482B2 (ko)
CA (1) CA2036523A1 (ko)
DE (1) DE69106545T2 (ko)
FI (1) FI910728A (ko)
HU (1) HU208431B (ko)
IE (1) IE910531A1 (ko)
IL (1) IL97242A0 (ko)
NO (1) NO177097C (ko)
NZ (1) NZ237124A (ko)
PT (1) PT96760A (ko)
RU (1) RU2007401C1 (ko)
YU (1) YU27691A (ko)
ZA (1) ZA911111B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30449A (en) * 1991-11-25 1997-05-28 Lilly Co Eli Substituted phenyl phenol leukotriene antagonists
US5352690A (en) * 1992-07-01 1994-10-04 Eli Lilly And Company 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
CA2142735A1 (en) * 1993-06-18 1995-01-05 Tatsuyoshi Tanaka Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent
EP0785930A1 (en) * 1994-10-13 1997-07-30 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b 4? (ltb 4?) antagonists
US5939452A (en) * 1994-10-13 1999-08-17 Pfizer Inc Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists
US5977077A (en) * 1995-08-28 1999-11-02 Interlab Corporation Xanthone analogs for the treatment of infectious diseases
EP0795554A3 (en) * 1996-03-05 1998-01-28 Takeda Chemical Industries, Ltd. (Oxo-)xanthene derivatives, their preparation and their use as immunomodulators
US6613797B2 (en) 1999-12-02 2003-09-02 Interlab, Inc. Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
CN112285355B (zh) * 2020-10-20 2023-01-13 四川大学华西医院 Viridiflorin检测试剂在制备COPD诊断试剂盒中的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7008627A (ko) * 1969-06-25 1970-12-29
US3987088A (en) * 1971-09-08 1976-10-19 Burroughs Wellcome Co. Cyclic carbonyl compounds
FR2278331A1 (fr) * 1974-01-24 1976-02-13 Roussel Uclaf Nouveaux acides carboxyliques et leurs derives, leur application comme medicaments et leur procede de preparation
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
GB1543964A (en) * 1976-04-08 1979-04-11 Ici Ltd Method of antagonising herbicides on soyabean and cotton
EP0093381B1 (en) * 1982-04-27 1986-07-23 The Wellcome Foundation Limited Tricyclic compounds, preparation, use and intermediates
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4661607A (en) * 1984-09-21 1987-04-28 Chugai Seiyaku Kabushiki Kaisha Furoxanthone derivatives useful as diuretics
DE3789299T2 (de) * 1986-12-23 1994-08-04 Warner Lambert Co Verbindungen mit antitumoralen und antibakteriellen Eigenschaften.
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US5242121A (en) * 1991-08-23 1993-09-07 Roto-Mix Enterprises, Ltd. Bale support and cutter

Also Published As

Publication number Publication date
DE69106545D1 (de) 1995-02-23
AU631482B2 (en) 1992-11-26
IL97242A0 (en) 1992-05-25
HU208431B (en) 1993-10-28
CA2036523A1 (en) 1991-08-17
RU2007401C1 (ru) 1994-02-15
FI910728A (fi) 1991-08-17
NO177097C (no) 1995-07-19
NZ237124A (en) 1992-04-28
FI910728A0 (fi) 1991-02-14
YU27691A (sh) 1994-04-05
ZA911111B (en) 1992-10-28
PT96760A (pt) 1991-11-29
NO910608D0 (no) 1991-02-15
AU7110391A (en) 1991-08-22
IE910531A1 (en) 1991-08-28
NO910608L (no) 1991-08-19
AR247205A1 (es) 1994-11-30
EP0442748B1 (en) 1995-01-11
JPH04211037A (ja) 1992-08-03
NO177097B (no) 1995-04-10
HUT56359A (en) 1991-08-28
CN1028639C (zh) 1995-05-31
US4996230A (en) 1991-02-26
EP0442748A1 (en) 1991-08-21
ATE116980T1 (de) 1995-01-15
DE69106545T2 (de) 1995-06-01
CN1054066A (zh) 1991-08-28

Similar Documents

Publication Publication Date Title
KR910015558A (ko) 개선된 류코트라이인 길항물질
KR850003402A (ko) 2-아미노-5-하이드록시-4-메틸 피리미딘 유도체의 제조방법
ES457745A1 (es) Procedimiento para la preparacion de nuevas fluoracil-resor-cinas sustituidas.
BE1003230A3 (fr) Nouveaux derives du benzotriazole, leur preparation et leur utilisation comme absorbants u.v.
SE8503466D0 (sv) Aminofenolforeningar
IE43662L (en) 3-alkoxy-benzo-1,2,4-triazines
KR920703056A (ko) 항 바이러스제
KR920007995A (ko) 벤즈아미드 유도체
KR920702685A (ko) 4,6-o- 히드록시포스포릴글루코사민 유도체
KR860008983A (ko) 4- 벤조일-1- 알킬(알켄일) 피라졸의 제조방법
EP0103895A3 (en) Novel hydroxylamine derivatives, production and use thereof
KR850002255A (ko) 치환 이미다졸리닐 벤조산, 에스테르 및 염의 제조방법
KR920012088A (ko) 신규의 벤즈옥사진 유도체
KR830006285A (ko) 벤조퀴놀리진의 제조방법
KR830001899A (ko) 4-아미노-3-퀴놀린카복실산 및 에스테르-항분비, 항궤양 화합물
KR900012884A (ko) (+)1-[(3,4,5-트리메톡시)-벤질옥시메틸]-1-페닐-N,N-디메틸-n-프로필아민, 그의 제조방법 및 치료학적 용도
KR900016184A (ko) 1, 3-디옥산 유도체
FR2361364A1 (fr) Nouveaux derives d'azetidine
KR930700433A (ko) 신규 디술피드 화합물
KR830008492A (ko) 제초용 조성물
KR900018040A (ko) 생리활성을 갖는 신규의 피라졸 설포네이트 유도체
KR900003162A (ko) 비스(메틸렌디옥시)비페닐 화합물
KR910005865A (ko) 혈압강하제
KR890002179A (ko) 세펨 유도체
KR940014340A (ko) 3-아자비시클로[3.l.0]헥산-2-온 유도체와 제초제 활성 성분으로 이를 포함하는 제조체 조성물

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid